Results 101 to 110 of about 7,288,800 (308)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Nbr1 Is a Novel Inhibitor of Ligand-Mediated Receptor Tyrosine Kinase Degradation [PDF]

, 2010
endocytic trafficking and selective autophagy. However, the exact function of Nbr1 in these contexts has not been studied in detail. Here we investigated the role of Nbr1 in the trafficking of receptor tyrosine kinases (RTKs).
Auciello, Giulio, Dafforn, Tim R., Heath, John K, Mardakheh, Faraz K., Rappoport, Joshua Z.   +4 more
core   +2 more sources

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

The Role of Proteins in Biosilicification

Scientifica, 2012
Although the use of silicon dioxide (silica) as a constituent of living organisms is mainly restricted to diatoms and sponges, the ways in which this process is controlled by nature continue to inspire and fascinate.
Daniel Otzen
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Pregnancy-associated purpura fulminans (PF) Púrpura fulminans asociada al embarazo

Iatreia, 2005
<p>PF is a serious cutaneous purpuric disease, associated with an intravascular disseminated coagulation syndrome. Among its known causes, besides those of thrombophilia, are viral and bacterial infections, mostly Neisseria meningitidis.
Gisela de la Rosa Echavez, Marisol Bedoya A., Martín E. Vásquez, Nora E. Saldarriaga Cartagena, Alvaro H. Restrepo C., Jorge Hernando Donado Gómez, Carlos A. Cadavid Gutiérrez, Alvaro M. Quintero Ossa, Luis G. González P.   +8 more
doaj  

C-Reactive Protein-to-Albumin Ratio (CAR) and C-Reactive Protein-to-Lymphocyte Ratio (CLR) are Valuable Inflammatory Biomarker Combination for the Accurate Prediction of Periprosthetic Joint Infection

Infection and Drug Resistance, 2023
Weipeng Shi,1,2 Yaping Jiang,3 Hua Tian,4 Yingzhen Wang,1 Yingze Zhang,5 Tengbo Yu,1 Tao Li1 1Department of Orthopaedic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China; 2Medical Department of Qingdao University,
Shi W, Jiang Y, Tian H, Wang Y, Zhang Y, Yu T, Li T   +6 more
doaj  

Kinetics of the reduction of metalloproteins by chromous ion [PDF]

, 1972
The reduction of Cu(330) in Rhus vernicifera laccase by chromous ion is 30% faster than reduction of Cu(614) at room temperature [pH 4.8, µ = 0.1 (NaCl)], and two parallel first-order paths, attributed to heterogeneity of the protein, are observed at ...
Dawson, J. W., Gray, H. B., Holwerda, R. A., Westhead, E. W.   +3 more
core  

Blockade but not overexpression of the junctional adhesion molecule C influences virus-induced type 1 diabetes in mice [PDF]

, 2013
Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing beta-cells in the pancreas. Recruitment of inflammatory cells is prerequisite to beta-cell-injury.
Aurrand-Lions, Michel, Bayer, Monika, Christen, Selina, Christen, Urs, Coppieters, Ken, Herrath, Matthias G. von, Hintermann, Edith, Holdener, Martin, Imhof, Beat A., Pfeilschifter, Josef Martin (Prof. Dr.), Rose, Kerstin   +10 more
core   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source