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Current Opinion in Hematology, 2022
Purpose of review To provide an overview of the state-of-the-art in protein C (PC) pathway research. Recent findings The PC pathway is crucial for maintaining hemostasis to prevent venous thromboembolism.
Gemma, Leon +2 more
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Purpose of review To provide an overview of the state-of-the-art in protein C (PC) pathway research. Recent findings The PC pathway is crucial for maintaining hemostasis to prevent venous thromboembolism.
Gemma, Leon +2 more
openaire +2 more sources
Journal of Thrombosis and Haemostasis, 2007
Protein C is a vitamin K-dependent plasma protein zymogen whose genetic mild or severe deficiencies are linked with risk for venous thrombosis or neonatal purpura fulminans, respectively. Studies over past decades showed that activated protein C (APC) inactivates factors (F) Va and VIIIa to down-regulate thrombin generation.
J H, Griffin +3 more
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Protein C is a vitamin K-dependent plasma protein zymogen whose genetic mild or severe deficiencies are linked with risk for venous thrombosis or neonatal purpura fulminans, respectively. Studies over past decades showed that activated protein C (APC) inactivates factors (F) Va and VIIIa to down-regulate thrombin generation.
J H, Griffin +3 more
openaire +2 more sources
2013
Protein C (PC) is a 62-kDa vitamin K-dependent plasma zymogen which, after activation to serine protease, plays an important role in the physiologic regulation of blood coagulation. Given that PC is one of the major naturally occurring inhibitors of coagulation, acquired or hereditary deficiencies of this protein result in excessive thrombin generation.
Mirta, Hepner, Vasiliki, Karlaftis
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Protein C (PC) is a 62-kDa vitamin K-dependent plasma zymogen which, after activation to serine protease, plays an important role in the physiologic regulation of blood coagulation. Given that PC is one of the major naturally occurring inhibitors of coagulation, acquired or hereditary deficiencies of this protein result in excessive thrombin generation.
Mirta, Hepner, Vasiliki, Karlaftis
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Seminars in Thrombosis and Hemostasis, 2011
Protein C inhibitor (PCI) is a serine protease inhibitor and was originally identified as an inhibitor of activated protein C (APC). However, PCI is not specific for APC and also inhibits several proteases involved in coagulation, fibrinolysis, cancer, wound healing, and fertility.
Meijers, Joost C. M., Herwald, Heiko
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Protein C inhibitor (PCI) is a serine protease inhibitor and was originally identified as an inhibitor of activated protein C (APC). However, PCI is not specific for APC and also inhibits several proteases involved in coagulation, fibrinolysis, cancer, wound healing, and fertility.
Meijers, Joost C. M., Herwald, Heiko
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Pharmacology & Therapeutics, 1991
Based on the molecular structure of the individual members of the protein kinase C family, general properties and the mode of activation of this enzyme family are discussed. Examples are presented of how the investigation of protein kinase C function in vivo has been approached at the molecular level.
S, Stabel, P J, Parker
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Based on the molecular structure of the individual members of the protein kinase C family, general properties and the mode of activation of this enzyme family are discussed. Examples are presented of how the investigation of protein kinase C function in vivo has been approached at the molecular level.
S, Stabel, P J, Parker
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Journal of Cellular Physiology, 1986
The combined application of protein structural techniques, immunochemistry, and molecular biology has permitted an analysis of the differential expression of the genes for the three related protein kinases, C-alpha, -beta, and gamma. The evidence now suggests that the type of protein kinase C in a cell may govern the nature and mechanisms of functional
P J, Parker, A, Ullrich
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The combined application of protein structural techniques, immunochemistry, and molecular biology has permitted an analysis of the differential expression of the genes for the three related protein kinases, C-alpha, -beta, and gamma. The evidence now suggests that the type of protein kinase C in a cell may govern the nature and mechanisms of functional
P J, Parker, A, Ullrich
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Homozygous protein C deficiency—management with protein C concentrate
European Journal of Pediatrics, 1995Two unrelated female infants with homozygous protein C (Pr C) deficiency are reported. Both are of U.K. Pakistani origin and in each case the parents are consanguinous. A previous sibling had died in each family. Both sets of parents were shown to be carriers. The concentration of Pr C in both infants was low at birth.
V, Baliga +5 more
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Southern Medical Journal, 1987
Severe homozygous protein C deficiency is a rare but serious problem in the newborn, with a clinical presentation of purpura fulminans. We have presented such a case in an 1,870 gm female neonate. Salient clinical findings in this case include DIC associated with extensive ecchymosis and subsequent gangrene of the skin, thrombotic complications that ...
E S, Rappaport +6 more
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Severe homozygous protein C deficiency is a rare but serious problem in the newborn, with a clinical presentation of purpura fulminans. We have presented such a case in an 1,870 gm female neonate. Salient clinical findings in this case include DIC associated with extensive ecchymosis and subsequent gangrene of the skin, thrombotic complications that ...
E S, Rappaport +6 more
openaire +2 more sources
A radioimmunoassay for protein C
Thrombosis Research, 1985A simple and dependable radioimmunoassay has been devised to measure protein C in human plasma. From a rabbit antiserum against human protein C, the antibodies recognizing the activation peptide region (residues 1-15) in the heavy chain of protein C were affinity purified for use in the radioimmunoassay.
K, Ikeda, J, Stenflo
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