Results 51 to 60 of about 6,540,405 (386)
MAD1: Kinetochore Receptors and Catalytic Mechanisms
Frontiers in Cell and Developmental Biology, 2018 The mitotic checkpoint monitors kinetochore-microtubule attachment, delays anaphase onset and prevents aneuploidy when unattached or tensionless kinetochores are present in cells.
Yibo Luo, Ejaz Ahmad, Song-Tao Liu
doaj +1 more source
CLP-based protein fragment assembly
, 2010 The paper investigates a novel approach, based on Constraint Logic Programming (CLP), to predict the 3D conformation of a protein via fragments assembly. The fragments are extracted by a preprocessor-also developed for this work- from a database of known
AGOSTINO DOVIER +6 more
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Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance The findings in this manuscript report on the identification of a posttranslational modification in the huntingtin protein (phosphorylation on residue T3 in the N17 region of the protein), which can revert the conformational effects of the ...
Cristina Cariulo +16 more
semanticscholar +1 more source
The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach [PDF]
, 2013 The calcitonin gene-related peptide (CGRP) receptor is a complex of a calcitonin receptor-like receptor (CLR), which is a family B G-protein-coupled receptor (GPCR) and receptor activity modifying protein 1.
Alex C. Conner +13 more
core +2 more sources
The social network (of protein conformations) [PDF]
Proceedings of the National Academy of Sciences, 2011 Proteins possess thousands of degrees of freedom, and yet, they can rapidly and reliably find their way into well-defined folded configurations (1). In the cell, these folded proteins carry out highly specific motions critical to cargo transport and force transduction, energy generation, and catalysis.
John Chodera, Vijay S. Pande
openaire +3 more sources
Decoding F508del Misfolding in Cystic Fibrosis
Biomolecules, 2014 The functional deficiency of the cystic fibrosis transmembrane conductance regulator (CFTR), a plasma membrane chloride channel, leads to the development of cystic fibrosis.
Xiaodong Robert Wang, Chenglong Li
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Conformational Dependence of a Protein Kinase Phosphate Transfer Reaction
, 2004 Atomic motions and energetics for a phosphate transfer reaction catalyzed by the cAMP-dependent protein kinase (PKA) are calculated by plane-wave density functional theory, starting from structures of proteins crystallized in both the reactant ...
Austin +22 more
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Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Epitope-Specific Serological Assays for RSV: Conformation Matters
Vaccines, 2019 Respiratory syncytial virus (RSV) causes substantial morbidity and mortality in children and older adults. An effective vaccine must elicit neutralizing antibodies targeting the RSV fusion (F) protein, which exists in two major conformations, pre-fusion (
Emily Phung +10 more
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Antioxidants, 2022 Plasma glutathione peroxidase (GPx3) belongs to the GPx superfamily, and it is the only known secreted selenocysteine (Sec)−containing GPx in humans.
Zhenlin Fan +3 more
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