Results 241 to 250 of about 7,288,800 (308)

Release of Cardiac Myosin-binding Protein C Compared With Cardiac Troponin After Brief Ischemia in Humans. [PDF]

CJC Open
Alaour B, Hasselbalch RB, Arnadottir A, Kaier TE, McGrath S, Haahr-Pedersen SA, Bundgaard H, Marber M, Iversen KK.   +8 more
europepmc   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Parenchymal and inflammatory responses to ozone exposure in the aging healthy and surfactant protein C mutant lung. [PDF]

Am J Physiol Lung Cell Mol Physiol
Cheminant JR, Deering-Rice CE, Massa CB, Adhikari U, Noll J, Reilly CA, Venosa A.   +6 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Outer membrane protein C (OMPC) epitope of <i>Shigella flexneri</i> 3a as a potential marker of primary immunodeficiencies (PID) and isolated anti-OmpC antibodies as a tool for immunoglobulin replacement therapy. [PDF]

Front Immunol
Naporowski P, Witkowska D, Rybka J, Pawlak E, Lewandowicz-Uszyńska A, Masłowska E, Gamian A.   +6 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Challenges in managing severe homozygous protein c deficiency: a case report. [PDF]

Blood Coagul Fibrinolysis
Almatter E, Alsharidah S, Bourhama M, Bourusly M, Obaid MA.   +4 more
europepmc   +1 more source

In vivo neuroprotection in ischemic stroke by activated protein C requires β-arrestin 2. [PDF]

Blood Vessel Thromb Hemost
Xiang B, Wang Y, Rust R, Kisler K, Mack WJ, Fernández JA, Zlokovic BV, Griffin JH.   +7 more
europepmc   +1 more source

Protein C deficiency with recurrent systemic thrombosis associated with compound heterozygous PROC missense variants. [PDF]

Am Heart J Plus
Shiba M, Higo S, Morishita Y, Ichibori Y, Kin Y, Sakata Y, Higuchi Y.   +6 more
europepmc   +1 more source

Validation for the function of protein C in mouse models. [PDF]

PeerJ
Liu Y, Cai M, Chen Y, Wu G, Li S, Chen Z.   +5 more
europepmc   +1 more source