Results 11 to 20 of about 6,634,608 (387)

Codon usage bias regulates gene expression and protein conformation in yeast expression system P. pastoris. [PDF]

Microb Cell Fact, 2021
Background Protein synthesis is one of the extremely important anabolic pathways in the yeast expression system Pichia pastoris . Codon optimization is a commonly adopted strategy for improved protein expression, although unexpected failures did appear ...
Xu Y, Liu K, Han Y, Xing Y, Zhang Y, Yang Q, Zhou M.   +6 more
europepmc   +2 more sources

N-Glycosylation as a Modulator of Protein Conformation and Assembly in Disease. [PDF]

Biomolecules
Glycosylation, a prevalent post-translational modification, plays a pivotal role in regulating intricate cellular processes by covalently attaching glycans to macromolecules.
Pasala C, Sharma S, Roychowdhury T, Moroni E, Colombo G, Chiosis G.   +5 more
europepmc   +2 more sources

Characterizing Post-Translational Modifications and Their Effects on Protein Conformation Using NMR Spectroscopy. [PDF]

Biochemistry, 2020
The diversity of the cellular proteome substantially exceeds the number of genes coded by the DNA of an organism because one or more residues in a majority of eukaryotic proteins are post-translationally modified (PTM) by the covalent conjugation of ...
Kumar A, Narayanan V, Sekhar A.
europepmc   +2 more sources

DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability. [PDF]

Nucleic Acids Res, 2018
Proteins are highly dynamic molecules, whose function is intrinsically linked to their molecular motions. Despite the pivotal role of protein dynamics, their computational simulation cost has led to most structure-based approaches for assessing the ...
Rodrigues CH, Pires DE, Ascher DB.
europepmc   +2 more sources

Probe protein conformation [PDF]

Nature Nanotechnology, 2018
Wenjie Sun
openaire   +2 more sources

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

Science, 2020
Structure of the nCoV trimeric spike The World Health Organization has declared the outbreak of a novel coronavirus (2019-nCoV) to be a public health emergency of international concern.
D. Wrapp, Nianshuang Wang, Kizzmekia S. Corbett, J. Goldsmith, C. Hsieh, O. Abiona, B. Graham, J. McLellan   +7 more
semanticscholar   +1 more source

Genome-wide Translation Profiling by Ribosome-Bound tRNA Capture

Cell Reports, 2018
Summary: In the ribosome complex, tRNA is a critical element of mRNA translation. A rich repertoire of cell regulation is hypothesized to occur during the recruitment of specific tRNAs in polypeptide formation.
Chien-Wen Chen, Motomasa Tanaka
doaj   +1 more source

Conformational kinetics reveals affinities of protein conformational states [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance Despite 50 years of studies of coupled binding and conformational change reactions in proteins and nucleic acids, there has been no detailed analysis of the affinities of the multiple conformational states involved. The relationship between these affinities and the dynamics of conformational change has also been largely ...
Daniels, Kyle G, Suo, Yang, Oas, Terrence G   +2 more
openaire   +2 more sources

Conformations of Proteins in Equilibrium [PDF]

Physical Review Letters, 2001
6 pages, 3 eps ...
Micheletti, Cristian, J. R. BANAVAR, A. MARITAN   +2 more
openaire   +4 more sources

Brush Conformation of Polyethylene Glycol Determines the Stealth Effect of Nanocarriers in the Low Protein Adsorption Regime

Nano letters (Print), 2021
For nanocarriers with low protein affinity, we show that the interaction of nanocarriers with cells is mainly affected by the density, the molecular weight, and the conformation of polyethylene glycol (PEG) chains bound to the nanocarrier surface.
Mengyi K. Li, Shuai Jiang, J. Simon, David Paßlick, Marie-Luise Frey, M. Wagner, V. Mailänder, D. Crespy, K. Landfester   +8 more
semanticscholar   +1 more source