Results 31 to 40 of about 4,013,382 (355)

Photoaffinity Labeling of Plasma Proteins

Molecules, 2013
Photoaffinity labeling is a powerful technique for identifying a target protein. A high degree of labeling specificity can be achieved with this method in comparison to chemical labeling.
Masaki Otagiri, Victor Tuan Giam Chuang
doaj   +1 more source

Determination of α1-acid glycoprotein (AGP) concentration by HPLC in patients following local infiltration analgesia for primary total hip arthroplasty and its relation to ropivacaine (total and unbound)

Frontiers in Pharmacology, 2023
Introduction: This study was performed to determine the levels of α1-acid glycoprotein (AGP) in old-age patients undergoing total hip arthroplasty. AGP is considered an acute phase protein produced during the acute phase reaction in the body to various ...
Muhammad Abbas, Manal A. Alossaimi, Abdulmalik S. A. Altamimi, Mai Alajaji, David G. Watson, Sayyed I. Shah, Yasar Shah, Mohammad S. Anwar   +7 more
doaj   +1 more source

Comprehensive structural classification of ligand binding motifs in proteins [PDF]

, 2008
Comprehensive knowledge of protein-ligand interactions should provide a useful basis for annotating protein functions, studying protein evolution, engineering enzymatic activity, and designing drugs.
Akira R. Kinjo, Altschul, Andreeva, Bachhawat, Barber, Berman, Berry, Beuth, Brakoulias, Carvalho, Chen, Davies, Diamond, Dias, Du, Dunn, Friedberg, Garcia-Molina, Gold, Goldstein, Gonzalez, Grishin, Grishin, Gross, Guilloteau, Gutteridge, Haruki Nakamura, Herter, Hoff, Ikura, Jonassen, Jones, Kawabata, Kawabata, Kinjo, Kinoshita, Kinoshita, Kobayashi, Kolodny, Krishna, Krishna, Krissinel, Lang, Laronde-Leblanc, Lawler, Lee, Malikayil, Minai, Murzin, Nagano, Orengo, Pattabhi, Polacco, Porter, Ridder, Rognan, Russell, Schubert, Shulman-Peleg, Standley, Stark, Stewart, Stoll, Tari, Tari, Taylor, Wallace, Wangikar, Watts, Westbrook, Whitlow, Wolfson, Xiao, Xie   +73 more
core   +2 more sources

The Binding of Aripiprazole to Plasma Proteins in Chronic Renal Failure Patients

Toxins, 2021
The binding of drugs to plasma protein is frequently altered in certain types of renal diseases. We recently reported on the effects of oxidation and uremic toxins on the binding of aripiprazole (ARP) to human serum albumin.
Kenshiro Hirata, Tokunori Ikeda, Hiroshi Watanabe, Toru Maruyama, Motoko Tanaka, Victor Tuan Giam Chuang, Yuji Uchida, Keiki Sakurama, Koji Nishi, Keishi Yamasaki, Masaki Otagiri   +10 more
doaj   +1 more source

Total and Free Blood and Plasma Concentration Changes in Pregnancy for Medicines Highly Bound to Plasma Proteins: Application of Physiologically Based Pharmacokinetic Modelling to Understand the Impact on Efficacy

Pharmaceutics, 2023
Free drug concentrations are generally considered the pharmacologically active moiety and are important for cellular diffusion and distribution. Pregnancy-related changes in plasma protein binding and blood partitioning are due to decreases in plasma ...
Paola Coppola, Andrew Butler, Susan Cole, Essam Kerwash   +3 more
doaj   +1 more source

Synthesis, Structural Studies, and Anticancer Properties of [CuBr(PPh₃)₂(4,6-Dimethyl-2-Thiopyrimidine-κS]

Crystals, 2021
CuBr(PPh3)2(4,6-dimethylpyrimidine-2-thione) (Cu-L) was synthesized by stirring CuBr(PPh3)3 and 4,6-dimethylpyrimidine-2-thione in dichloromethane. The crystal structure of Cu-L was obtained, and indicated that the complex adopts a distorted tetrahedral ...
Bandar A. Babgi, Jalal H. Alsayari, Bambar Davaasuren, Abdul-Hamid Emwas, Mariusz Jaremko, Magda H. Abdellattif, Mostafa A. Hussien   +6 more
doaj   +1 more source

The major transcriptional regulatory protein of herpes simplex virus type 1 includes a protease resistant DNA binding domain [PDF]

, 1990
Herpes simplex virus type 1 expresses five immediateearly (IE) polypeptides. In the absence of functional Vmw175 (the product of IE gene 3) activation of transcription of later classes of viral genes and repression of IE gene expression does not occur ...
Elliott, M., Everett, R.D., Paterson, T.
core   +2 more sources

Protein-carbohydrate interactions during fertilization [PDF]

, 1998
Interaction between gametes during fertilization is at least in part regulated by carbohydrate moieties of the zona pellucida (ZP) and carbohydrate binding proteins of the sperm surface. This review focuses on the protein-carbohydrate interactions during
Kolle, S., Plendl, J., Sinowatz, Fred
core   +1 more source

Functional domains of the influenza A virus PB2 protein:identification of NP- and PB1-binding sites [PDF]

, 2004
Influenza virus genomic RNA segments are packaged into ribonucleoprotein (RNP) structures by the PB1, PB2, and PA subunits of an RNA polymerase and a single-strand RNA-binding nucleoprotein (NP).
Digard, Paul, Elton, Debra, Medcalf, Liz, Poole, Emma L   +3 more
core   +1 more source

Protein binding affinity prediction using support vector regression and interfecial features [PDF]

, 2018
In understanding biology at the molecular level, analysis of protein interactions and protein binding affinity is a challenge. It is an important problem in computational and structural biology. Experimental measurement of binding affinity in the wet-lab
Abbasi, W., Minhas, Fayyaz ul Amir Afsar, Yaseen, A.   +2 more
core   +1 more source