Results 161 to 170 of about 1,141,379 (303)

Molecular basis of inherited protein C deficiency results from genetic variations in the signal peptide and propeptide regions. [PDF]

J Thromb Haemost, 2023
Cao Q, Hao Z, Li C, Chen X, Gao M, Jiang N, Liu H, Shen Y, Yang H, Zhang S, Yang A, Li W, Tie JK, Shen G.   +13 more
europepmc   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Idiopathic pulmonary hemosiderosis and stroke secondary to protein C deficiency in a child with Down syndrome: a case report. [PDF]

J Med Case Rep, 2023
Ajmi H, Bouafsoun C, Arifa N, Chemli J, Abroug S.   +4 more
europepmc   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Pulmonary Embolism Presenting as Recurrent Syncope and Visual Disturbances in a Patient With Protein C Deficiency: An Atypical Emergency Department Presentation. [PDF]

Cureus
Rana T, Kaeley N, Tejpal P, Yadav S, Mudi D.   +4 more
europepmc   +1 more source

Hereditary protein C deficiency with portal vein thrombosis in a Chinese male: A case report. [PDF]

Exp Ther Med, 2022
Zou C, Li T, Long L, Liu L, Zhu J.
europepmc   +1 more source

Protein C Deficient Mice.

Japanese Journal of Thrombosis and Hemostasis, 1999
Katsuro SHIMOSE, Takayoshi HAMAMOTO, Jun MIZUGUCHI   +2 more
openaire   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Multisystem embolism in hereditary protein C deficiency with patent foramen ovale: a case report. [PDF]

Front Cardiovasc Med
Chen L, Guan J, Ni Y.
europepmc   +1 more source

A case of venous thromboembolism caused by protein C deficiency due to a novel gene mutation. [PDF]

J Cardiol Cases, 2022
Noiri JI, Matsuzoe H, Nagaya S, Nishio R, Matsumoto D, Takaishi H, Morishita E.   +6 more
europepmc   +1 more source