Results 71 to 80 of about 7,628,689 (242)

Dynamic fluctuations of protein-carbohydrate interactions promote protein aggregation. [PDF]

PLoS ONE, 2009
Protein-carbohydrate interactions are important for glycoprotein structure and function. Antibodies of the IgG class, with increasing significance as therapeutics, are glycosylated at a conserved site in the constant Fc region.
Vladimir Voynov, Naresh Chennamsetty, Veysel Kayser, Bernhard Helk, Kurt Forrer, Heidi Zhang, Cornelius Fritsch, Holger Heine, Bernhardt L Trout   +8 more
doaj   +1 more source

Causative Links between Protein Aggregation and Oxidative Stress: A Review

International Journal of Molecular Sciences, 2019
Compelling evidence supports a tight link between oxidative stress and protein aggregation processes, which are noticeably involved in the development of proteinopathies, such as Alzheimer’s disease, Parkinson’s disease, and prion disease. The literature
Elise Lévy, Nadine El Banna, Dorothée Baïlle, Amélie Heneman-Masurel, S. Truchet, H. Rezaei, Meng-Er Huang, V. Béringue, D. Martin, L. Vernis   +9 more
semanticscholar   +1 more source

Aging and the aggregating proteome

Frontiers in Genetics, 2012
For all organisms promoting protein homeostasis is a high priority in order to optimize cellular functions and resources. However, there is accumulating evidence that aging leads to a collapse in protein homeostasis and widespread non-disease protein ...
Della C David
doaj   +1 more source

FAIM Opposes Aggregation of Mutant SOD1 That Typifies Some Forms of Familial Amyotrophic Lateral Sclerosis

Frontiers in Neuroscience, 2020
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative illness that is unremittingly fatal and for which no effective treatment exists. All forms of ALS are characterized by protein aggregation.
Hiroaki Kaku, Hiroaki Kaku, Alexander V. Ludlow, Michael F. Gutknecht, Thomas L. Rothstein, Thomas L. Rothstein   +5 more
doaj   +1 more source

Adenosine Triphosphate (ATP) and Protein Aggregation in Age-Related Vision-Threatening Ocular Diseases

Metabolites, 2023
Protein aggregation is the etiopathogenesis of the three most profound vision-threatening eye diseases: age-related cataract, presbyopia, and age-related macular degeneration.
Jack V. Greiner, Thomas Glonek
doaj   +1 more source

Enrichment and aggregation of topological motifs are independent organizational principles of integrated interaction networks

, 2011
Topological network motifs represent functional relationships within and between regulatory and protein-protein interaction networks. Enriched motifs often aggregate into self-contained units forming functional modules.
Anagha Joshi, Björklund, Brin, Bruno Nachtergaele, Csikász-Nagy, De Lathauwer, de Lichtenberg, Dobrin, Fiedler, Harbison, Hartwell, Huang, Kalir, Kashtan, Kashtan, Kellog, Kleinberg, Kraemer, Lee, Lee, Loch, Mazurie, McClellan, Mendenhall, Milo, Neely, Newman, Planta, Ptacek, Ravasz, Reguly, Shen-Orr, Solé, Solé, Spellman, Stark, Tan, Tom Michoel, Vázquez, Yeger-Lotem, Yeger-Lotem, Yosef, Yu, Yves Van de Peer, Zhang, Zhao   +45 more
core   +2 more sources

Protein aggregates in Huntington's disease [PDF]

Experimental Neurology, 2012
Huntington's disease (HD) is an incurable neurodegenerative disease characterized by abnormal motor movements, personality changes, and early death. HD is caused by a mutation in the IT-15 gene that expands abnormally the number of CAG nucleotide repeats.
Arrasate, Montserrat, Finkbeiner, Steven
openaire   +4 more sources

Data on correlation between Aβ42 structural aggregation propensity and toxicity in bacteria

Data in Brief, 2016
Protein aggregation and amyloid formation is a hallmark of an increasing number of human disorders. Because protein aggregation is deleterious for the cell physiology and results in a decrease in overall cell fitness, it is thought that natural selection
Anita Carija, Susanna Navarro, Salvador Ventura   +2 more
doaj   +1 more source

A novel approach for the purification of aggregation prone proteins.

PLoS ONE, 2021
The protein aggregation is one of the major challenges of the biotechnological industry, especially in the areas of development and commercialization of successful protein-based drug products.
Austin Royster, Sheema Mir, Mohammad Ayoub Mir   +2 more
doaj   +1 more source

The role of glia in protein aggregation.

Neurobiology of Disease, 2020
Protein aggregation diseases involve intracellular accumulation or extracellular deposition of certain protein species in neuronal or glial cells, leading to neurodegeneration and shortened lifespan.
Qingyun Li, Michael S. Haney
semanticscholar   +1 more source