Results 51 to 60 of about 2,677,114 (323)

A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation

BMC Cancer, 2014
BackgroundOvarian cancer is now recognized as a number of distinct diseases primarily defined by histological subtype. Both clear cell ovarian carcinomas (CCC) and ovarian endometrioid carcinomas (EC) may arise from endometriosis and frequently harbor ...
Kimberly C. Wiegand, B. Hennessy, S. Leung, Yemin Wang, Z. Ju, Mollianne J. McGahren, S. Kalloger, Sarah J. Finlayson, K. Stemke‐Hale, Yiling Lu, Fan Zhang, M. Anglesio, B. Gilks, G. Mills, D. Huntsman, M. Carey   +15 more
semanticscholar   +1 more source

LPS-induced TNF-α factor mediates pro-inflammatory and pro-fibrogenic pattern in non-alcoholic fatty liver disease [PDF]

, 2015
Lipopolysaccharide (LPS) is currently considered one of the major players in non-alcoholic fatty liver disease (NAFLD) pathogenesis and progression.
Agostinelli, Laura, Alisi, Anna, Bruscalupi, Giovannella, Ceccarelli, Sara, Crudele, Annalisa, Cucchiara, Salvatore, De Stefanis, Cristiano, Furlanello, Cesare, Gnani, Daniela, Mina, Marco, Musso, Giovanni, Nobili, Valerio, Panera, Nadia, Petrini, Stefania, Rychlicki, Chiara, Stronati, Laura, Svegliati Baroni, Gianluca   +16 more
core   +2 more sources

Rare osteosarcoma cell subpopulation protein array and profiling using imaging mass cytometry and bioinformatics analysis

BMC Cancer, 2020
Background Single rare cell characterization represents a new scientific front in personalized therapy. Imaging mass cytometry (IMC) may be able to address all these questions by combining the power of MS-CyTOF and microscopy.
Izhar S. Batth, Qing Meng, Qi Wang, Keila E. Torres, Jared Burks, Jing Wang, Richard Gorlick, Shulin Li   +7 more
doaj   +1 more source

Microstructured blood vessel surrogates reveal structural tropism of motile malaria parasites [PDF]

, 2017
Plasmodium sporozoites, the highly motile forms of the malaria parasite, are transmitted naturally by mosquitoes and traverse the skin to find, associate with, and enter blood capillaries.
Battista, Anna, Dahan, Noa, Fackler, Oliver T., Frischknecht, Friedrich, Haraszti, Tamas, Hellmann, Janina K., Lemgruber, Leandro, Muthinja, Mendi J., Ripp, Johanna, Schwarz, Ulrich S., Schütz, Lucas, Spatz, Joachim P.   +11 more
core   +1 more source

Bioinformatics analysis of mitochondrial encephalomyopathy with lactic acidemia and stroke⁃like episodes geneome microarray based on GEO database

Chinese Journal of Contemporary Neurology and Neurosurgery, 2020
Objective To investigate the possible pathogenesis and clinical feature of mitochondrial encephalomyopathy with lactic acidemia and stroke ⁃ like episodes (MELAS) on the molecular level by bioinformatics analysis of differential expression genes. Methods
Qian XU, Yang GAO, Lei LI, Jun YAN, Li⁃ling WANG, Tao⁃jie REN   +5 more
doaj  

Proteomics, pathway array and signaling network-based medicine in cancer

Cell Division, 2009
Cancer is a multifaceted disease that results from dysregulated normal cellular signaling networks caused by genetic, genomic and epigenetic alterations at cell or tissue levels. Uncovering the underlying protein signaling network changes, including cell
Xu Hong, Liu Wei, Song Dong, Wu Josephine, Wang Libo, Wang Hongxia, Che Yufang, Zhao Xin, Liu Xiaoliang, Gao Ling, Ye Fei, Zhang David Y, Jiang Bo, Zhang Weijia, Wang Jinhua, Lee Peng   +15 more
doaj   +1 more source

Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels [PDF]

, 2007
Disrupted-in-schizophrenia 1 (DISC1) is a genetic susceptibility factor for schizophrenia and related severe psychiatric conditions. DISC1 is a multifunctional scaffold protein that is able to interact with several proteins, including the independently ...
Bolger, G.B., Collins, D.M., Hill, E.V., Houslay, M.D., Klussmann, E., Mackie, S., Millar, J.K., Murdoch, H., Porteous, D.J.   +8 more
core   +1 more source

The bromodomain-containing protein Ibd1 links multiple chromatin related protein complexes to highly expressed genes in Tetrahymena thermophila

, 2018
Background: The chromatin remodelers of the SWI/SNF family are critical transcriptional regulators. Recognition of lysine acetylation through a bromodomain (BRD) component is key to SWI/SNF function; in most eukaryotes, this function is attributed to ...
Burtch, Alyson, Fillingham, Jeffrey, Garg, Jyoti, Gingras, Anne-Claude, Lambert, Jean-Philippe, Mudalige, Cristina Thuppu, Nabeel-Shah, Syed, Pearlman, Ronald E., Ponce, Marcelo, Saettone, Alejandro   +9 more
core   +1 more source

A combined computational-experimental approach to define the structural origin of antibody recognition of sialyl-Tn, a tumor-associated carbohydrate antigen. [PDF]

, 2018
Anti-carbohydrate monoclonal antibodies (mAbs) hold great promise as cancer therapeutics and diagnostics. However, their specificity can be mixed, and detailed characterization is problematic, because antibody-glycan complexes are challenging to ...
Amon, Ron, Chen, Xi, Fleishman, Sarel J, Glushka, John N, Grant, Oliver C, Leviatan Ben-Arye, Shani, Makeneni, Spandana, Marshanski, Tal, Nivedha, Anita K, Norn, Christoffer, Padler-Karavani, Vered, Woods, Robert J, Yu, Hai   +12 more
core   +2 more sources

A Metabolomics Investigation of the Metabolic Changes of Raji B Lymphoma Cells Undergoing Apoptosis Induced by Zinc Ions

Metabolites, 2021
Zinc plays a pivotal role in the function of cells and can induce apoptosis in various cancer cells, including Raji B lymphoma. However, the metabolic mechanism of Zn-induced apoptosis in Raji cells has not been explored.
Naeun Yoon, Hyunbeom Lee, Geonhee Lee, Eun Hye Kim, Seong Hwan Kim, Jeong-O Lee, Yunseon Song, Jinyoung Park, So-Dam Kim, Yeojin Kim, Byung Hwa Jung   +10 more
doaj   +1 more source