Results 211 to 220 of about 4,419,405 (356)

Hydroxyl and Trifluoromethyl Radical Carbohydrate Footprinting for Probing Protein Binding Components of Oligosaccharides. [PDF]

Anal Chem
Yusuph Q, Misra SK, Liu H, Sharp JS.
europepmc   +1 more source

Cyclic AMP response element-binding protein prevents endothelial permeability increase through transcriptional controlling p190RhoGAP expression

, 2011
Koteswara R. Chava, Mohammad Tauseef, Tiffany Sharma, Dolly Mehta   +3 more
openalex   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

DNA-Protein Binding is Dominated by Short Anchoring Elements. [PDF]

Adv Sci (Weinh)
Chen H, Xu Y, Ge H, Su XD.
europepmc   +1 more source

Binding of the volatile general anesthetics halothane and isoflurane to a mammalian β‐barrel protein [PDF]

, 2004
Jonas Johansson, Gavin A. Manderson, Roberto Ramoni, Stefano Grolli, Roderic G. Eckenhoff   +4 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Cancer histone mutations impact protein binding and DNA repair with possible links to genomic instability. [PDF]

Nucleic Acids Res
Espiritu D, Sheng Y, Peng Y, Ostroverkhova D, Li S, Landsman D, Aristizabal MJ, Panchenko AR.   +7 more
europepmc   +1 more source

Novel immunogenic T cell epitope of the HBV core protein with multiple overlapping binding registers in HLA-DR13

Schreiber, Sophia, Goeppert, Simone
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

GENEOnet: a breakthrough in protein binding pocket detection using group equivariant non-expansive operators. [PDF]

Sci Rep
Bocchi G, Frosini P, Micheletti A, Pedretti A, Palermo G, Gadioli D, Gratteri C, Lunghini F, Biswas AD, Stouten PFW, Beccari AR, Fava A, Talarico C.   +12 more
europepmc   +1 more source