Results 81 to 90 of about 751,544 (357)

Applications of machine Learning to improve the efficiency and range of microbial biosynthesis: a review of state-of-art techniques [PDF]

arXiv, 2023
In the modern world, technology is at its peak. Different avenues in programming and technology have been explored for data analysis, automation, and robotics. Machine learning is key to optimize data analysis, make accurate predictions, and hasten/improve existing functions.
arxiv  

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

Molecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam, Salem Chouaib, Mohammad Askandar Iqbal   +2 more
wiley   +1 more source

Metabolic modeling and analysis of the metabolic switch in Streptomyces coelicolor [PDF]

, 2010
Background The transition from exponential to stationary phase in Streptomyces coelicolor is accompanied by a major metabolic switch and results in a strong activation of secondary metabolism.
Alam, Mohammad T., Breitling, Rainer, HASH(0x55aa09327868), Hodgson, D. A., Merlo, Maria E., Takano, Eriko, Wellington, E. M. H.   +6 more
core   +9 more sources

Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance

Molecular Oncology, EarlyView.
In this research, we analyzed the relationship between gut microbiota and tumor. We discovered that both subcutaneous and metastatic tumors would alter the composition and metabolic function of gut microbiota. Meanwhile, fecal microbiota transplantation also indicated the anti‐tumor role of the gut microbiota, revealing the crosstalk between tumor and ...
Siyuan Zhang, Haimei Wen, Ying Chen, Jingya Ning, Di Hu, Yujiao Dong, Chenyu Yao, Bo Yuan, Shuanying Yang   +8 more
wiley   +1 more source

Finding New Cell Wall Regulatory Genes in Populus trichocarpa Using Multiple Lines of Evidence. [PDF]

, 2019
Understanding the regulatory network controlling cell wall biosynthesis is of great interest in Populus trichocarpa, both because of its status as a model woody perennial and its importance for lignocellulosic products.
Chen, Jin-Gui, DiFazio, Stephen, Dixon, Richard A, Furches, Anna, Gazolla, Joao Gabriel Felipe Machado, Jacobson, Daniel, Jones, Piet, Joubert, Wayne, Kainer, David, Large, Annabel, Macaya-Sanz, David, Martin, Madhavi Z, Ranjan, Priya, Rao, Xiaolan, Romero, Jonathon, Schmutz, Jeremy, Shah, Manesh, Sreedasyam, Avinash, Streich, Jared, Tschaplinski, Timothy J, Tuskan, Gerald A, Walker, Angelica M, Weighill, Deborah, Zhao, Nan   +23 more
core   +3 more sources

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

A translation proofreader of archaeal origin imparts multi-aldehyde stress tolerance to land plants

eLife
Aldehydes, being an integral part of carbon metabolism, energy generation, and signalling pathways, are ingrained in plant physiology. Land plants have developed intricate metabolic pathways which involve production of reactive aldehydes and its ...
Pradeep Kumar, Ankit Roy, Shivapura Jagadeesha Mukul, Avinash Kumar Singh, Dipesh Kumar Singh, Aswan Nalli, Pujaita Banerjee, Kandhalu Sagadevan Dinesh Babu, Bakthisaran Raman, Shobha P Kruparani, Imran Siddiqi, Rajan Sankaranarayanan   +11 more
doaj   +1 more source

Evolution of substrate specificity in a recipient's enzyme following horizontal gene transfer [PDF]

, 2013
Despite the prominent role of horizontal gene transfer (HGT) in shaping bacterial metabolism, little is known about the impact of HGT on the evolution of enzyme function.
Abascal, Aldo R. Camacho-Zarco, Barona-Gomez, Brune, Carver, Collaborative Computational Project, Number 4 (CCP4), Dean, Depristo, Des Marais, Dittmar, Due, Francisco Barona-Gómez, Glykos, Guindon, Henn-Sax, Hess, Hodgson, Hu, Hughes, Humphrey, Ikeda, James, Jensen, Jensen, Jones, Jorgensen, Jung, Kane, Klassen, Kuper, Leaver-Fay, Lerat, Lianet Noda-García, MacKerell, Mauricio Carrillo-Tripp, McCoy, Murshudov, Nester, Noda-Garcia, Ohno, Pal, Parish, Paul Gaytán, Perrakis, Piatigorsky, Sofía Medina-Ruíz, Sterner, Tokuriki, Tokuriki, Treangen, Vilmos Fülöp, Vriend, Wright, Xie, Xie   +54 more
core   +1 more source

Coordinated Slowing of Metabolism in Enteric Bacteria under Nitrogen Limitation: A Perspective [PDF]

arXiv, 2001
It is natural to ask how bacteria coordinate metabolism when depletion of an essential nutrient limits their growth, and they must slow their entire rate of biosynthesis. A major nutrient with a fluctuating abundance is nitrogen. The growth rate of enteric bacteria under nitrogen-limiting conditions is known to correlate with the internal concentration
arxiv  

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source