AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides
BMC Bioinformatics, 2007 Background Protein aggregation correlates with the development of several debilitating human disorders of growing incidence, such as Alzheimer's and Parkinson's diseases.
Vendrell Josep +5 more
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Protein accumulation in the endoplasmic reticulum as a non-equilibrium phase transition [PDF]
, 2014 Several neurological disorders are associated with the aggregation of aberrant proteins, often localized in intracellular organelles such as the endoplasmic reticulum.
Budrikis, Z. +3 more
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The regions of the sequence most exposed to the solvent within the amyloidogenic state of a protein initiate the aggregation process. [PDF]
, 2004 Formation of misfolded aggregates is an essential part of what proteins can do. The process of protein aggregation is central to many human diseases and any aggregating event needs to be prevented within a cell and in protein design.
AMORESANO, ANGELA +6 more
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Cholesterol impairment contributes to neuroserpin aggregation [PDF]
, 2017 Intraneural accumulation of misfolded proteins is a common feature of several neurodegenerative pathologies including Alzheimer's and Parkinson's diseases, and Familial Encephalopathy with Neuroserpin Inclusion Bodies (FENIB). FENIB is a rare disease due
Costantini, Giulio +5 more
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Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases. [PDF]
, 2019 The gold standard for a definitive diagnosis of Parkinson disease (PD) is the pathologic finding of aggregated α-synuclein into Lewy bodies and for Alzheimer disease (AD) aggregated amyloid into plaques and hyperphosphorylated tau into tangles.
Brundin, P +26 more
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Mutational probing of protein aggregates to design aggregation‐resistant proteins [PDF]
FEBS Open Bio, 2016 Characterization of amorphous protein aggregates may offer insights into the process of aggregation. Eleven single amino acid mutants of lipase (LipA of Bacillus subtilis) were subjected to temperature‐induced aggregation, and the resultant aggregates were characterized for recovery of activity in the presence of guanidinium chloride (GdmCl).
Mohamad Zahid Kamal +4 more
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Research Progress on the Effects of Parameters of Alkali Extraction and Acid Precipitation on the Denaturation, Aggregation, and Rheological Characteristics of Soybean Protein Isolate [PDF]
Shipin KexuepH, NaCl and temperature are important process parameters for the manufacturing of soybean protein isolate (SPI). pH and NaCl affect protein aggregation by modifying the surface charge and electrostatic repulsion, whereas temperature affects protein ...
MENG Ang, LUAN Binyu, GUO Boli, ZHANG Bo, YU Wenhua, CUI Kai
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A novel approach for the purification of aggregation prone proteins.
PLoS ONE, 2021 The protein aggregation is one of the major challenges of the biotechnological industry, especially in the areas of development and commercialization of successful protein-based drug products.
Austin Royster +2 more
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Pathological AT1R-B2R Protein Aggregation and Preeclampsia
Cells, 2021 Preeclampsia is one of the most frequent and severe complications of pregnancy. Symptoms of preeclampsia usually occur after 20 weeks of pregnancy and include hypertension and kidney dysfunction with proteinuria.
Ursula Quitterer, Said AbdAlla
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Localization of protein aggregation in Escherichia coli is governed by diffusion and nucleoid macromolecular crowding effect [PDF]
, 2013 Aggregates of misfolded proteins are a hallmark of many age-related diseases. Recently, they have been linked to aging of Escherichia coli (E. coli) where protein aggregates accumulate at the old pole region of the aging bacterium.
Berry, Hugues +8 more
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