Results 31 to 40 of about 807,043 (313)

Segmentation and morphological analysis of amyloid fibrils from cryo-EM image data

Journal of Mathematics in Industry, 2023
Fast assessment of the composition of amyloid fibril samples from cryo-EM data poses a serious challenge to existing image analysis tools. We develop a method for automated segmentation of single fibrils requiring only little user input during the ...
Matthias Weber, Matthias Neumann, Matthias Schmidt, Peter Benedikt Pfeiffer, Akanksha Bansal, Marcus Fändrich, Volker Schmidt   +6 more
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Evolution of an extreme hemoglobin phenotype contributed to the sub-Arctic specialization of extinct Steller’s sea cows

eLife, 2023
The extinct Steller’s sea cow (Hydrodamalis gigas; †1768) was a whale-sized marine mammal that manifested profound morphological specializations to exploit the harsh coastal climate of the North Pacific.
Anthony V Signore, Phillip R Morrison, Colin J Brauner, Angela Fago, Roy E Weber, Kevin L Campbell   +5 more
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BTT305 – Protein Biochemistry (Biokimia Protein) [PDF]

, 2023
Second Semester Examination 2022/2023 Academic Session July/August 2023 BTT305 – Protein Biochemistry (Biokimia Protein) Duration : 2 hours (Masa : 2 ...
PPSKJ, Pusat Pengajian Sains Kajihayat
core  

Characterization of Aptamer-Protein Complexes by X-ray Crystallography and Alternative Approaches [PDF]

, 2012
Aptamers are oligonucleotide ligands, either RNA or ssDNA, selected for high-affinity binding to molecular targets, such as small organic molecules, proteins or whole microorganisms.
Levisson, M., Smidt, H., Ruigrok, V.J.B., Mark Levisson, Dijkstra, B.W., Hekelaar, J., Dijkstra, Bauke W., Hauke Smidt, Ruigrok, Vincent J.B.,, van der Oost, John, Bauke W. Dijkstra, Smidt, Hauke,, Hekelaar, Johan, Dijkstra, Bauke W.,, Hekelaar, Johan,, Vincent J. B. Ruigrok, Levisson, Mark,, Oost, J., van der, Levisson, Mark, Smidt, Hauke, Johan Hekelaar, John Van der Oost, van der Oost, J., Oost, John van der,, Ruigrok, Vincent J. B.   +24 more
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Golgi membrane fission requires the CtBP1-S/BARS-induced activation of lysophosphatidic acid acyltransferase δ

Nature Communications, 2016
CtBP1-S/BARS is required for fission of endomembrane compartments including the Golgi. Here the authors show that CtBP1-S/BARS activates a trans-Golgi lysophosphatidic acid acyltransferase that catalyses the production of phosphatidic acid and is ...
Alessandro Pagliuso, Carmen Valente, Lucia Laura Giordano, Angela Filograna, Guiling Li, Diego Circolo, Gabriele Turacchio, Vincenzo Manuel Marzullo, Luigi Mandrich, Mikhail A. Zhukovsky, Fabio Formiggini, Roman S. Polishchuk, Daniela Corda, Alberto Luini   +13 more
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Cryo-EM structure and polymorphic maturation of a viral transduction enhancing amyloid fibril

Nature Communications, 2023
Amyloid fibrils have emerged as innovative tools to enhance the transduction efficiency of retroviral vectors in gene therapy strategies. In this study, we used cryo-electron microscopy to analyze the structure of a biotechnologically engineered peptide ...
Thomas Heerde, Desiree Schütz, Yu-Jie Lin, Jan Münch, Matthias Schmidt, Marcus Fändrich   +5 more
doaj   +1 more source

Protein Folding and Macromolecular Dynamics: Fundamental Limits of Length and Time Scales [PDF]

, 2012
In this thesis, physics-based models of protein folding at the secondary and tertiary level are developed to resolve long-standing issues of protein folding kinetics.
Lin, Milo Miaoyu
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Motivated proteins: a web application for studying small three-dimensional protein motifs [PDF]

, 2009
<b>BACKGROUND:</b> Small loop-shaped motifs are common constituents of the three-dimensional structure of proteins. Typically they comprise between three and seven amino acid residues, and are defined by a combination of dihedral angles and ...
Milner-White, E.J., Leader David P, David P Leader, Milner-White E James, E James Milner-White, Leader, D.P.   +5 more
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Computational Protein Design Force Field Optimization: A Negative Design Approach [PDF]

, 2007
An accurate force field is essential to computational protein design and protein folding studies. Proper force field tuning is problematic, however, due in part to the incomplete modeling of the unfolded state.
Alvizo, Oscar
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Rapid assessment of DCLK1 inhibitors using a peptide substrate mobility shift assay

STAR Protocols, 2021
Summary: Peptide mobility shift assays provide a sensitive measure of kinase enzymatic activity and can be used to evaluate kinase inhibitors. Herein, we describe a protocol adapted for rapid assessment of doublecortin-like kinase inhibitors.
Yan Liu, Kenneth D. Westover
doaj   +1 more source