Results 51 to 60 of about 103,740 (157)

Structures of Helicobacter pylori C-terminal protease CtpA reveal a new mode of self-contained proteolytic processing

Communications Biology
Bacterial carboxyl-terminal processing proteases (CTPs) are essential for protein quality control, signal transduction, and cell adaptation. Typically, activation of CTPs involves substrate binding to the PDZ domain or an adaptor protein.
Kailei Sun, Lili Yan, Chin Yu Mok, Pui Kin So, Sirius Pui Kam Tse, Kwok Fai Lau, Daping Wang, Huawei Zhang, Shannon Wing Ngor Au   +8 more
doaj   +1 more source

Three-dimensional electron crystallography of protein microcrystals

eLife, 2013
We demonstrate that it is feasible to determine high-resolution protein structures by electron crystallography of three-dimensional crystals in an electron cryo-microscope (CryoEM).
Dan Shi, Brent L Nannenga, Matthew G Iadanza, Tamir Gonen   +3 more
doaj   +1 more source

Neutron Protein Crystallography

Nihon Kessho Gakkaishi, 1996
The structure-function relationship of proteins is dominated by the behavior of hydrogen atoms. Neutron diffraction provides an experimental method of directly locating hydrogen atoms. We have constructed the diffractometer (BIX) dedicated for the neutron crystallography in biology at JRR-3M in Japan Atomic Energy Research Institute.
openaire   +2 more sources

The time revolution in macromolecular crystallography

Structural Dynamics
Macromolecular crystallography has historically provided the atomic structures of proteins fundamental to cellular functions. However, the advent of cryo-electron microscopy for structure determination of large and increasingly smaller and flexible ...
Georgii Khusainov, Joerg Standfuss, Tobias Weinert   +2 more
doaj   +1 more source

Development of a humanized anti-FABP4 monoclonal antibody for potential treatment of breast cancer

Breast Cancer Research
Background Breast cancer is the most common cancer in women diagnosed in the U.S. and worldwide. Obesity increases breast cancer risk without clear underlying molecular mechanisms.
Jiaqing Hao, Rong Jin, Yanmei Yi, Xingshan Jiang, Jianyu Yu, Zhen Xu, Nicholas J. Schnicker, Michael S. Chimenti, Sonia L. Sugg, Bing Li   +9 more
doaj   +1 more source

Structural basis for the assembly of the Ragulator-Rag GTPase complex

Nature Communications, 2017
mTORC1 activity is controlled through Rag GTPases, which are anchored to the lysosome through the Ragulator. Here, the authors give molecular insights into Ragulator-Rag GTPase assembly and present the crystal structures of the Ragulator alone and in ...
Ryo Yonehara, Shigeyuki Nada, Tomokazu Nakai, Masahiro Nakai, Ayaka Kitamura, Akira Ogawa, Hirokazu Nakatsumi, Keiichi I. Nakayama, Songling Li, Daron M. Standley, Eiki Yamashita, Atsushi Nakagawa, Masato Okada   +12 more
doaj   +1 more source

Using structural genomics depositions in undergraduate teaching of protein crystallography: everybody wins. [PDF]

Acta Crystallogr F Struct Biol Commun, 2023
Agirre J.
europepmc   +1 more source

High-Throughput Screening to Obtain Crystal Hits for Protein Crystallography. [PDF]

J Vis Exp, 2023
Budziszewski GR, Snell ME, Wright TR, Lynch ML, Bowman SEJ.   +4 more
europepmc   +1 more source

Protein-based Radiopharmaceuticals that target fibroblast activation protein alpha: a review of current progress

EJNMMI Radiopharmacy and Chemistry
Background Fibroblast activation protein alpha (FAP) is a serine protease that is expressed at basal levels in benign tissues but is overexpressed in a variety of pathologies, including cancer.
Abdelrahman Homedan, Darpan N. Pandya, Nicholas J. Schnicker, Thaddeus J. Wadas   +3 more
doaj   +1 more source

Mix-and-extrude: high-viscosity sample injection towards time-resolved protein crystallography. [PDF]

J Appl Crystallogr, 2023
Vakili M, Han H, Schmidt C, Wrona A, Kloos M, de Diego I, Dörner K, Geng T, Kim C, Koua FHM, Melo DVM, Rappas M, Round A, Round E, Sikorski M, Valerio J, Zhou T, Lorenzen K, Schulz J.   +18 more
europepmc   +1 more source