Results 31 to 40 of about 103,740 (157)

Angiotensin and Endothelin Receptor Structures With Implications for Signaling Regulation and Pharmacological Targeting

Frontiers in Endocrinology, 2022
In conjunction with the endothelin (ET) type A (ETAR) and type B (ETBR) receptors, angiotensin (AT) type 1 (AT1R) and type 2 (AT2R) receptors, are peptide-binding class A G-protein-coupled receptors (GPCRs) acting in a physiologically overlapping context.
David Speck, Gunnar Kleinau, Michal Szczepek, Dennis Kwiatkowski, Rusan Catar, Aurélie Philippe, Aurélie Philippe, Patrick Scheerer, Patrick Scheerer   +8 more
doaj   +1 more source

Crystal structure of pectocin M1 reveals diverse conformations and interactions during its initial step via the ferredoxin uptake system

FEBS Open Bio
Pectocin M1 (PM1), the bacteriocin from phytopathogenic Pectobacterium carotovorum which causes soft rot disease, has a unique ferredoxin domain that allows it to use FusA of the plant ferredoxin uptake system.
Nawee Jantarit, Hideaki Tanaka, Yuxi Lin, Young‐Ho Lee, Genji Kurisu   +4 more
doaj   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio
The SARS‐CoV‐2 Nucleocapsid (N) protein plays a crucial role in genome packaging, replication, transcription, and pathogenesis, making it a promising target for antiviral drug development.
Shweta Singh, Gagan D. Gupta
doaj   +1 more source

Allosteric Activation of Bacterial Response Regulators: the Role of the Cognate Histidine Kinase Beyond Phosphorylation

mBio, 2014
Response regulators are proteins that undergo transient phosphorylation, connecting specific signals to adaptive responses. Remarkably, the molecular mechanism of response regulator activation remains elusive, largely because of the scarcity of ...
Felipe Trajtenberg, Daniela Albanesi, Natalia Ruétalo, Horacio Botti, Ariel E. Mechaly, Marcos Nieves, Pablo S. Aguilar, Larisa Cybulski, Nicole Larrieux, Diego de Mendoza, Alejandro Buschiazzo   +10 more
doaj   +1 more source

Structural vulnerability in EPCR suggests functional modulation

Scientific Reports
The endothelial protein C receptor (EPCR) is a fundamental component of the vascular system in mammals due to its contribution in maintaining blood in a non-prothrombotic state, which is crucial for overall life development.
Elena Erausquin, Adela Rodríguez-Fernández, Luis Ángel Rodríguez-Lumbreras, Juan Fernández-Recio, María Gilda Dichiara-Rodríguez, Jacinto López-Sagaseta   +5 more
doaj   +1 more source

Improvement of the Pharmacological Properties of Maize RIP by Cysteine-Specific PEGylation

Toxins, 2016
To improve the pharmacological properties of maize ribosome-inactivating protein (maize RIP) for targeting HIV-infected cells, the previously engineered TAT-fused active form of maize RIP (MOD) was further engineered for cysteine-directed PEGylation.
Ka-Yee Au, Wei-Wei Shi, Shuai Qian, Zhong Zuo, Pang-Chui Shaw   +4 more
doaj   +1 more source

New insights into structural and functional relationships between LonA proteases and ClpB chaperones

FEBS Open Bio, 2019
LonA proteases and ClpB chaperones are key components of the protein quality control system in bacterial cells. LonA proteases form a unique family of ATPases associated with diverse cellular activities (AAA+) proteins due to the presence of an unusual N‐
Tatyana V. Rotanova, Anna G. Andrianova, Arsen M. Kudzhaev, Mi Li, Istvan Botos, Alexander Wlodawer, Alla Gustchina   +6 more
doaj   +1 more source

Protein crystallography and infectious diseases [PDF]

Protein Science, 1994
AbstractThe current rapid growth in the number of known 3‐dimensional protein structures is producing a database of structures that is increasingly useful as a starting point for the development of new medically relevant molecules such as drugs, therapeutic proteins, and vaccines.
C L, Verlinde, E A, Merritt, F, Van den Akker, H, Kim, I, Feil, L F, Delboni, S C, Mande, S, Sarfaty, P H, Petra, W G, Hol   +9 more
openaire   +2 more sources

Triiodide derivatization in protein crystallography [PDF]

Acta Crystallographica Section D Biological Crystallography, 2003
Methods for producing protein derivatives using cryosoak techniques with triiodide solutions are described. The methods have been tested using six different proteins. SAD/SIRAS phasing was attempted for each protein using data measured with conventional Cu Kα X-ray equipment and synchrotron radiation.
Gwyndaf, Evans, Gérard, Bricogne
openaire   +2 more sources

Conformational landscape of soluble α-klotho revealed by cryogenic electron microscopy

Scientific Reports
α-Klotho (KLA) is a type-1 membranous protein that can associate with fibroblast growth factor receptor (FGFR) to form co-receptor for FGF23. The ectodomain of unassociated KLA is shed as soluble KLA (sKLA) to exert FGFR/FGF23-independent pleiotropic ...
Nicholas J. Schnicker, Zhen Xu, Mohammad Amir, Lokesh Gakhar, Chou-Long Huang   +4 more
doaj   +1 more source