Results 181 to 190 of about 11,837,096 (346)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

A Quantum Framework for Protein Binding-Site Structure Prediction on Utility-Level Quantum Processors. [PDF]

Adv Sci (Weinh)
Zhang Y, Yang Y, Martin W, Lin K, Wang Z, Lu CC, Jiang W, Nussinov R, Loscalzo J, Guan Q, Cheng F.   +10 more
europepmc   +1 more source

Estrogen-binding Proteins

Folia Endocrinologica Japonica, 1968
S, Yoshinaga, H, Takikawa
openaire   +3 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Crystallographic and computational investigation of a bent-core Schiff base Ni(ii) complex with DNA and protein binding studies. [PDF]

RSC Adv
Alia KN, Debbarma BK, Nath S, Roy S, Kennedy AR, Adhikari S, Kumar MS, Das AK, Begum S, Mohiuddin G.   +9 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

La protein binding to telomerase RNA supports an evolutionary relationship between plant and ciliate telomerase pathways. [PDF]

Nucleic Acids Res
Jenner L, Pruchkouski D, Štefanovie B, Nováková O, Kubíčková M, Fajkus P, Brázdová M, Paleček J, Sýkorová E.   +8 more
europepmc   +1 more source

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling.

Cell, 1992
A. Ridley, H. Paterson, C. Johnston, D. Diekmann, A. Hall   +4 more
semanticscholar   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Decoding protein binding plasticity via integrated deep ribosome display and deep learning. [PDF]

Commun Biol
Tang M, Li J, Li Z, Cui J, Qi H.
europepmc   +1 more source