Results 151 to 160 of about 6,498,873 (334)

Cross-linking studies on the conformation and dimerization of myelin basic protein in solution.

, 1978
E.E. Golds, Pascal Falter‐Braun
openalex   +1 more source

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source

Codon usage bias regulates gene expression and protein conformation in yeast expression system P. pastoris. [PDF]

Microb Cell Fact, 2021
Xu Y, Liu K, Han Y, Xing Y, Zhang Y, Yang Q, Zhou M.   +6 more
europepmc   +1 more source

Effects of Cation Binding on the Conformation of Calsequestrin and the High Affinity Calcium-binding Protein of Sarcoplasmic Reticulum

, 1974
Thomas J. Ostwald, David H. MacLennan, Keith J. Dorrington   +2 more
openalex   +1 more source

The Role of Ribosomal Conformation in Protein Biosynthesis [PDF]

, 1972
Michael I. Sherman
openalex   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Association between Predicted Effects of TP53 Missense Variants on Protein Conformation and Their Phenotypic Presentation as Li-Fraumeni Syndrome or Hereditary Breast Cancer. [PDF]

Int J Mol Sci, 2021
Liu Y, Axell O, van Leeuwen T, Konrat R, Kharaziha P, Larsson C, Wright APH, Bajalica-Lagercrantz S.   +7 more
europepmc   +1 more source

Studies of the molecular conformations in proteins by 2H and 13C n.m.r. spectroscopy [PDF]

, 1974
Kurt Wüthrich
openalex   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Allosteric behavior irrespective of conformational change of enzyme protein. Sigmoidal concentration dependence of rate of action of saccharifying α‐amylase on maltose [PDF]

, 1976
Haruko Fujimori, Masatake Ohnishi, Mitsuaki Sakoda, Ryuichi Matsuno, Keitaro Hiromi   +4 more
openalex   +1 more source