Results 11 to 20 of about 6,585,847 (336)

N-Glycosylation as a Modulator of Protein Conformation and Assembly in Disease [PDF]

Biomolecules
Glycosylation, a prevalent post-translational modification, plays a pivotal role in regulating intricate cellular processes by covalently attaching glycans to macromolecules.
Pasala C, Sharma S, Roychowdhury T, Moroni E, Colombo G, Chiosis G.   +5 more
semanticscholar   +2 more sources

Characterizing Post-Translational Modifications and Their Effects on Protein Conformation Using NMR Spectroscopy. [PDF]

Biochemistry, 2019
The diversity of the cellular proteome substantially exceeds the number of genes coded by the DNA of an organism because one or more residues in a majority of eukaryotic proteins are post-translationally modified (PTM) by the covalent conjugation of ...
Ajith Kumar, Vaishali Narayanan, A. Sekhar   +2 more
semanticscholar   +2 more sources

Predicting Binding Free Energies of PDE2 Inhibitors. The Difficulties of Protein Conformation [PDF]

Sci Rep, 2018
A congeneric series of 21 phosphodiesterase 2 (PDE2) inhibitors are reported. Crystal structures show how the molecules can occupy a ‘top-pocket’ of the active site.
L. Pérez-Benito, Henrik Keränen, H. V. van Vlijmen, G. Tresadern   +3 more
semanticscholar   +2 more sources

Effects of Fluorophore Attachment on Protein Conformation and Dynamics Studied by spFRET and NMR Spectroscopy. [PDF]

Chemistry, 2017
Carolina Sánchez-Rico, L. Voith von Voithenberg, Lisa Warner, D. Lamb, M. Sattler   +4 more
semanticscholar   +2 more sources

Translation from the Ribosome to the Clinic: Implication in Neurological Disorders and New Perspectives from Recent Advances

Biomolecules, 2019
De novo protein synthesis by the ribosome and its multitude of co-factors must occur in a tightly regulated manner to ensure that the correct proteins are produced accurately at the right time and, in some cases, also in the proper location.
Kelvin K. Hui, Yi-Kai Chen, Ryo Endo, Motomasa Tanaka   +3 more
doaj   +1 more source

Mechano-transduction: from molecules to tissues. [PDF]

, 2014
External forces play complex roles in cell organization, fate, and homeostasis. Changes in these forces, or how cells respond to them, can result in abnormal embryonic development and diseases in adults.
Dunn, Alexander R, Nelson, W James, Pruitt, Beth L, Weis, William I   +3 more
core   +2 more sources

Genome-wide Translation Profiling by Ribosome-Bound tRNA Capture

Cell Reports, 2018
Summary: In the ribosome complex, tRNA is a critical element of mRNA translation. A rich repertoire of cell regulation is hypothesized to occur during the recruitment of specific tRNAs in polypeptide formation.
Chien-Wen Chen, Motomasa Tanaka
doaj   +1 more source

Aβ Secretion and Plaque Formation Depend on Autophagy

Cell Reports, 2013
Alzheimer’s disease (AD) is a neurodegenerative disease biochemically characterized by aberrant protein aggregation, including amyloid beta (Aβ) peptide accumulation. Protein aggregates in the cell are cleared by autophagy, a mechanism impaired in AD. To
Per Nilsson, Krishnapriya Loganathan, Misaki Sekiguchi, Yukio Matsuba, Kelvin Hui, Satoshi Tsubuki, Motomasa Tanaka, Nobuhisa Iwata, Takashi Saito, Takaomi C. Saido   +9 more
doaj   +1 more source

Conformational Plasticity of HLA-B27 Molecules Correlates Inversely With Efficiency of Negative T Cell Selection [PDF]

, 2020
The development of autoimmune disorders is incompletely understood. Inefficient thymic T cell selection against self-peptides presented by major histocompatibility antigens (HLA in humans) may contribute to the emergence of auto-reactive effector cells ...
Loll, Bernhard, Rückert, Christine, Uchanska-Ziegler, Barbara, Ziegler, Andreas   +3 more
core   +1 more source

Novel ADAMTS13 mutations in a patient with congenital thrombotic thrombocytopenic purpura

Hematology, 2023
Congenital thrombotic thrombocytopenic purpura (TTP) is a rare autosomal recessive genetic disorder caused by mutations in the ADAMTS13 gene. Approximately 200 mutations of the ADAMTS-13 gene have been identified, although only a few have been ...
Zhitao Wang, Xinhui Zhang, Xueqin Lu, Peng Peng, Huiru Wang, Shanglong Feng, Li Zhou   +6 more
doaj   +1 more source