Results 11 to 20 of about 7,288,800 (308)
Enzymatic C‐to‐C Protein Ligation [PDF]
Angewandte Chemie International Edition, 2022 AbstractTranspeptidase‐catalyzed protein and peptide modifications have been widely utilized for generating conjugates of interest for biological investigation or therapeutic applications. However, all known transpeptidases are constrained to ligating in the N‐to‐C orientation, limiting the scope of attainable products.
Fabian B. H. Rehm +4 more
openaire +3 more sources
Archives of Pathology & Laboratory Medicine, 2019 Protein C (PC) deficiency is a heritable or acquired risk factor for thrombophilia, with presentations varying from asymptomatic to venous thromboembolism to neonatal purpura fulminans, a life-threatening disorder. Hereditary PC deficiency is caused by mutation in the PC (PROC) gene located on chromosome 2q14.3.
Peyman, Dinarvand, Karen A, Moser
openaire +2 more sources
Journal of Biological Chemistry, 2004 C-reactive protein (CRP) is a phylogenetically highly conserved plasma protein, with homologs in vertebrates and many invertebrates, that participates in the systemic response to inflammation. Its plasma concentration increases during inflammatory states, a characteristic that has long been employed for clinical purposes.
Steven, Black +2 more
openaire +2 more sources
Indian Journal of Hematology and Blood Transfusion, 2013 This report describes a 4 year old female child who presented with fever, pain and swelling of left leg following a trivial trauma. She was diagnosed as a case of deep vein thrombosis and subsequently found to be due to protein C deficiency.
Arun K, De +3 more
openaire +2 more sources
Methionine synthase reductase A66G polymorphism and ischemic stroke in younger patients
Неврология, нейропсихиатрия, психосоматика, 2021 In the past decade, stroke incidence in younger adults increased. Methionine synthase reductase (MTRR) A66G polymorphism is one of the risk factors for ischemic stroke (IS).
O. V. Tsyganenko +2 more
doaj +1 more source
Electron Transfer Precedes ATP Hydrolysis during Nitrogenase Catalysis [PDF]
, 2013 The biological reduction of N2 to NH3 catalyzed by Mo-dependent nitrogenase requires at least eight rounds of a complex cycle of events associated with ATP-driven electron transfer (ET) from the Fe protein to the catalytic MoFe protein, with each ET ...
Antony, Edwin +7 more
core +2 more sources
Combined Thrombophilia in a Young Male Presenting as Life Threatening Pulmonary Embolism [PDF]
Journal of Clinical and Diagnostic Research, 2017 Combined hereditary thrombophilia is an uncommon entity associated with higher risk of early onset thrombosis. We report a case of 39-year-old male with combined deficiency of natural anticoagulants (protein C, S and anti thrombin) along with hyper ...
Akshyaya Pradhan +4 more
doaj +1 more source
An eIF4E-binding protein regulates katanin protein levels in C. elegans embryos. [PDF]
, 2009 In Caenorhabditis elegans, the MEI-1-katanin microtubule-severing complex is required for meiosis, but must be down-regulated during the transition to embryogenesis to prevent defects in mitosis.
DeBella, Leah +4 more
core +2 more sources
Requirement of the FATC domain of protein kinase Tel1 for localization to DNA ends and target protein recognition [PDF]
, 2015 Two large phosphatidylinositol 3-kinase-related protein kinases (PIKKs), ATM and ATR, play a central role in the DNA damage response pathway. PIKKs contain a highly conserved extreme C-terminus called the FRAP-ATM-TRRAP-C-terminal (FATC) domain.
Ghosh, A. +5 more
core +1 more source
Structure of HrcQ(B)-C, a conserved component of the bacterial type III secretion systems [PDF]
, 2003 Type III secretion systems enable plant and animal bacterial pathogens to deliver virulence proteins into the cytosol of eukaryotic host cells, causing a broad spectrum of diseases including bacteremia, septicemia, typhoid fever, and bubonic plague in ...
A. P. Tampakaki +33 more
core +2 more sources