Results 1 to 10 of about 4,013,382 (355)

Computational Approach to Drug Penetration across the Blood-Brain and Blood-Milk Barrier Using Chromatographic Descriptors

Cells, 2023
Drug penetration through biological barriers is an important aspect of pharmacokinetics. Although the structure of the blood-brain and blood-milk barriers is different, a connection can be found in the literature between drugs entering the central ...
Wanat Karolina, Rojek Agata, Brzezińska Elżbieta   +2 more
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Milk-Derived Carbon Quantum Dots: Study of Biological and Chemical Properties Provides Evidence of Toxicity

Molecules, 2022
Carbon dots (CDs) are carbon-based zero-dimensional nanomaterials that can be prepared from a number of organic precursors. In this research, they are prepared using fat-free UHT cow milk through the hydrothermal method.
Hasan Shabbir, Konrad Wojtaszek, Bogdan Rutkowski, Edit Csapó, Marek Bednarski, Anita Adamiec, Monika Głuch-Lutwin, Barbara Mordyl, Julia Druciarek, Magdalena Kotańska, Piotr Ozga, Marek Wojnicki   +11 more
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Revisiting the Rate-Limiting Step of the ANS–Protein Binding at the Protein Surface and Inside the Hydrophobic Cavity

Molecules, 2021
8-Anilino-1-naphthalenesulfonic acid (ANS) is used as a hydrophobic fluorescence probe due to its high intensity in hydrophobic environments, and also as a microenvironment probe because of its unique ability to exhibit peak shift and intensity change ...
Chikashi Ota, Shun-ichi Tanaka, Kazufumi Takano   +2 more
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Two phytocompounds from Schinopsis brasiliensis show promising antiviral activity with multiples targets in Influenza A virus

Anais da Academia Brasileira de Ciências, 2021
Influenza A virus, the main flu agent, affects billions of people worldwide. Conventional treatments still present limitations related to drug-resistance and severe side effects.
PEDRO HENRIQUE SETTE-DE-SOUZA, MOAN J.F. COSTA, FÁBIO A.C. ARAÚJO, EVERTON N. ALENCAR, LUCAS AMARAL-MACHADO   +4 more
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An Overview of the Protein Binding of Cephalosporins in Human Body Fluids: A Systematic Review

Frontiers in Pharmacology, 2022
Introduction: Protein binding can diminish the pharmacological effect of beta-lactam antibiotics. Only the free fraction has an antibacterial effect. The aim of this systematic literature review was to give an overview of the current knowledge of protein
C. Jongmans, A. E. Muller, A. E. Muller, P. Van Den Broek, B. De Melo Cruz De Almeida, C. Van Den Berg, J. Van Oldenrijk, P. K. Bos, B. C. P. Koch   +8 more
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PEDOT-Polyamine-Based Organic Electrochemical Transistors for Monitoring Protein Binding

Biosensors, 2023
The fabrication of efficient organic electrochemical transistors (OECTs)-based biosensors requires the design of biocompatible interfaces for the immobilization of biorecognition elements, as well as the development of robust channel materials to enable ...
Marjorie Montero-Jimenez, Francisco L. Amante, Gonzalo E. Fenoy, Juliana Scotto, Omar Azzaroni, Waldemar A. Marmisolle   +5 more
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In Silico Plasma Protein Binding Studies of Selected Group of Drugs Using TLC and HPLC Retention Data

Pharmaceuticals, 2021
Plasma protein binding is an important determinant of the pharmacokinetic properties of chemical compounds in living organisms. The aim of the present study was to determine the index of protein binding affinity based on chromatographic experiments.
Karolina Wanat, Grażyna Żydek, Adam Hekner, Elżbieta Brzezińska   +3 more
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Reducing Unspecific Protein Adsorption in Microfluidic Papers Using Fiber-Attached Polymer Hydrogels

Sensors, 2021
Microfluidic paper combines pump-free water transport at low cost with a high degree of sustainability, as well as good availability of the paper-forming cellulosic material, thus making it an attractive candidate for point-of-care (POC) analytics and ...
Alexander Ritter von Stockert, Anna Luongo, Markus Langhans, Thomas Brandstetter, Jürgen Rühe, Tobias Meckel, Markus Biesalski   +6 more
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Preclinical Pharmacology of BA-TPQ, a Novel Synthetic Iminoquinone Anticancer Agent

Marine Drugs, 2010
Marine natural products and their synthetic derivatives represent a major source of novel candidate anti-cancer compounds. We have recently tested the anti-cancer activity of more than forty novel compounds based on an iminoquinone makaluvamine scaffold,
Ruiwen Zhang, Wei Wang, Sadanandan E. Velu, Xinyi Yang, Charnell I. Sommers, Elizabeth R. Rayburn, Xu Zhang, Evrim Gurpinar, Hongxia Xu, Xiangrong Zhang, Scharri J. Ezell, Haibo Li   +11 more
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Statistical Methods in the Study of Protein Binding and Its Relationship to Drug Bioavailability in Breast Milk

Molecules, 2022
Protein binding (PB) is indicated as the factor most severely limiting distribution in the organism, reducing the bioavailability of the drug, but also minimizing the penetration of xenobiotics into the fetus or the body of a breastfed child.
Karolina Wanat, Elżbieta Brzezińska
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