Results 11 to 20 of about 754,932 (265)
Common transthyretin-derived amyloid fibril structures in patients with hereditary ATTR amyloidosis
Nature Communications, 2023 Systemic ATTR amyloidosis is an increasingly important protein misfolding disease that is provoked by the formation of amyloid fibrils from transthyretin protein.
Maximilian Steinebrei +8 more
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Comparative biochemistry of antarctic proteins
Comparative Biochemistry and Physiology Part A: Physiology, 1976 The UCD team of agricultural scientists has been studying the proteins of Antarctic species for 11 years, starting in 1964. During the first seven years, trips were made each year to Antarctica to study and obtain specimens from penguins and cold-adapted fishes.
R Feeney, D Osuga
openaire +3 more sources
EFSA Journal, 2018 The goal of this research is to better address the problems related to the widespread presence of pesticides in the environment. Despite the unquestionable utility of the pesticides against various pests in the agricultural field, most pesticides and the
Institute of Protein Biochemistry – National Research Council, Naples, Italy +2 more
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Preparation of Golgi Membranes from Rat Liver
Bio-Protocol, 2014 This protocol details the isolation of enriched Golgi membranes from rat liver, using discontinuous density gradient centrifugation. This high-yield extraction method is useful for several applications, including immunoprecipitation of solubilised Golgi ...
Carmen Valente +4 more
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Segmentation and morphological analysis of amyloid fibrils from cryo-EM image data
Journal of Mathematics in Industry, 2023 Fast assessment of the composition of amyloid fibril samples from cryo-EM data poses a serious challenge to existing image analysis tools. We develop a method for automated segmentation of single fibrils requiring only little user input during the ...
Matthias Weber +6 more
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eLife, 2023 The extinct Steller’s sea cow (Hydrodamalis gigas; †1768) was a whale-sized marine mammal that manifested profound morphological specializations to exploit the harsh coastal climate of the North Pacific.
Anthony V Signore +5 more
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Nature Communications, 2016 CtBP1-S/BARS is required for fission of endomembrane compartments including the Golgi. Here the authors show that CtBP1-S/BARS activates a trans-Golgi lysophosphatidic acid acyltransferase that catalyses the production of phosphatidic acid and is ...
Alessandro Pagliuso +13 more
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Cryo-EM structure and polymorphic maturation of a viral transduction enhancing amyloid fibril
Nature Communications, 2023 Amyloid fibrils have emerged as innovative tools to enhance the transduction efficiency of retroviral vectors in gene therapy strategies. In this study, we used cryo-electron microscopy to analyze the structure of a biotechnologically engineered peptide ...
Thomas Heerde +5 more
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Rapid assessment of DCLK1 inhibitors using a peptide substrate mobility shift assay
STAR Protocols, 2021 Summary: Peptide mobility shift assays provide a sensitive measure of kinase enzymatic activity and can be used to evaluate kinase inhibitors. Herein, we describe a protocol adapted for rapid assessment of doublecortin-like kinase inhibitors.
Yan Liu, Kenneth D. Westover
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MHC class II complexes sample intermediate states along the peptide exchange pathway
Nature Communications, 2016 MHCII proteins bind and present both foreign and self-antigens to potentially activate CD4+ T cells via cognate T cell receptors (TCRs) during the adaptive immune response.
Marek Wieczorek +8 more
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