Results 111 to 120 of about 103,093 (251)

Combining High-Throughput Synthesis and High-Throughput Protein Crystallography for Accelerated Hit Identification. [PDF]

Angew Chem Int Ed Engl, 2021
Sutanto F, Shaabani S, Oerlemans R, Eris D, Patil P, Hadian M, Wang M, Sharpe ME, Groves MR, Dömling A.   +9 more
europepmc   +1 more source

AlphaFold2‐Guided Cyclic Peptide Stabilizer Design to Target Protein–Protein Interactions

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The control and modulation of protein–protein interactions (PPIs) is of central importance for the majority of biological processes and most biomedical applications. Stabilization of PPIs, besides inhibition, is of growing pharmaceutical interest.
Niklas Halbwedl, Martin Zacharias
wiley   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

Rapid Structural Analysis of Natural Products Using MicroED

Small, EarlyView.
The cryoEM method, MicroED used for rapid analysis and structure determination of natural products that remained unattainable by other structural biology methods ABSTRACT Structural analysis of natural products remains challenging due to their inherent complexity and limited availability.
Jieye Lin, Orel Paz, Johan Unge, Tamir Gonen   +3 more
wiley   +1 more source

Room-temperature X-ray fragment screening with serial crystallography

Nature Communications
Structural insights into protein-ligand interactions are essential for advancing drug development, with macromolecular X-ray crystallography being a cornerstone technique.
Sebastian Günther, Pontus Fischer, Marina Galchenkova, Sven Falke, Patrick Y. A. Reinke, Sreevidya Thekku Veedu, Ana Carolina Rodrigues, Johanna Senst, Daniel Elinjikkal, Lars Gumprecht, Jan Meyer, Henry N. Chapman, Miriam Barthelmess, Alke Meents   +13 more
doaj   +1 more source

Preparation of Aqueous Solutions with Information on Solids Using Natural Polymers by Solid‐State Mixing

The Chemical Record, EarlyView.
The solid‐state information, such as chiral crystal formation, crystal polymorphism, mechanochromism, room‐temperature phosphorescence, and fluorescence detection by molecular recognition, is maintained even when the functional guest molecules are solubilized in water using natural polymers.
Keita Yamana, Riku Kawasaki, Atsushi Ikeda   +2 more
wiley   +1 more source

Quantum refinement with electron diffraction and X‐ray free‐electron laser data: comparative study of ribonucleotide reductase dimetal site

Journal of Applied Crystallography, EarlyView.
For the first time quantum refinement has been performed with X‐ray free‐electron laser and microcrystal electron diffraction data for the dinuclear iron site in the R2a protein of ribonucleotide reductase. The method is shown to work well and can be used to determine the protonation state of the bridging solvent molecule and deduce photoreduction in ...
Kristoffer J. M. Lundgren, Xiaoli Sun, Laura Pacoste, Rohit Kumar, Gerhard Hofer, Hongyi Xu, Xiaodong Zou, Martin Högbom, Esko Oksanen, Ulf Ryde   +9 more
wiley   +1 more source

C-phycocyanin as a highly attractive model system in protein crystallography: unique crystallization properties and packing-diversity screening. [PDF]

Acta Crystallogr D Struct Biol, 2021
Sarrou I, Feiler CG, Falke S, Peard N, Yefanov O, Chapman H.   +5 more
europepmc   +1 more source

Protein crystallography [PDF]

Nature, 1977
openaire   +1 more source

A user‐friendly goniometer‐compatible fixed‐target platform for macromolecular crystallography at synchrotrons

Journal of Applied Crystallography, EarlyView.
A user‐friendly fixed‐target platform for serial synchrotron crystallography is described, which allows low‐background X‐ray diffraction data collection, in situ crystallization and transportation of protein microcrystals at room temperature.Fixed‐target platforms provide convenient support for microcrystals during serial X‐ray crystallography studies ...
Swagatha Ghosh, Analia Banacore, Per Norder, Monica Bjelčić, Arpitha Kabbinale, Padmini Nileshwar, Gabrielle Wehlander, Daniele de Sanctis, Shibom Basu, Julien Orlans, Adams Vallejos, Leonard M. G. Chavas, Richard Neutze, Gisela Brändén   +13 more
wiley   +1 more source