Results 161 to 170 of about 103,093 (251)
The cardiac pacemakers: A paradigm of robustness in evolutionary biology
The Journal of Physiology, EarlyView.Abstract figure legend Functional networks in living systems are formed by many thousands of gene products. In association with those networks, several genes (four in this diagram) may be sufficient, each on its own, to ensure that the function occurs. Any one of these may be removed or blocked while leaving the others to continue functioning.
Denis Noble
wiley +1 more source
Radiation damage in protein crystallography at X-ray free-electron lasers. [PDF]
Acta Crystallogr D Struct Biol, 2019 Nass K.
europepmc +1 more source
Catalytic Cycle of Neisseria meningitidis CMP-Sialic Acid Synthetase Illustrated by High-Resolution Protein Crystallography. [PDF]
Biochemistry, 2020 Matthews MM +5 more
europepmc +1 more source
Structure mirroring function: What's the ‘matter’ with the funny current?
The Journal of Physiology, EarlyView.Abstract figure legend The ‘funny’ (If) current of cardiac pacemaker cells has been first identified in the late 1970s as a major mechanism in the generation and control of cardiac pacemaking. Decades of studies have since described the properties of the funny current and of its molecular components, HCN channels, in the heart and brain, providing the ...
Andrea Saponaro, Dario DiFrancesco
wiley +1 more source
Rigid-body motion is the main source of diffuse scattering in protein crystallography. [PDF]
IUCrJ, 2019 de Klijn T +2 more
europepmc +1 more source
Applications of large‐scale artificial intelligence models in bioinformatics
Quantitative Biology, Volume 14, Issue 2, June 2026.Abstract Large‐scale artificial intelligence (AI) models can mine potential patterns from massive amounts of data and provide more accurate analyses. This capability has enabled its gradual application in various areas of bioinformatics. However, few reviews have comprehensively summarized the applications of different types of large‐scale AI models in
Mingjing Li +5 more
wiley +1 more source
Journal of Applied Toxicology, Volume 46, Issue 4, Page 1076-1082, April 2026.ABSTRACT LIN‐24, an aerolysin‐like pore‐forming protein in Caenorhabditis elegans, exemplifies how ancient cytolytic mechanisms have evolved into regulated cellular processes. Initially identified for inducing nonapoptotic, engulfment‐dependent cell death in vulval precursor cells, LIN‐24 has emerged as a multifunctional regulator of metabolism, stress
Sharoen Yu Ming Lim
wiley +1 more source
Unveiling nuclear localization signals in human arginine deiminase proteins
Protein Science, Volume 35, Issue 4, April 2026.Abstract Arginine iminohydrolases are a family of enzymes involved in the conversion of arginine to citrulline. There are five isoforms in humans (PADI1, 2, 3, 4, and 6). Some of them are observed experimentally in the cytoplasm and in the nucleus of the cell; for moving to the latter location, they must pass through the cell nuclear membrane by using ...
José L. Neira +3 more
wiley +1 more source
Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 4, Page 905-920, April 2026.ABSTRACT Anaerobic ammonium‐oxidizing (anammox) bacteria employ a unique, hydrazine‐based pathway to obtain energy from nitrite and ammonium. These organisms possess distinct Rieske/cytochrome b complexes whose precise role in anammox metabolism remains unclear, but which have been proposed to include the generation of NAD(P)H.
David Hauser +4 more
wiley +1 more source