Results 171 to 180 of about 1,141,379 (303)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Purpura Fulminans Due to Escherichia coli Septicemia in Relapsed Acute Myeloid Leukemia: An Unusual Case of Protein C Deficiency and Disseminated Intravascular Coagulation. [PDF]

Cureus
Zieneldien T, Ma S, Singh K, Singh A, Kim J, Velez A, Greene J.   +6 more
europepmc   +1 more source

[Clinical characteristics and gene mutation analysis of two families with hereditary protein C deficiency]. [PDF]

Zhonghua Xue Ye Xue Za Zhi, 2023
Zeng ML, Yang LL, Zou AQ, Chen Y, Jia KQ, Wang MS, Jin YH.   +6 more
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Liver Transplantation as a Definitive Treatment for Homozygous Protein C Deficiency. [PDF]

Cureus
Syed Iqbaluddin J, Asif Amin S, Fawzy Nazir Abouelkhel H, Shaji Mathew J, Sen G, Saif R.   +5 more
europepmc   +1 more source

Hepatic Necrosis Mimicking Infiltrative Masses in Acute Budd-Chiari Syndrome With Hereditary Protein C Deficiency. [PDF]

ACG Case Rep J, 2022
Ananchuensook P, Karuehardsuwan J, Sanpawat A, Wisedopas N, Treeprasertsuk S, Komolmit P, Thanapirom K.   +6 more
europepmc   +1 more source

Protein C deficiency

, 2018
Yuranga Weerakkody, Abenezer Assefa, Hamish Smith   +2 more
openaire   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

The lost chILD: a case report of delayed diagnosis of surfactant protein C deficiency in a 15-year-old African male. [PDF]

Ital J Pediatr
Faelli N, Chironi F, Andrenacci B, Patria MF, Ferrero S, Borzani I, Pucci C, Civeriati D, Lelii M, Madini B, Rocchi A, Daccò V.   +11 more
europepmc   +1 more source

Protein C deficiency: Report of a challenging case with recurrent multiorgan thrombosis. [PDF]

Int J Surg Case Rep, 2021
Afghani R, Gharib H, Kor F, Kharazm P.
europepmc   +1 more source