Results 11 to 20 of about 432,153 (207)
Conformational kinetics reveals affinities of protein conformational states [PDF]
Proceedings of the National Academy of Sciences, 2015 Significance Despite 50 years of studies of coupled binding and conformational change reactions in proteins and nucleic acids, there has been no detailed analysis of the affinities of the multiple conformational states involved. The relationship between these affinities and the dynamics of conformational change has also been largely ...
Daniels, Kyle G +2 more
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Pathogens, 2021 Amyloid structures assemble through a repeating type of bonding called “cross-β”, in which identical sequences in many protein molecules form β-sheets that interdigitate through side chain interactions.
Peter N. Lipke +3 more
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Frontiers in Toxicology, 2023 Cerium oxide (CeO2) nanoparticles are expected to have applications in the biomedical field because of their antioxidative properties. Inorganic nanoparticles interact with proteins at the nanoparticle surface and change their conformation when ...
Masakazu Umezawa +4 more
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Conformations of Proteins in Equilibrium [PDF]
Physical Review Letters, 2001 6 pages, 3 eps ...
Micheletti, Cristian +2 more
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Aβ Secretion and Plaque Formation Depend on Autophagy
Cell Reports, 2013 Alzheimer’s disease (AD) is a neurodegenerative disease biochemically characterized by aberrant protein aggregation, including amyloid beta (Aβ) peptide accumulation. Protein aggregates in the cell are cleared by autophagy, a mechanism impaired in AD. To
Per Nilsson +9 more
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CHIMIA, 2011 The biological properties of a protein critically depend on its conformation, which can vary as a result of changes in conditions such as pH or following the addition of various substances.
Denis Prim +2 more
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Sequence-Dependent Correlated Segments in the Intrinsically Disordered Region of ChiZ
Biomolecules, 2020 How sequences of intrinsically disordered proteins (IDPs) code for their conformational dynamics is poorly understood. Here, we combined NMR spectroscopy, small-angle X-ray scattering (SAXS), and molecular dynamics (MD) simulations to characterize the ...
Alan Hicks +3 more
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Decoding F508del Misfolding in Cystic Fibrosis
Biomolecules, 2014 The functional deficiency of the cystic fibrosis transmembrane conductance regulator (CFTR), a plasma membrane chloride channel, leads to the development of cystic fibrosis.
Xiaodong Robert Wang, Chenglong Li
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MAD1: Kinetochore Receptors and Catalytic Mechanisms
Frontiers in Cell and Developmental Biology, 2018 The mitotic checkpoint monitors kinetochore-microtubule attachment, delays anaphase onset and prevents aneuploidy when unattached or tensionless kinetochores are present in cells.
Yibo Luo, Ejaz Ahmad, Song-Tao Liu
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Epitope-Specific Serological Assays for RSV: Conformation Matters
Vaccines, 2019 Respiratory syncytial virus (RSV) causes substantial morbidity and mortality in children and older adults. An effective vaccine must elicit neutralizing antibodies targeting the RSV fusion (F) protein, which exists in two major conformations, pre-fusion (
Emily Phung +10 more
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