Results 31 to 40 of about 4,121,048 (281)

The PinX1/NPM interaction associates with hTERT in early-S phase and facilitates telomerase activation

Cell & Bioscience, 2019
Background Telomere maintenance is an important factor in tumorigenesis. PinX1 is a potent telomerase regulator which also involves in telomerase loading to telomeres.
Sai-Tim Ho, Rui Jin, Derek Hang-Cheong Cheung, Jun-Jian Huang, Pang-Chui Shaw   +4 more
doaj   +1 more source

Protein Crystallography: Achievements and Challenges

Crystals, 2023
Proteins are the most important biological macromolecules, and are involved in almost all aspects of life. Therefore, the study of the structure of proteins is of great practical and fundamental importance.
Vladimir Timofeev, Valeriya Samygina
doaj   +1 more source

Structural and Functional Investigation and Pharmacological Mechanism of Trichosanthin, a Type 1 Ribosome-Inactivating Protein

Toxins, 2018
Trichosanthin (TCS) is an RNA N-glycosidase that depurinates adenine-4324 in the conserved α-sarcin/ricin loop (α-SRL) of rat 28 S ribosomal RNA (rRNA).
Wei-Wei Shi, Kam-Bo Wong, Pang-Chui Shaw
doaj   +1 more source

Protein crystallography from the perspective of technology developments

, 2015
Early on, crystallography was a domain of mineralogy and mathematics and dealt mostly with symmetry properties and imaginary crystal lattices. This changed when Wilhelm Conrad Rontgen discovered X-rays in 1895, and in 1912, Max von Laue and his ...
Liljas, Anders,, Su, Xiao-Dong, Xiao, Junyu, Dong, Yuhui, Lund University., Zhang, Heng, Terwilliger, Thomas C., Liljas, Anders   +7 more
core   +1 more source

Lipid-protein Interactions Probed by Electron Crystallography [PDF]

, 2009
Electron crystallography is arguably the only electron cryomicroscopy (cryoEM) technique able to deliver an atomic-resolution structure of membrane proteins embedded in the lipid-bilayer.
Reichow, Steve L., Gonen, Tamir
core   +1 more source

Structural and functional insights into Ubl domain-mediated regulation of SARS-CoV-2 PLpro

Biology Direct
Background SARS-CoV-2 papain-like protease (PLpro) is essential for viral replication and immune evasion. It contains an N-terminal ubiquitin-like (Ubl) domain, whose involvement in enzymatic function remains poorly understood.
Rimanshee Arya, Janani Ganesh, Vishal Prashar, Mukesh Kumar   +3 more
doaj   +1 more source

A simple adaptation to a protein crystallography station to facilitate difference X-ray scattering studies. [PDF]

J Appl Crystallogr, 2019
The X-ray crystallography station I911-2 at MAXLab II (Lund, Sweden) has been adapted to enable difference small- and wide-angle X-ray scattering (SAXS/WAXS) data to be recorded.
Sharma A, Berntsen P, Harimoorthy R, Appio R, Sjöhamn J, Järvå M, Björling A, Hammarin G, Westenhoff S, Brändén G, Neutze R.   +10 more
europepmc   +2 more sources

Protein crystallography and infectious diseases [PDF]

Protein Science, 1994
AbstractThe current rapid growth in the number of known 3‐dimensional protein structures is producing a database of structures that is increasingly useful as a starting point for the development of new medically relevant molecules such as drugs, therapeutic proteins, and vaccines.
C L, Verlinde, E A, Merritt, F, Van den Akker, H, Kim, I, Feil, L F, Delboni, S C, Mande, S, Sarfaty, P H, Petra, W G, Hol   +9 more
openaire   +2 more sources

Crystal structure of nitrogen regulatory protein IIA(Ntr) from Neisseria meningitidis [PDF]

, 2005
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work
Nettleship, JE, Berrow, NS, Ren, JS, Joanne E Nettleship, David Alderton, Saunders, NJ, Nick S Berrow, Stammers, DK, Nigel J Saunders, Jingshan Ren, Alderton, D, Sarah Sainsbury, David K Stammers, Sainsbury, S, Owens, RJ, Raymond J Owens   +15 more
core   +1 more source

emmo-repo/domain-crystallography: v0.1.0

, 2023
What's Changed Add codeowners for Concept_Templates by @CasperWA in https://github.com/emmo-repo/domain-crystallography/pull/10 Removed equivalence between cif direct part relations and EMMO hasSpatialDirectPart by @jesper-friis in https://github.com ...
James Hester, Rickard Armiento, Jesper Friis, Casper Welzel Andersen   +3 more
core   +1 more source