Results 41 to 50 of about 6,585,847 (336)

MAD1: Kinetochore Receptors and Catalytic Mechanisms

Frontiers in Cell and Developmental Biology, 2018
The mitotic checkpoint monitors kinetochore-microtubule attachment, delays anaphase onset and prevents aneuploidy when unattached or tensionless kinetochores are present in cells.
Yibo Luo, Ejaz Ahmad, Song-Tao Liu
doaj   +1 more source

Reactive Human Plasma Glutathione Peroxidase Mutant with Diselenide Bond Succeeds in Tetramer Formation

Antioxidants, 2022
Plasma glutathione peroxidase (GPx3) belongs to the GPx superfamily, and it is the only known secreted selenocysteine (Sec)−containing GPx in humans.
Zhenlin Fan, Qi Yan, Jian Song, Jingyan Wei   +3 more
doaj   +1 more source

Conformational Dependence of a Protein Kinase Phosphate Transfer Reaction

, 2004
Atomic motions and energetics for a phosphate transfer reaction catalyzed by the cAMP-dependent protein kinase (PKA) are calculated by plane-wave density functional theory, starting from structures of proteins crystallized in both the reactant ...
Austin, B. H. McMahon, C.-S. Tung, Cheng, Clementi, Frauenfelder, Frauenfelder, G. Henkelman, Hanggi, Johnson, Johnson, M. X. LaBute, Madhusudan, McMahon, N  meth, P. W. Fenimore, Pearson, Pinna, Smith, Songyang, Valiev, Yang, Zheng   +22 more
core   +2 more sources

Simple models of protein folding and of non--conventional drug design [PDF]

, 2004
While all the information required for the folding of a protein is contained in its amino acid sequence, one has not yet learned how to extract this information to predict the three--dimensional, biologically active, native conformation of a protein ...
Abkkevich V I, Anfinsen C B, Broglia R A Shakhnovich E I Tiana G, Brooks B R, Bryngelson J D, Bryngelson J D, D Provasi, Derrida B, Fersht A, Flory P J, G Tiana, Go N, Hänggi P, Itzhaki L S, Kramers H A, Lau K F, Metropolis N, Mezard M, Miyazawa S, Orland H, R A Broglia, Rost B, Shakhnovich E I, Smith H, Toulouse G, van Kampen N G   +25 more
core   +1 more source

p97 Disease Mutations Modulate Nucleotide-Induced Conformation to Alter Protein-Protein Interactions. [PDF]

, 2016
The AAA+ ATPase p97/VCP adopts at least three conformations that depend on the binding of ADP and ATP and alter the orientation of the N-terminal protein-protein interaction (PPI) domain into up and down conformations.
Arkin, Michelle, Bulfer, Stacie, Chou, Tsui-Fen   +2 more
core  

Is protein folding problem really a NP-complete one ? First investigations

, 2013
To determine the 3D conformation of proteins is a necessity to understand their functions or interactions with other molecules. It is commonly admitted that, when proteins fold from their primary linear structures to their final 3D conformations, they ...
Bahi, Jacques M., Bienia, Wojciech, Côté, Nathalie, Guyeux, Christophe   +3 more
core   +3 more sources

The importance of RSV F protein conformation in VLPs in stimulation of neutralizing antibody titers in mice previously infected with RSV

Human Vaccines & Immunotherapeutics, 2017
Respiratory syncytial virus (RSV) is a significant respiratory pathogen but no vaccine is available. RSV infections present 2 major, unique problems. First, humans can experience repeated infections caused by the same virus sero-group indicating that ...
Lori M Cullen, M. Schmidt, T. Morrison
semanticscholar   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Decoding F508del Misfolding in Cystic Fibrosis

Biomolecules, 2014
The functional deficiency of the cystic fibrosis transmembrane conductance regulator (CFTR), a plasma membrane chloride channel, leads to the development of cystic fibrosis.
Xiaodong Robert Wang, Chenglong Li
doaj   +1 more source

Computational Protein Design Using AND/OR Branch-and-Bound Search

, 2015
The computation of the global minimum energy conformation (GMEC) is an important and challenging topic in structure-based computational protein design.
Wu, Yuexin, Zeng, Jianyang, Zhou, Yichao
core   +1 more source