Results 71 to 80 of about 737,165 (295)

Nanoparticles in relation to peptide and protein aggregation

International Journal of Nanomedicine, 2014
Masihuz Zaman, Ejaz Ahmad, Atiyatul Qadeer, Gulam Rabbani, Rizwan Hasan Khan Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India Abstract: Over the past two decades, there has been considerable research interest in the use of
Zaman M, Ahmad E, Qadeer A, Rabbani G, Khan RH   +4 more
doaj  

Amyloidogenic regions and interaction surfaces overlap in globular proteins related to conformational diseases. [PDF]

PLoS Computational Biology, 2009
Protein aggregation underlies a wide range of human disorders. The polypeptides involved in these pathologies might be intrinsically unstructured or display a defined 3D-structure.
Virginia Castillo, Salvador Ventura
doaj   +1 more source

Sensitive, homogeneous, and label-free protein-probe assay for antibody aggregation and thermal stability studies

mAbs, 2021
Protein aggregation is a spontaneous process affected by multiple external and internal properties, such as buffer composition and storage temperature.
Salla Valtonen, Emmiliisa Vuorinen, Ville Eskonen, Morteza Malakoutikhah, Kari Kopra, Harri Härmä   +5 more
doaj   +1 more source

Protein structure and phenotypic analysis of pathogenic and population missense variants in STXBP1 [PDF]

, 2017
Background: Syntaxin-binding protein 1, encoded by STXBP1, is highly expressed in the brain and involved in fusing synaptic vesicles with the plasma membrane.
Baker, K, Clayton-Smith, J, Dabir, T, DDD Study, Evers, JMG, Josifova, D, Joss, S, Kerr, B, Kraus, A, Laskowski, RA, McEntagart, M, Morton, J, O'Brien, S, Smith, A, Splitt, M, Suri, M, Thornton, JM, Wright, CF   +17 more
core   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Anti-aggregation effect of Ascorbic Acid and Quercetin on aggregated Bovine Serum Albumin Induced by Dithiothreitol: Comparison of Turbidity and Soluble Protein Fraction Methods

Jurnal Kimia Sains dan Aplikasi, 2020
Studies on the anti-aggregation of dithiothreitol (DTT) induced - protein is generally determined by the fraction soluble (non-aggregated) protein. While the turbidity method is commonly used in studies of anti-aggregation, in which protein is induced by
Amat Rifai, Mukhammad Asy'ari, Agustina L. N. Aminin   +2 more
doaj   +1 more source

Lipid-protein interaction induced domains: kinetics and conformational changes in multicomponent vesicles

, 2018
The spatio-temporal organization of proteins and the associated morphological changes in membranes are of importance in cell signaling. Several mechanisms that promote the aggregation of proteins at low cell surface concentrations have been investigated ...
Kumar, P. B. Sunil, Sreeja, K. K.
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Kinetics of Thermal Denaturation and Aggregation of Bovine Serum Albumin. [PDF]

PLoS ONE, 2016
Thermal aggregation of bovine serum albumin (BSA) has been studied using dynamic light scattering, asymmetric flow field-flow fractionation and analytical ultracentrifugation. The studies were carried out at fixed temperatures (60°C, 65°C, 70°C and 80°C)
Vera A Borzova, Kira A Markossian, Natalia A Chebotareva, Sergey Yu Kleymenov, Nikolay B Poliansky, Konstantin O Muranov, Vita A Stein-Margolina, Vladimir V Shubin, Denis I Markov, Boris I Kurganov   +9 more
doaj   +1 more source

Unraveling the mechanism of tau protein aggregation in presence of zinc ion: The earliest step of tau aggregation

Chemical Physics Impact, 2022
Recent studies have indicated that tau protein aggregation is closely related to Alzheimer's disease. Though the later stages of the aggregation process are extensively studied, it is still unknown how the aggregation occurs in the earliest stage.
S. Roy Chowdhury, H. Peter Lu
doaj   +1 more source