Results 1 to 10 of about 11,837,096 (346)

A Preclinical Study Comparing the Activity and Potency of OnabotulinumtoxinA and PrabotulinumtoxinA

Clinical, Cosmetic and Investigational Dermatology, 2023
David C Rupp, David Canty, Catherine Rhéaume, Birgitte Sondergaard, Celina Niño, Ron S Broide, Amy D Brideau-Andersen Allergan Aesthetics, an AbbVie Company, Irvine, CA, USACorrespondence: David C Rupp, Allergan Aesthetics, an AbbVie Company, 2525 Dupont
Rupp DC, Canty D, Rhéaume C, Sondergaard B, Niño C, Broide RS, Brideau-Andersen AD   +6 more
doaj  

Preclinical Pharmacology of BA-TPQ, a Novel Synthetic Iminoquinone Anticancer Agent

Marine Drugs, 2010
Marine natural products and their synthetic derivatives represent a major source of novel candidate anti-cancer compounds. We have recently tested the anti-cancer activity of more than forty novel compounds based on an iminoquinone makaluvamine scaffold,
Ruiwen Zhang, Wei Wang, Sadanandan E. Velu, Xinyi Yang, Charnell I. Sommers, Elizabeth R. Rayburn, Xu Zhang, Evrim Gurpinar, Hongxia Xu, Xiangrong Zhang, Scharri J. Ezell, Haibo Li   +11 more
doaj   +1 more source

Protein Binding Domain

Definitions, 2020
Protein Binding Domains are structural motifs responsible for the peptide/protein binding activity of proteins.

semanticscholar   +1 more source

SCRIBER: accurate and partner type-specific prediction of protein-binding residues from proteins sequences

Bioinform., 2019
Motivation Accurate predictions of protein-binding residues (PBRs) enhances understanding of molecular-level rules governing protein–protein interactions, helps protein–protein docking and facilitates annotation of protein functions.
Jian Zhang, Lukasz Kurgan
semanticscholar   +1 more source

Chemical Attachment of 5-Nitrosalicylaldimine Motif to Silatrane Resulting in an Organic–Inorganic Structure with High Medicinal Significance

Pharmaceutics, 2022
Two chemical motifs of interest for medicinal chemistry, silatrane as 1-(3-aminopropyl) silatrane (SIL M), and nitro group attached in position 5 to salicylaldehyde, are coupled in a new structure, 1-(3-{[(2-hydroxy-5-nitrophenyl)methylidene]amino}propyl)
Mirela-Fernanda Zaltariov, Mihaela Turtoi, Dragos Peptanariu, Ana-Maria Macsim, Lilia Clima, Corneliu Cojocaru, Nicoleta Vornicu, Bianca-Iulia Ciubotaru, Alexandra Bargan, Manuela Calin, Maria Cazacu   +10 more
doaj   +1 more source

A Kinetic Transition Network Model Reveals the Diversity of Protein Dimer Formation Mechanisms

Biomolecules, 2023
Protein homodimers have been classified as three-state or two-state dimers depending on whether a folded monomer forms before association, but the details of the folding–binding mechanisms are poorly understood.
Dániel Györffy, Péter Závodszky, András Szilágyi   +2 more
doaj   +1 more source

DeeplyTough: Learning Structural Comparison of Protein Binding Sites

bioRxiv, 2019
Motivation Protein binding site comparison (pocket matching) is of importance in drug discovery. Identification of similar binding sites can help guide efforts for hit finding, understanding polypharmacology and characterization of protein function.
Martin Simonovsky, Joshua Meyers
semanticscholar   +1 more source

Collagen binding proteins

Osteoarthritis and Cartilage, 2001
The connective tissues are crucial for multicellular organisms, playing many diverse roles both structurally and mechanically as well as providing a protective function. They make up the frame of the mammalian body and add strength and elasticity, while their protective function is important both on the outside of the body and inside, where they ...
Svensson, L., Oldberg, Å., Heinegård, D.   +2 more
openaire   +2 more sources

SKEMPI 2.0: an updated benchmark of changes in protein–protein binding energy, kinetics and thermodynamics upon mutation

bioRxiv, 2018
Motivation Understanding the relationship between the sequence, structure, binding energy, binding kinetics and binding thermodynamics of protein-protein interactions is crucial to understanding cellular signaling, the assembly and regulation of ...
Justina Jankauskaite, Brian Jiménez-García, J. Dapkūnas, J. Fernández-Recio, I. Moal   +4 more
semanticscholar   +1 more source

Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine

Cellular & Molecular Immunology, 2020
The outbreak of Coronavirus Disease 2019 (COVID-19) has posed a serious threat to global public health, calling for the development of safe and effective prophylactics and therapeutics against infection of its causative agent, severe acute respiratory ...
Wanbo Tai, Lei He, Xiujuan Zhang, J. Pu, D. Voronin, Shibo Jiang, Yusen Zhou, L. Du   +7 more
semanticscholar   +1 more source