eLife, 2022 A loss of the checkpoint kinase ataxia telangiectasia mutated (ATM) leads to impairments in the DNA damage response, and in humans causes cerebellar neurodegeneration, and an increased risk of cancer.
Wouter Huiting +16 more
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Protein folding disorders: Toward a basic biological paradigm [PDF]
, 2010 Mechanistic 'physics' models of protein folding fail to account for the observed spectrum of protein folding and aggregation disorders, suggesting that a more appropriately biological paradigm will be needed for understanding the etiology ...
Rodrick Wallace
core +3 more sources
Small heat-shock proteins: important players in regulating cellular proteostasis [PDF]
, 2015 Small heat-shock proteins (sHsps) are a diverse family of intra-cellular molecular chaperone proteins that play a critical role in mitigating and preventing protein aggregation under stress conditions such as elevated temperature, oxidation and infection.
Carver, John A. +3 more
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AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides
BMC Bioinformatics, 2007 Background Protein aggregation correlates with the development of several debilitating human disorders of growing incidence, such as Alzheimer's and Parkinson's diseases.
Vendrell Josep +5 more
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The regions of the sequence most exposed to the solvent within the amyloidogenic state of a protein initiate the aggregation process. [PDF]
, 2004 Formation of misfolded aggregates is an essential part of what proteins can do. The process of protein aggregation is central to many human diseases and any aggregating event needs to be prevented within a cell and in protein design.
AMORESANO, ANGELA +6 more
core +1 more source
Protein accumulation in the endoplasmic reticulum as a non-equilibrium phase transition [PDF]
, 2014 Several neurological disorders are associated with the aggregation of aberrant proteins, often localized in intracellular organelles such as the endoplasmic reticulum.
Budrikis, Z. +3 more
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Mutational probing of protein aggregates to design aggregation‐resistant proteins [PDF]
FEBS Open Bio, 2016 Characterization of amorphous protein aggregates may offer insights into the process of aggregation. Eleven single amino acid mutants of lipase (LipA of Bacillus subtilis) were subjected to temperature‐induced aggregation, and the resultant aggregates were characterized for recovery of activity in the presence of guanidinium chloride (GdmCl).
Mohamad Zahid Kamal +4 more
openaire +3 more sources
Pathological AT1R-B2R Protein Aggregation and Preeclampsia
Cells, 2021 Preeclampsia is one of the most frequent and severe complications of pregnancy. Symptoms of preeclampsia usually occur after 20 weeks of pregnancy and include hypertension and kidney dysfunction with proteinuria.
Ursula Quitterer, Said AbdAlla
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Localization of protein aggregation in Escherichia coli is governed by diffusion and nucleoid macromolecular crowding effect [PDF]
, 2013 Aggregates of misfolded proteins are a hallmark of many age-related diseases. Recently, they have been linked to aging of Escherichia coli (E. coli) where protein aggregates accumulate at the old pole region of the aging bacterium.
Berry, Hugues +8 more
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Research Progress on the Effects of Parameters of Alkali Extraction and Acid Precipitation on the Denaturation, Aggregation, and Rheological Characteristics of Soybean Protein Isolate [PDF]
Shipin KexuepH, NaCl and temperature are important process parameters for the manufacturing of soybean protein isolate (SPI). pH and NaCl affect protein aggregation by modifying the surface charge and electrostatic repulsion, whereas temperature affects protein ...
MENG Ang, LUAN Binyu, GUO Boli, ZHANG Bo, YU Wenhua, CUI Kai
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