Results 211 to 220 of about 10,846,120 (403)

Selectivity determinants of GPCR–G-protein binding

Nature, 2017
T. Flock, A. Hauser, N. Lund, David E. Gloriam, S. Balaji, M. M. Babu   +5 more
semanticscholar   +1 more source

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

Photoswitchable intein for light control of covalent protein binding and cleavage. [PDF]

Nat Commun
Baloban M, Manoilov KY, Karasev MM, Verkhusha VV, Shcherbakova DM.   +4 more
europepmc   +1 more source

Steroid-Protein Interaction with Particular Reference to Testosterone Binding by Human Serum

, 1967
William H. Pearlman, O Crépy
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Editorial: Machine learning in computer-aided drug design

Frontiers in Molecular Biosciences
Ognjen Perišić, Cigdem Sevim Bayrak, Mohamed Khaled Gunady   +2 more
doaj   +1 more source

A nile red fluorescence assay for LC3 autophagy protein binding to lipid bilayers. [PDF]

Sci Rep
Sot J, Varela YR, Montes LR, Goñi FM, Alonso A.   +4 more
europepmc   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Molecule generation for target protein binding with hierarchical consistency diffusion model. [PDF]

Chem Sci
Li G, Jiang C, Gao Z, Liu Y, Liu C, Chen J, Huang Y, Li J.   +7 more
europepmc   +1 more source

Purification and Properties of a Leucine-binding Protein from Escherichia coli

, 1968
W.R. Penrose, George E. Nichoalds, Jeanette R. Piperno, Dale L. Oxender   +3 more
openalex   +1 more source