Results 1 to 10 of about 57,561 (211)

Monitoring of heparins in antithrombin-deficient patients

Thrombosis Research, 2019
INTRODUCTION Heparins exert their anticoagulant effect through activation of antithrombin. Whether antithrombin deficiency leads to clinically relevantly reduced anti-Xa activity of heparins is unknown.
Moniek P M de Maat, René Mulder, Karina Meijer   +2 more
exaly   +2 more sources

Mild antithrombin deficiency and risk of recurrent venous thromboembolism: results from the MEGA follow-up study

Journal of Thrombosis and Haemostasis, 2018
Willem M Lijfering, Saskia le Cessie, Suzanne C. Cannegieter   +2 more
exaly   +2 more sources

SERPINC1 gene mutations in antithrombin deficiency

British Journal of Haematology, 2017
René Mulder, Karina Meijer, James Andrew Huntington   +2 more
exaly   +2 more sources

Targeting of antithrombin in hemophilia A or B with investigational siRNA therapeutic fitusiran—Results of the phase 1 inhibitor cohort

Journal of Thrombosis and Haemostasis, 2021
Fitusiran, an investigational small interfering RNA therapy, reduces antithrombin production to rebalance hemostasis in people with hemophilia A or B, with or without inhibitors.
K. Pasi, T. Lissitchkov, V. Mamonov, T. Mant, M. Timofeeva, C. Bagot, P. Chowdary, P. Georgiev, L. Gercheva‐Kyuchukova, Kate Madigan, H. van Nguyen, Qi-Feng Yu, B. Mei, C. Benson, M. Ragni   +14 more
semanticscholar   +1 more source

Mild Antithrombin Deficiency and Risk of Recurrent Venous Thromboembolism: A Prospective Cohort Study

Circulation, 2014
Matteo Di Minno, Roberta Lupoli, Walter Ageno   +2 more
exaly   +2 more sources

Clinical controversies in anticoagulation monitoring and antithrombin supplementation for ECMO

Critical Care, 2020
During extracorporeal membrane oxygenation (ECMO), a delicate balance is required to titrate systemic anticoagulation to prevent thrombotic complications within the circuit and prevent bleeding in the patient.
Meghan M. Chlebowski, Sirine A. Baltagi, M. Carlson, J. Levy, P. Spinella   +4 more
semanticscholar   +1 more source

Anticoagulant and signaling functions of antithrombin

Journal of Thrombosis and Haemostasis, 2020
Antithrombin (AT) is a major plasma glycoprotein of the serpin superfamily that regulates the proteolytic activity of the procoagulant proteases of both intrinsic and extrinsic pathways.
A. Rezaie, H. Giri
semanticscholar   +1 more source

Hypoglycosylation is a common finding in antithrombin deficiency in the absence of a SERPINC1 gene defect

Journal of Thrombosis and Haemostasis, 2016
María Eugenia de la Morena Barrio, Irene Martínez-Martínez, Vicente Vicente   +2 more
exaly   +2 more sources

Recommendations for clinical laboratory testing for antithrombin deficiency; Communication from the SSC of the ISTH

Journal of Thrombosis and Haemostasis, 2020
Hereditary deficiency of antithrombin, a natural anticoagulant, causes a thrombophilia with a high risk for venous thromboembolism. Guidance for laboratory testing to diagnose antithrombin deficiency include the use of an activity assay for initial ...
E. V. Van Cott, C. Orlando, G. Moore, P. Cooper, P. Meijer, R. Marlar   +5 more
semanticscholar   +1 more source

Successful Antithrombin Administration in Andexanet Alfa-Associated Heparin Resistance.

Journal of Cardiothoracic and Vascular Anesthesia, 2020
The authors report the case of a patient treated with andexanet alfa who underwent CPB for emergency treatment of a tamponade. The occurrence of severe heparin resistance complicated the intraoperative course. Treatment included the immediate termination
Heleen J.C.L. Apostel, K. Winckers, E. Bidar, J. Schreiber   +3 more
semanticscholar   +1 more source