Results 61 to 70 of about 6,585,847 (336)

Defining essential charged residues in fibril formation of a lysosomal derived N-terminal α-synuclein truncation

Nature Communications
N- and C-terminal α-synuclein (α-syn) truncations are prevalent in Parkinson’s disease. Effects of the N- and C-terminal residues on α-syn aggregation and fibril propagation are distinct, where the N-terminus dictates fibril structure. Here, the majority
Ryan P. McGlinchey, Sashary Ramos, Emilios K. Dimitriadis, C. Blake Wilson, Jennifer C. Lee   +4 more
doaj   +1 more source

Activation of tyrosine kinases by mutation of the gatekeeper threonine. [PDF]

, 2008
Protein kinases targeted by small-molecule inhibitors develop resistance through mutation of the gatekeeper threonine residue of the active site. Here we show that the gatekeeper mutation in the cellular forms of c-ABL, c-SRC, platelet-derived growth ...
Azam, Mohammad, Daley, George, Gray, Nathanael, KURIYAN, John, Seeliger, Markus   +4 more
core   +1 more source

Effects of N-glycosylation on protein conformation and dynamics: Protein Data Bank analysis and molecular dynamics simulation study

Scientific Reports, 2015
N-linked glycosylation is one of the most important, chemically complex and ubiquitous post-translational modifications in all eukaryotes. The N-glycans that are covalently linked to proteins are involved in numerous biological processes.
Hui-Sun Lee, Yifei Qi, W. Im
semanticscholar   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach [PDF]

, 2013
The calcitonin gene-related peptide (CGRP) receptor is a complex of a calcitonin receptor-like receptor (CLR), which is a family B G-protein-coupled receptor (GPCR) and receptor activity modifying protein 1.
Alex C. Conner, Barwell J, Bruck Taddese, Christopher A. Reynolds, Conner AC, David R. Poyner, Debbie L. Hay, Harriet A. Watkins, James Barwell, Kevin J. Smith, Michael. J. Woolley, Urano D, Watkins HA, Z. Gamze Karakullukcu   +13 more
core   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

The role of C-terminal helix in the conformational transition of an arginine binding protein

Journal of Structural Biology: X, 2022
The thermotoga maritima arginine binding protein (TmArgBP) is a periplasmic binding protein that has a short helix at the C-terminal end (CTH), which is swapped between the two chains. We apply a coarse-grained structure-based model (SBM) and all-atom MD
Vinothini Santhakumar, Nahren Manuel Mascarenhas   +1 more
doaj   +1 more source

On the optimal contact potential of proteins

, 2007
We analytically derive the lower bound of the total conformational energy of a protein structure by assuming that the total conformational energy is well approximated by the sum of sequence-dependent pairwise contact energies.
Akira R. Kinjo, Anfinsen, Bastolla, Cao, Cao, Cheng, Chikenji, Fleming, Graña, Gō, Hao, Horn, Horn, Ishida, Kabakçiogˇlu, Kinjo, Kinjo, Kinjo, Kinjo, Li, Mitsutake, Miyazawa, Miyazawa, Munson, Porto, Sanzo Miyazawa, Takada, Taketomi, Vendruscolo, Vendruscolo, Vendruscolo, Vullo, Yuan   +32 more
core   +1 more source

Characteristic Temperatures of Folding of a Small Peptide [PDF]

, 1997
We perform a generalized-ensemble simulation of a small peptide taking the interactions among all atoms into account. From this simulation we obtain thermodynamic quantities over a wide range of temperatures.
Anfinsen, Boczko, Bryngelson, Bryngelson, Camacho, Chan, Dill, Ferrenberg, Honeycutt, Karplus, Klimov, Kolinski, Leopold, Levitt, M. Masuya, Merritt, Okamoto, Onuchic, Sali, Sasai, Shakhnovich, Shakhnovich, Skolnick, Taketomi, U. H. E. Hansmann, Y. Okamoto   +25 more
core   +3 more sources

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source