Results 61 to 70 of about 728,141 (364)
Lipid-protein interaction induced domains: kinetics and conformational changes in multicomponent vesicles [PDF]
, 2018 The spatio-temporal organization of proteins and the associated morphological changes in membranes are of importance in cell signaling. Several mechanisms that promote the aggregation of proteins at low cell surface concentrations have been investigated in the past.
arxiv +1 more source
Computational Protein Design Using AND/OR Branch-and-Bound Search
, 2015 The computation of the global minimum energy conformation (GMEC) is an important and challenging topic in structure-based computational protein design.
Wu, Yuexin, Zeng, Jianyang, Zhou, Yichao
core +1 more source
Conformational Dynamics Simulations of Proteins [PDF]
, 1999 Molecular dynamics (MD) simulations of proteins provide descriptions of atomic motions, which allow to relate observable properties of proteins to microscopic processes. Unfortunately, such MD simulations require an enormous amount of computer time and, therefore, are limited to time scales of nanoseconds.
Eichinger, Markus +10 more
openaire +4 more sources
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
On Hydrophobicity and Conformational Specificity in Proteins [PDF]
Biophysical Journal, 2004 In this study we examine the distribution of hydrophobic residues in a nonredundant set of monomeric globular single-domain proteins. We find that the total fraction of hydrophobic residues is roughly constant and has no discernible dependence on protein size.
openaire +3 more sources
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Nature CommunicationsN- and C-terminal α-synuclein (α-syn) truncations are prevalent in Parkinson’s disease. Effects of the N- and C-terminal residues on α-syn aggregation and fibril propagation are distinct, where the N-terminus dictates fibril structure. Here, the majority
Ryan P. McGlinchey +4 more
doaj +1 more source
CyTA - Journal of Food, 2019 The effect of bamboo shoot dietary fibre (BSDF) (0%-4%) on the gel quality, protein thermal stability and secondary structure of pork salt-soluble proteins (SSP) was investigated.
Ke Li +7 more
doaj +1 more source
Cycle-based formulations in Distance Geometry
Open Journal of Mathematical Optimization, 2023 The distance geometry problem asks to find a realization of a given simple edge-weighted graph in a Euclidean space of given dimension $K$, where the edges are realized as straight segments of lengths equal (or as close as possible) to the edge weights ...
Liberti, Leo +3 more
doaj +1 more source
Prompt-Guided Injection of Conformation to Pre-trained Protein Model [PDF]
arXiv, 2022 Pre-trained protein models (PTPMs) represent a protein with one fixed embedding and thus are not capable for diverse tasks. For example, protein structures can shift, namely protein folding, between several conformations in various biological processes.
arxiv