Results 41 to 50 of about 3,930,063 (310)

A glycoconjugate of Haemophilus influenzae Type b capsular polysaccharide with tetanus toxoid protein: hydrodynamic properties mainly influenced by the carbohydrate [PDF]

, 2016
Three important physical properties which may affect the performance of glycoconjugate vaccines against serious disease are molar mass (molecular weight), heterogeneity (polydispersity), and conformational flexibility in solution.
Harding, Stephen E., Conrath, K., Almuntari, F., Almutairi, Fahad M., Duvivier, Pierre, Harding, S. E., Adams, G. G., Morris, Gordon, Duvivier, P., Morris, Gordon A., Abdelhameed, Ali Saber, Adams, Gary G., Abdelhameed, A. S., Conrath, Karel, GSK Vaccines, Rue de l’Institut 89, B-1330 Rixensart, Belgium   +14 more
core   +1 more source

Epitope-Specific Serological Assays for RSV: Conformation Matters

Vaccines, 2019
Respiratory syncytial virus (RSV) causes substantial morbidity and mortality in children and older adults. An effective vaccine must elicit neutralizing antibodies targeting the RSV fusion (F) protein, which exists in two major conformations, pre-fusion (
Emily Phung, Lauren A. Chang, Kaitlyn M. Morabito, Masaru Kanekiyo, Man Chen, Deepika Nair, Azad Kumar, Grace L. Chen, Julie E. Ledgerwood, Barney S. Graham, Tracy J. Ruckwardt   +10 more
doaj   +1 more source

Focused conformational sampling in proteins [PDF]

The Journal of Chemical Physics, 2017
A detailed understanding of the conformational dynamics of biological molecules is difficult to obtain by experimental techniques due to resolution limitations in both time and space. Computer simulations avoid these in theory but are often too short to sample rare events reliably.
Bacci, Marco, Langini, Cassiano, Vymětal, Jiří, Caflisch, Amedeo, Vitalis, Andreas   +4 more
openaire   +4 more sources

Latherin: a surfactant protein of horse sweat and saliva [PDF]

, 2009
Horses are unusual in producing protein-rich sweat for thermoregulation, a major component of which is latherin, a highly surface-active, non-glycosylated protein.
Douglas L Bovell, Cooper, Alan, Malcolm W Kennedy, Lu Jian R., Zhao Xiubo, McDonald, R.E., John G Beeley, Fleming, R.I., Lu, J.R., Lu, Jian R., Beeley, John G., Xiubo Zhao, Lu, Jian R.; id_orcid, Flemming, Rachel I., Cooper Alan, Fleming Rachel I., Beeley, J.G., Fleming, Rachel I., Kennedy, M.W., Zhao, Xiubo, Bovell, Douglas L., McDonald Rhona E., Bovell Douglas L., Alan Cooper, Zhao, X., Cooper, A., Rhona E McDonald, Jian R Lu, Beeley John G., Kennedy, Malcolm W., McDonald, Rhona E., Bovell, D.L., Kennedy Malcolm W., Rachel I Fleming   +33 more
core   +2 more sources

Raman optical activity demonstrates poly(L-proline) II helix in the N-terminal region of the ovine prion protein: Implications for function and misfunction [PDF]

, 2004
The aqueous solution structure of the full-length recombinant ovine prion protein PrP25-233, together with that of the N-terminal truncated version PrP94-233, have been studied using vibrational Raman optical activity (ROA) and ultraviolet circular ...
Rhie, A G O, Nielsen, Kurt, Blanch, EW, Rhie, AGO, Gill, AC, Hope, James, Hecht, L, Gill, Andrew C., Gill, A C, Blanch, E W, Barron, Laurence D., Barron, L D, Nielsen, K, Hope, J, Hecht, Lutz, Barron, LD, Blanch, Ewan W., Rhie, Alexandre G. O., Rhie, Alexandre G O   +18 more
core   +1 more source

Effect of Protein Conformation and AMP Protonation State on Fireflies' Bioluminescent Emission. [PDF]

Molecules, 2019
The emitted color in fireflies’ bioluminescent systems depends on the beetle species the system is extracted from and on different external factors (pH, temperature…) among others.
Garcia-Iriepa C, Navizet I.
europepmc   +2 more sources

psp-codes/adaptive-conformation-sampling: Public Release

, 2021
This is the public release of the codes for the project detailed in the manuscript titled "Adaptive Stochastic Optimization to Improve Protein Conformation Sampling".
psp-codes
core   +1 more source

Parsimony in Protein Conformational Change [PDF]

Structure, 2015
Protein conformational change is analyzed by finding the minimalist backbone torsion angle rotations that superpose crystal structures within experimental error. Of several approaches for enforcing parsimony during flexible least-squares superposition, an ℓ(1)-norm restraint provided greatest consistency with independent indications of flexibility from
Chapman, Brynmor K., Davulcu, Omar, Skalicky, Jack J., Brüschweiler, Rafael P., Chapman, Michael S.   +4 more
openaire   +2 more sources

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

SDSL-ESR-based protein structure characterization [PDF]

, 2010
As proteins are key molecules in living cells, knowledge about their structure can provide important insights and applications in science, biotechnology, and medicine.
Hemminga, M.A., Ljubetic, A., Hemminga, M. A., Strancar, J., Urbancic, I., Kavalenka, A.A., Kavalenka, A.   +6 more
core   +1 more source