Results 111 to 120 of about 6,498,873 (334)

Conformation of Proteins and Polypeptides

, 1965
Theodore T. Herskovits, Linda Mescanti
openalex   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Determination of protein conformation and orientation at buried solid/liquid interfaces. [PDF]

Chem Sci, 2023
Guo W, Lu T, Crisci R, Nagao S, Wei T, Chen Z.   +5 more
europepmc   +1 more source

On the Conformational Stability of Globular Proteins

, 1965
Peter H. von Hippel, Kwok-Ying Wong
openalex   +1 more source

Alteration of 5S RNA conformation by ribosomal proteins L18 and L25 [PDF]

, 1977
David G. Bear, Thomas Schleich, Harry F. Noller, Roger A. Garrett   +3 more
openalex   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Effect of cavitation jet technology on instant solubility characteristics of soymilk flour: Based on the change of protein conformation in soymilk. [PDF]

Ultrason Sonochem, 2023
Gong Q, Liu C, Tian Y, Zheng Y, Wei L, Cheng T, Wang Z, Guo Z, Zhou L.   +8 more
europepmc   +1 more source

Stereochemical Criteria for Polypeptide and Protein Chain Conformations

, 1966
G. N. Ramachandran, C. M. Venkatachalam, S. Krimm   +2 more
openalex   +1 more source

Conformational alteration of protein synthesis elongation factor EF-Tu by EF-Ts and by kirromycin. [PDF]

, 1977
Thomas Blumenthal, J Douglass, Denise M. Smith   +2 more
openalex   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source