Results 11 to 20 of about 37,722 (251)

Quantification of antithrombin isoform proportions in plasma samples of healthy subjects, sepsis patients, and in antithrombin concentrates [PDF]

, 2002
Antithrombin (AT) circulates in plasma in two isoforms, AT-alpha (90-95%) and AT-beta (5-10%). AT isoform proportions were measured in plasma samples of 17 healthy subjects and 26 posttraumatic or postoperative septic patients, as well as in 4 ...
Inthorn, D., Donges, R., Muhlbayer, D., Hoffmann, J. N., Romisch, J., Jochum, M., Stauss, H.   +6 more
core   +1 more source

The Comparison of the Protective Effects of α- and β-Antithrombin against Vascular Endothelial Cell Damage Induced by Histone in Vitro

TH Open, 2017
Antithrombin is a promising option for the treatment of sepsis, and vascular endothelium is an important target for this fatal condition. Here, we aimed to evaluate the protective effects of different glycoforms of antithrombin on histone-induced ...
Toshiaki Iba, Tetsuya Sasaki, Kazutoshi Ohshima, Koichi Sato, Isao Nagaoka, Jecko Thachil   +5 more
doaj   +1 more source

Anti-Tumor Functions of Prelatent Antithrombin on Glioblastoma Multiforme Cells

Biomedicines, 2021
Antithrombin, the main physiological inhibitor of the coagulation cascade, exerts anti-tumor effects on glioblastoma multiforme cells. Antithrombin has different conformations: native, heparin-activated, prelatent, latent, and cleaved. The prelatent form
Julia Peñas-Martínez, Ginés Luengo-Gil, Salvador Espín, Nataliya Bohdan, Carmen Ortega-Sabater, Maria Carmen Ródenas, David Zaragoza-Huesca, María José López-Andreo, Carme Plasencia, Vicente Vicente, Alberto Carmona-Bayonas, Irene Martínez-Martínez   +11 more
doaj   +1 more source

The Influence of Calcium on the Binding of Antithrombin by Antithrombin Inhibitor.

Experimental Biology and Medicine, 1966
Summary and Conclusions1. The reaction between antithrombin and inhibitor has a quantitative requirement for calcium. 2. Calcium is not the inhibitor of antithrombin. 3. Calcium is not required for neutralization of thrombin by antithrombin.
H H, Henstell, M, Kligerman
openaire   +2 more sources

Antithrombin deficiency is associated with mortality and impaired organ function in septic pediatric patients: a retrospective study [PDF]

PeerJ, 2018
Background Sepsis remains a major problem in intensive care medicine. It is often accompanied by coagulopathies, leading to thrombotic occlusion of small vessels with subsequent organ damage and even fatal multi-organ failure.
Christian Niederwanger, Tobias Hell, Sophie Hofer, Christina Salvador, Miriam Michel, Bettina Schenk, Benedikt Treml, Mirjam Bachler   +7 more
doaj   +2 more sources

Antithrombin Deficiency: Frequency in Patients with Thrombosis and Thrombophilic Families

Acta Medica, 2023
Purpose: Antithrombin (AT) deficiency is a well-known inherited risk factor for venous thromboembolism (VTE). However, F V Leiden and F II20210a mutations have drawn much more attention in the recent years.
Maria Anna Pejková, Eva Ivanová, Petr Sadílek, Radovan Malý, Zuzana Thibaud, Petr Dulíček   +5 more
doaj   +1 more source

Antithrombotic Management during Percutaneous Mitral Valve Repair with the Mitraclip System in a Patient with Heparin-Induced Thrombocytopenia

TH Open, 2018
Interventional cardiology procedures require full anticoagulation to prevent thrombus formation on catheters and devices with potential development of embolic complications.
Francesco Saia, Elena Biagini, Alessandra Berardini, Matteo Chiarabelli, Emanuela Bertolino, Miriam Compagnone, Claudio Rapezzi   +6 more
doaj   +1 more source

Emicizumab, A Bispecific Antibody to Factors IX/IXa and X/Xa, Does Not Interfere with Antithrombin or TFPI Activity In Vitro

TH Open, 2018
Emicizumab is a humanized bispecific antibody that binds simultaneously to factor (F) IXa and FX replacing the cofactor function of FVIIIa. Because emicizumab recognizes FIX/FIXa and FX/FXa, a question may arise whether emicizumab competes with ...
Mariko Noguchi-Sasaki, Tetsuhiro Soeda, Atsunori Ueyama, Atsushi Muto, Michinori Hirata, Hidetomo Kitamura, Kaori Fujimoto-Ouchi, Yoshiki Kawabe, Keiji Nogami, Midori Shima, Takehisa Kitazawa   +10 more
doaj   +1 more source

Transient Hemi-Lower Limb Ischemia in the Newborn: Arterial Thrombosis or Persistent Sciatic Artery?

American Journal of Perinatology Reports, 2017
Neonatal thromboembolism occurs with various predispositions and triggers. Early diagnosis of the thrombosis is challenging and essential for the therapeutic interventions.
Makiko Kirino, Masayuki Ochiai, Masako Ichiyama, Hirosuke Inoue, Takeshi Kusuda, Tadamune Kinjo, Masataka Ishimura, Shouichi Ohga   +7 more
doaj   +1 more source

Sepsis-Associated DIC with Decreased Levels of Antithrombin and Fibrinogen is the Target for Combination Therapy with Thrombomodulin Alfa and Antithrombin

TH Open, 2023
Background Disseminated intravascular coagulation (DIC) is not a homogeneous condition, but rather includes heterogeneous conditions, and its pathophysiology and outcome vary considerably depending on the background.
Hideo Wada, Kazuo Kawasugi, Goichi Honda, Noriaki Kawano, Toshimasa Uchiyama, Seiji Madoiwa, Naoki Takezako, Kei Suzuki, Yoshinobu Seki, Takayuki Ikezoe, Toshiaki Iba, Kohji Okamoto   +11 more
doaj   +1 more source