Results 21 to 30 of about 103,740 (157)

Study of the Interaction of Sorption and Catalytic Centers in Carboxypeptidase T by X-ray Analysis

Crystals, 2021
Carboxypeptidase T (CPT; EC 3.4.17.18) from Thermoactinomyces vulgaris is a distant homolog of the highly specific pancreatic carboxypeptidase B; but has a broad substrate specificity; the source of which remains unclear.
Valerij Akparov, Vladimir Timofeev, Inna Kuranova, Ilias Khaliullin   +3 more
doaj   +1 more source

Ten Good Reasons for the Use of the Tellurium-Centered Anderson-Evans Polyoxotungstate in Protein Crystallography. [PDF]

Acc Chem Res, 2017
Bijelic A, Rompel A.
europepmc   +2 more sources

Protein Crystallography: Achievements and Challenges

Crystals, 2023
Proteins are the most important biological macromolecules, and are involved in almost all aspects of life. Therefore, the study of the structure of proteins is of great practical and fundamental importance.
Vladimir Timofeev, Valeriya Samygina
doaj   +1 more source

Structural and Functional Investigation and Pharmacological Mechanism of Trichosanthin, a Type 1 Ribosome-Inactivating Protein

Toxins, 2018
Trichosanthin (TCS) is an RNA N-glycosidase that depurinates adenine-4324 in the conserved α-sarcin/ricin loop (α-SRL) of rat 28 S ribosomal RNA (rRNA).
Wei-Wei Shi, Kam-Bo Wong, Pang-Chui Shaw
doaj   +1 more source

Macromolecular neutron crystallography at the Protein Crystallography Station (PCS) [PDF]

Acta Crystallographica Section D Biological Crystallography, 2010
The Protein Crystallography Station (PCS) at Los Alamos Neutron Science Center is a high-performance beamline that forms the core of a capability for neutron macromolecular structure and function determination. Neutron diffraction is a powerful technique for locating H atoms and can therefore provide unique information about how biological ...
Andrey, Kovalevsky, Zoe, Fisher, Hannah, Johnson, Marat, Mustyakimov, Mary Jo, Waltman, Paul, Langan   +5 more
openaire   +2 more sources

The PinX1/NPM interaction associates with hTERT in early-S phase and facilitates telomerase activation

Cell & Bioscience, 2019
Background Telomere maintenance is an important factor in tumorigenesis. PinX1 is a potent telomerase regulator which also involves in telomerase loading to telomeres.
Sai-Tim Ho, Rui Jin, Derek Hang-Cheong Cheung, Jun-Jian Huang, Pang-Chui Shaw   +4 more
doaj   +1 more source

Structural and functional insights into Ubl domain-mediated regulation of SARS-CoV-2 PLpro

Biology Direct
Background SARS-CoV-2 papain-like protease (PLpro) is essential for viral replication and immune evasion. It contains an N-terminal ubiquitin-like (Ubl) domain, whose involvement in enzymatic function remains poorly understood.
Rimanshee Arya, Janani Ganesh, Vishal Prashar, Mukesh Kumar   +3 more
doaj   +1 more source

Expression and Characterization of Relaxin Family Peptide Receptor 1 Variants

Frontiers in Pharmacology, 2022
G-protein coupled receptors (GPCR) transduce extracellular stimuli into the cell interior and are thus centrally involved in almost all physiological-neuronal processes.
David Speck, Gunnar Kleinau, Mark Meininghaus, Antje Erbe, Antje Erbe, Alexandra Einfeldt, Alexandra Einfeldt, Michal Szczepek, Patrick Scheerer, Patrick Scheerer, Vera Pütter, Vera Pütter   +11 more
doaj   +1 more source

Severe deviation in protein fold prediction by advanced AI: a case study

Scientific Reports
Artificial intelligence (AI) and deep learning are making groundbreaking strides in protein structure prediction. AlphaFold is remarkable in this arena for its outstanding accuracy in modelling proteins fold based solely on their amino acid sequences. In
Jacinto López-Sagaseta, Alejandro Urdiciain   +1 more
doaj   +1 more source

The Maturation Pathway of Nickel Urease

Inorganics, 2019
Maturation of urease involves post-translational insertion of nickel ions to form an active site with a carbamylated lysine ligand and is assisted by urease accessory proteins UreD, UreE, UreF and UreG.
Yap Shing Nim, Kam-Bo Wong
doaj   +1 more source