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Protein aggregation: An overview
In order for an ordered protein to perform its specific function, it must have a specific molecular structure. Information about this structure is encoded in the protein's amino acid sequence. The unique functional state is achieved as a result of a specific process, known as protein folding. However, as a result of partial or complete unfolding of theBahareh, Dabirmanesh +2 more
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Protein Denaturation and Aggregation
Annals of the New York Academy of Sciences, 2006Abstract: Protein aggregation is a prominent feature of many neurodegenerative diseases, such as Alzheimer's, Huntington's, and Parkinson's diseases, as well as spongiform encephalopathies and systemic amyloidoses. These diseases are sometimes called protein misfolding diseases, but the latter term begs the question of what is the “folded” state of ...
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Prediction of protein aggregation
The scientific community is very interested in protein aggregation because of its involvement in several neurodegenerative diseases and its significance in industry. Remarkably, fibrillar aggregates are utilized naturally for constructing structural scaffolds or creating biological switches and may be intentionally designed to construct versatile ...Kavyan, Khalili +3 more
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2020
The study of protein aggregates has a long history. While in the first decades until the 80ies of the 20th century only the observation of the presence of such aggregates was reported, later the biochemistry of the formation and the biological effects of theses aggregates were described.
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The study of protein aggregates has a long history. While in the first decades until the 80ies of the 20th century only the observation of the presence of such aggregates was reported, later the biochemistry of the formation and the biological effects of theses aggregates were described.
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Mechanisms and pathology of protein misfolding and aggregation
Nature Reviews Molecular Cell Biology, 2023Nikolaos N Louros +2 more
exaly
In Vitro Cellular & Developmental Biology - Animal, 1996
J, Prachar, K, Hlubinova, A, Feldsamova
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J, Prachar, K, Hlubinova, A, Feldsamova
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Cellular strategies for controlling protein aggregation
Nature Reviews Molecular Cell Biology, 2010Axel Mogk, Bernd Bukau
exaly