Results 151 to 160 of about 6,540,405 (386)
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Protein conformation and disease.
Veterinary research, 1996 In a number of neurodegenerative diseases, a change in the conformation of specific proteins occurs which is considered to be related to the development of the disease process. In general, a change in the protein conformation from a predominantly alpha-helical to a predominantly beta-sheet structure, due to genetic or environmental factors, leads to ...
openaire +2 more sources
Conformational Filtering in Polypeptides and Proteins
Journal of Molecular Biology, 1993 We present a method for assigning an ensemble of conformational states to each amino acid residue of a sequence. The states are defined as regions in the (phi, psi) map. The procedure is based on the use of conformational filters. In each filter we use a different set of approximations to estimate the probability of conformational states, and retain ...
openaire +3 more sources
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Assessments of Variational Autoencoder in Protein Conformation Exploration. [PDF]
J Comput Biophys Chem, 2023 Xiao S, Song Z, Tian H, Tao P.
europepmc +1 more source
Alteration of 5S RNA conformation by ribosomal proteins L18 and L25 [PDF]
, 1977 David G. Bear +3 more
openalex +1 more source
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
FoodsThe aim of this work was to systematically evaluate the effects of Lion’s Mane Mushroom powder (LMM, 0–40%) on the physicochemical properties, structural characteristics, and flavor profile of soy protein isolate-based high-moisture meat analogues (HMMAs)
Yang Gao +5 more
doaj +1 more source
Studies of the molecular conformations in proteins by 2H and 13C n.m.r. spectroscopy [PDF]
, 1974 Kurt Wüthrich
openalex +1 more source
Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner +6 more
wiley +1 more source