Results 61 to 70 of about 2,538,848 (322)

Evolutionary hallmarks of the human proteome: chasing the age and coregulation of protein-coding genes [PDF]

, 2016
Background The development of large-scale technologies for quantitative transcriptomics has enabled comprehensive analysis of the gene expression profiles in complete genomes.
Francisco José Campos-Laborie, Javier De Las Rivas, José Miguel Ortega, Katia de Paiva Lopes, Ricardo Assunção Vialle   +4 more
core   +5 more sources

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

First mitogenome for the subfamily Miltogramminae (Diptera: Sarcophagidae) and its phylogenetic implications

European Journal of Entomology, 2017
The mitochondrial genome of Mesomelena mesomelaena (Loew, 1848) is the first to be sequenced in the flesh fly subfamily Miltogramminae (Diptera: Sarcophagidae).
Liping YAN, Ming ZHANG, Yunyun GAO, Thomas PAPE, Dong ZHANG   +4 more
doaj   +1 more source

Automated DNA Motif Discovery [PDF]

, 2010
Ensembl's human non-coding and protein coding genes are used to automatically find DNA pattern motifs. The Backus-Naur form (BNF) grammar for regular expressions (RE) is used by genetic programming to ensure the generated strings are legal.
Graillet, Olivia Sanchez, Harrison, A. P., Langdon, W. B.   +2 more
core   +2 more sources

Draft Genome Sequence of Photorhabdus luminescens Strain BA1, an Entomopathogenic Bacterium Isolated from Nematodes Found in Egypt [PDF]

, 2014
Photorhabdus luminescens strain BA1 is an entomopathogenic bacterium that forms a symbiotic association with Heterorhabditis nematodes. We report here a 5.0-Mbp draft genome sequence for P.
Abebe-Akele, Feseha, AbouZaied, Mohamed A., Badr, Usama M., Ghazal, Shimaa M., Hurst, Sheldon G., IV, Hussein, Mona A., Khalil, Kamal M., Morris, Krystalynne, Thomas, W. Kelley, Tisa, Louis S.   +9 more
core   +2 more sources

Defining Essentiality Score of Protein-Coding Genes and Long Noncoding RNAs

Frontiers in Genetics, 2018
Measuring the essentiality of genes is critically important in biology and medicine. Here we proposed a computational method, GIC (Gene Importance Calculator), which can efficiently predict the essentiality of both protein-coding genes and long noncoding
P. Zeng, Ji Chen, Yuhong Meng, Yuan Zhou, Jichun Yang, Qinghua Cui   +5 more
semanticscholar   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

Complete sequence of mitochondrial DNA of Gracilaria tenuistipitata (Rhodophyta)

Mitochondrial DNA. Part B. Resources, 2018
We sequenced and analysed the complete mitogenome of Gracilaria tenuistipitata. The complete G. tenuistipitata mitogenome is 25,819 bp long, containing 50 genes, including 24 protein-coding genes, one intron, two rRNA genes, 23 tRNA genes, and one ...
Na Liu, Yue Li, Cui Liu, Tao Liu, Weizhou Chen   +4 more
doaj   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

CHESS 3: an improved, comprehensive catalog of human genes and transcripts based on large-scale expression data, phylogenetic analysis, and protein structure

Genome Biology, 2023
CHESS 3 represents an improved human gene catalog based on nearly 10,000 RNA-seq experiments across 54 body sites. It significantly improves current genome annotation by integrating the latest reference data and algorithms, machine learning techniques ...
Ales Varabyou, Markus J. Sommer, Beril Erdogdu, Ida Shinder, Ilia Minkin, Kuan-Hao Chao, Sukhwan Park, Jakob Heinz, Christopher Pockrandt, Alaina Shumate, Natalia Rincon, Daniela Puiu, Martin Steinegger, Steven L. Salzberg, Mihaela Pertea   +14 more
doaj   +1 more source