Results 91 to 100 of about 6,634,608 (387)

Protein Allostery and Conformational Dynamics [PDF]

Chemical Reviews, 2016
The functions of many proteins are regulated through allostery, whereby effector binding at a distal site changes the functional activity (e.g., substrate binding affinity or catalytic efficiency) at the active site. Most allosteric studies have focused on thermodynamic properties, in particular, substrate binding affinity. Changes in substrate binding
Jingjing, Guo, Huan-Xiang, Zhou
openaire   +2 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

In-cell single-molecule FRET measurement of cytosolic RAF proteins to investigate the structural states and kinetics among them

Frontiers in Molecular Biosciences
The structure of a protein is closely linked to its function. Many proteins undergo conformational changes while working in living cells. Consequently, proteins in various structural states coexist in the native cellular environment.
Kenji Okamoto, Yasushi Sako
doaj   +1 more source

Role of Pre-molten Globule Structure in Protein Amyloid Fibril Formation [PDF]

Avicenna Journal of Medical Biochemistry, 2019
The conversion of a protein from its native conformation to the pathogenic form is a critical event in the pathogenesis of several neurodegenerative disorders such as Alzheimer’s (AD), Parkinson’s, and Huntington’s diseases, along with type II diabetic ...
Ali Es-haghi, Mahsa Jahedi Moghaddam, Koorosh Shahpasand   +2 more
doaj   +1 more source

alpha -Lactalbumin (LA) Stimulates Milk beta-1,4-Galactosyltransferase I (beta 4Gal-T1) to Transfer Glucose from UDP-glucose to N-Acetylglucosamine: CRYSTAL STRUCTURE OF beta 4Gal-T1·LA COMPLEX WITH UDP-Glc* [PDF]

, 2001
beta-1,4-Galactosyltransferase 1 (Gal-T1) transfers galactose (Gal) from UDP-Gal to N-acetylglucosamine (GlcNAc), which constitutes its normal galactosyltransferase (Gal-T) activity.
Qasba, Pradman K., Ramakrishnan, Boopathy, Shah, Premal S.   +2 more
core  

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Spatiotemporal evaluation of antithrombotic performance for biomaterials through monitoring β-sheet conformation changes at the blood interface

Bioactive Materials
Thrombosis remains a critical challenge for blood-contacting medical devices, often resulting in device failure and potentially fatal complications.
Hui Zhou, Yizhou Xu, Shuxiang Zhang, Jierui Fan, Qiang Wei, Changsheng Zhao   +5 more
doaj   +1 more source

Effect of bamboo shoot dietary fiber on gel quality, thermal stability and secondary structure changes of pork salt-soluble proteins

CyTA - Journal of Food, 2019
The effect of bamboo shoot dietary fibre (BSDF) (0%-4%) on the gel quality, protein thermal stability and secondary structure of pork salt-soluble proteins (SSP) was investigated.
Ke Li, Jun-Ya Liu, Yan-Hong Bai, Ying-Ying Zhao, Yan-Yan Zhang, Jun-Guang Li, Hua Zhang, Diao-Bo Zhao   +7 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Insulin and Insulin Receptor Variants: Structural and Functional Insights into Insulin Resistance

Korean Journal of Clinical Laboratory Science
Insulin resistance (IR), a defining pathological feature of type 2 diabetes mellitus, results from impaired signaling through the insulin receptor (INSR).
Hyun Ho SUNG, Ho-Keun CHOI, Kyung Bae LEE   +2 more
doaj   +1 more source