Results 221 to 230 of about 11,837,096 (346)

GENEOnet: a breakthrough in protein binding pocket detection using group equivariant non-expansive operators. [PDF]

Sci Rep
Bocchi G, Frosini P, Micheletti A, Pedretti A, Palermo G, Gadioli D, Gratteri C, Lunghini F, Biswas AD, Stouten PFW, Beccari AR, Fava A, Talarico C.   +12 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Leveraging large language models for literature-driven prioritization of protein binding pockets. [PDF]

Bioinformatics
Stratiichuk R, Melnychenko M, Koleiev I, Voitsitskyi T, Husak V, Shevchuk N, Ostrovsky Z, Bdzhola V, Yesylevskyy S, Starosyla S, Nafiiev A.   +10 more
europepmc   +1 more source

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.

Cell, 2000
A. Verhagen, P. Ekert, P. Ekert, M. Pakusch, J. Silke, L. Connolly, G. E. Reid, R. Moritz, R. Simpson, D. Vaux   +9 more
semanticscholar   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Adaptation of DNA to Protein Binding Revealed by Spectroscopy and Molecular Simulation. [PDF]

J Phys Chem B
van Heesch T, Sharma S, van Erp B, Ortíz APA, Dame RT, Vreede J, Gavvala K.   +6 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Nuclear Retention of mRNAs Through Paraspeckle Protein Binding to a Sequence Determinant in 3'UTR. [PDF]

Int J Mol Sci
Jacq A, Becquet D, Boyer B, Guillen S, Bello-Goutierrez MM, Blanchard MP, Villard C, Belghazi M, Torres M, Franc JL, François-Bellan AM.   +10 more
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source