Results 171 to 180 of about 25,791,466 (309)

Activated protein C modulates the proinflammatory activity of dendritic cells

, 2015
Takahiro Matsumoto,1,2* Yuki Matsushima,1* Masaaki Toda,1 Ziaurahman Roeen,1 Corina N D'Alessandro-Gabazza,1,5 Josephine A Hinneh,1 Etsuko Harada,1,3 Taro Yasuma,4 Yutaka Yano,4 Masahito Urawa,1,5 Tetsu Kobayashi,5 Osamu Taguchi,5 Esteban C Gabazza1 ...
Matsumoto T, Toda M, Kobayashi T, Yano Y, Taguchi O, Roeen Z, D’Alessandro-Gabazza CN, Hinneh JA, Urawa M, Yasuma T, Harada E, Gabazza EC, Matsushima Y   +12 more
core  

[Retracted] Activated protein C overexpression suppresses the pyroptosis of subarachnoid hemorrhage model cells by regulating the NLRP3 inflammasome pathway. [PDF]

Exp Ther Med
Yan A, Pan X, Wen X, Nie X, Li Y.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Activated Protein C and the Retina: From Physiology to Therapeutic Potential. [PDF]

Int J Mol Sci
Zahavi A, Levy-Mendelovich S, Griffin JH, Livnat T.   +3 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Sequential bilateral common carotid artery occlusion in protein C deficiency and patent foramen ovale: illustrative case. [PDF]

J Neurosurg Case Lessons
Kitamura Y, Nakatsukasa M.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Tail-anchored protein C-terminal domains stimulate ATP hydrolysis by the P5A-ATPase Spf1p. [PDF]

J Biol Chem
Cianci EO, Mazzitelli LR, Adamo HP.
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Protein C deficiency in a uremic patient: a rare case of multivessel thromboembolism and type 5 cardiorenal syndrome. [PDF]

BMC Cardiovasc Disord
Ying Q, Shen J, Yang X, Wu Y, Wu H, Shi X, Wu S, Zhao N, Wang M, Li X, Mao Y.   +10 more
europepmc   +1 more source