Results 11 to 20 of about 2,538,848 (322)

The Functional Meaning of 5'UTR in Protein-Coding Genes. [PDF]

Int J Mol Sci, 2023
As it is well known, messenger RNA has many regulatory regions along its sequence length. One of them is the 5′ untranslated region (5’UTR), which itself contains many regulatory elements such as upstream ORFs (uORFs), internal ribosome entry sites ...
Ryczek N, Łyś A, Makałowska I.
europepmc   +2 more sources

Genome-wide annotation of protein-coding genes in pig. [PDF]

BMC Biol, 2022
There is a need for functional genome-wide annotation of the protein-coding genes to get a deeper understanding of mammalian biology. Here, a new annotation strategy is introduced based on dimensionality reduction and density-based clustering of whole ...
Karlsson M, Sjöstedt E, Oksvold P, Sivertsson Å, Huang J, Álvez MB, Arif M, Li X, Lin L, Yu J, Ma T, Xu F, Han P, Jiang H, Mardinoglu A, Zhang C, von Feilitzen K, Xu X, Wang J, Yang H, Bolund L, Zhong W, Fagerberg L, Lindskog C, Pontén F, Mulder J, Luo Y, Uhlen M.   +27 more
europepmc   +2 more sources

Fact or fiction: updates on how protein-coding genes might emerge de novo from previously non-coding DNA [version 1; referees: 3 approved]

F1000Research, 2017
Over the last few years, there has been an increasing amount of evidence for the de novo emergence of protein-coding genes, i.e. out of non-coding DNA. Here, we review the current literature and summarize the state of the field.
Jonathan F Schmitz, Erich Bornberg-Bauer
doaj   +2 more sources

Housekeeping protein-coding genes interrogated with tissue and individual variations [PDF]

Scientific Reports
Housekeeping protein-coding genes are stably expressed genes in cells and tissues that are thought to be engaged in fundamental cellular biological functions.
Kuo-Feng Tung, Chao-Yu Pan, Wen-chang Lin   +2 more
doaj   +2 more sources

A subset of conserved mammalian long non-coding RNAs are fossils of ancestral protein-coding genes

Genome Biology, 2017
Background Only a small portion of human long non-coding RNAs (lncRNAs) appear to be conserved outside of mammals, but the events underlying the birth of new lncRNAs in mammals remain largely unknown.
Hadas Hezroni, Rotem Ben-Tov Perry, Zohar Meir, Gali Housman, Yoav Lubelsky, Igor Ulitsky   +5 more
doaj   +2 more sources

TAF2, within the TFIID complex, regulates the expression of a subset of protein-coding genes [PDF]

Cell Death Discovery
TFIID, one of the general transcription factor (GTF), regulates transcriptional initiation of protein-coding genes through direct binding to promoter elements and subsequent recruitment of other GTFs and RNA polymerase II. Although generally required for
I-Hsin Cheng, Wen-Chieh Pi, Chung-Hao Hsu, Yiran Guo, Jun-Lin Lai, Gang G. Wang, Bon-chu Chung, Robert G. Roeder, Wei-Yi Chen   +8 more
doaj   +2 more sources

Analysis of protein-coding genetic variation in 60,706 humans

Nature, 2015
Large-scale reference data sets of human genetic variation are critical for the medical and functional interpretation of DNA sequence changes. Here we describe the aggregation and analysis of high-quality exome (protein-coding region) DNA sequence data ...
James Y. Zou
semanticscholar   +1 more source

Top-ranked expressed gene transcripts of human protein-coding genes investigated with GTEx dataset

Scientific Reports, 2020
With considerable accumulation of RNA-Seq transcriptome data, we have extended our understanding about protein-coding gene transcript compositions. However, alternatively compounded patterns of human protein-coding gene transcripts would complicate gene ...
Kuo-Feng Tung, Chao-Yu Pan, Chao-Hsin Chen, Wen-chang Lin   +3 more
semanticscholar   +1 more source

Variation across 141,456 human exomes and genomes reveals the spectrum of loss-of-function intolerance across human protein-coding genes

bioRxiv, 2019
Genetic variants that inactivate protein-coding genes are a powerful source of information about the phenotypic consequences of gene disruption: genes critical for an organism’s function will be depleted for such variants in natural populations, while ...
K. Karczewski, L. Francioli, G. Tiao, Beryl B. Cummings, Jessica Alföldi, Qingbo S. Wang, Ryan L. Collins, Kristen M. Laricchia, A. Ganna, Daniel P Birnbaum, L. Gauthier, H. Brand, M. Solomonson, N. Watts, Daniel Rhodes, M. Singer-Berk, Eleanor G. Seaby, J. Kosmicki, R. Walters, K. Tashman, Y. Farjoun, E. Banks, T. Poterba, Arcturus Wang, C. Seed, N. Whiffin, Jessica X. Chong, K. Samocha, E. Pierce-Hoffman, Zachary Zappala, A. O’Donnell-Luria, E. Minikel, B. Weisburd, M. Lek, J. Ware, C. Vittal, Irina M. Armean, Louis Bergelson, K. Cibulskis, K. Connolly, Miguel Covarrubias, S. Donnelly, S. Ferriera, S. Gabriel, Jeff Gentry, N. Gupta, Thibault Jeandet, D. Kaplan, Christopher Llanwarne, Ruchi Munshi, Sam Novod, Nikelle Petrillo, David Roazen, Valentín Ruano-Rubio, A. Saltzman, M. Schleicher, José Soto, Kathleen M. Tibbetts, C. Tolonen, Gordon Wade, M. Talkowski, B. Neale, M. Daly, D. MacArthur   +63 more
semanticscholar   +1 more source

Improved annotation of protein-coding genes boundaries in metazoan mitochondrial genomes

Nucleic Acids Research, 2019
With the rapid increase of sequenced metazoan mitochondrial genomes, a detailed manual annotation is becoming more and more infeasible. While it is easy to identify the approximate location of protein-coding genes within mitogenomes, the peculiar ...
A. Donath, Frank Jühling, Marwa Al-Arab, S. Bernhart, Franziska Reinhardt, P. Stadler, M. Middendorf, Matthias Bernt   +7 more
semanticscholar   +1 more source