Results 1 to 10 of about 4,121,048 (281)

Status and perspective of protein crystallography at the first multi-bend achromat based synchrotron MAX IV [PDF]

Journal of Synchrotron Radiation
The first multi-bend achromat based synchrotron MAX IV operates two protein crystallography beamlines, BioMAX and MicroMAX. BioMAX is designed as a versatile, stable, high-throughput beamline catering for most protein crystallography experiments ...
Ana Gonzalez, Tobias Krojer, Jie Nan, Monika Bjelčić, Swati Aggarwal, Ishkan Gorgisyan, Mirko Milas, Mikel Eguiraun, Cecilia Casadei, Manoop Chenchiliyan, Andrius Jurgilaitis, David Kroon, Byungnam Ahn, John Carl Ekström, Oskar Aurelius, Dean Lang, Thomas Ursby, Marjolein M. G. M. Thunnissen   +17 more
doaj   +5 more sources

Combining High-Throughput Synthesis and High-Throughput Protein Crystallography for Accelerated Hit Identification. [PDF]

Angew Chem Int Ed Engl, 2021
Sutanto F, Shaabani S, Oerlemans R, Eris D, Patil P, Hadian M, Wang M, Sharpe ME, Groves MR, Dömling A.   +9 more
europepmc   +2 more sources

Cryo-EM structure of a functional monomeric Photosystem I from Thermosynechococcus elongatus reveals red chlorophyll cluster

Communications Biology, 2021
Çoruh, Frank et al. report the structure of monomeric Photosystem I from cyanobacteria Thermosynechoccocus elongatus BP-1. They assign monomerization-induced loss of red chlorophylls to a cluster of chlorophylls adjacent to PsaX.
Orkun Çoruh, Anna Frank, Hideaki Tanaka, Akihiro Kawamoto, Eithar El-Mohsnawy, Takayuki Kato, Keiichi Namba, Christoph Gerle, Marc M. Nowaczyk, Genji Kurisu   +9 more
doaj   +1 more source

Structure of cyanobacterial photosystem I complexed with ferredoxin at 1.97 Å resolution

Communications Biology, 2022
In order to aid the understanding of the electron transfer process within the cyanobacterial photosystem I, its structure - when complexed with Ferredoxin - is determined at 1.97 Å resolution.
Jiannan Li, Noriyuki Hamaoka, Fumiaki Makino, Akihiro Kawamoto, Yuxi Lin, Matthias Rögner, Marc M. Nowaczyk, Young-Ho Lee, Keiichi Namba, Christoph Gerle, Genji Kurisu   +10 more
doaj   +1 more source

Self-Assembling Protein Nanoparticles in the Design of Vaccines: 2022 Update

Vaccines, 2022
Vaccines constitute a pillar in the prevention of infectious diseases. The unprecedented emergence of novel immunization strategies due to the COVID-19 pandemic has again positioned vaccination as a pivotal measure to protect humankind and reduce the ...
Sergio Morales-Hernández, Nerea Ugidos-Damboriena, Jacinto López-Sagaseta   +2 more
doaj   +1 more source

Functional Importance of the Hydrophobic Residue 362 in Influenza A PB1 Subunit

Viruses, 2023
PB1, acting as the catalytic subunit of the influenza polymerase, has numerous sequentially and structurally conserved regions. It has been observed that the slight modification of residues in PB1 would greatly affect the polymerase activity and even ...
Johnson Jor-Shing Chan, Yun-Sang Tang, Chun-Yeung Lo, Pang-Chui Shaw   +3 more
doaj   +1 more source

GRB2 dimerization mediated by SH2 domain-swapping is critical for T cell signaling and cytokine production

Scientific Reports, 2023
GRB2 is an adaptor protein required for facilitating cytoplasmic signaling complexes from a wide array of binding partners. GRB2 has been reported to exist in either a monomeric or dimeric state in crystal and solution.
Aline Sandouk, Zhen Xu, Sankar Baruah, Mikaela Tremblay, Jesse B. Hopkins, Srinivas Chakravarthy, Lokesh Gakhar, Nicholas J. Schnicker, Jon C. D. Houtman   +8 more
doaj   +1 more source

Pore-Forming Cardiotoxin VVA2 (Volvatoxin A2) Variant I82E/L86K Is an Atypical Duplex-Specific Nuclease

Toxins, 2022
VVA2 (volvatoxin A chain 2) is a cardiotoxic protein purified from Volvariella volvacea. Its biological activities include hemolysis, writhing reaction, neurotoxicity, and ventricular systolic arresting activity.
Jia-Qi Lu, Jia-Wen Shou, Ka-Ching Lo, Yun-Sang Tang, Wei-Wei Shi, Pang-Chui Shaw   +5 more
doaj   +1 more source

A Sixty-Year Research and Development of Trichosanthin, a Ribosome-Inactivating Protein

Toxins, 2022
Tian Hua Fen, a herbal powder extract that contains trichosanthin (TCS), was used as an abortifacient in traditional Chinese medicine. In 1972, TCS was purified to alleviate the side effects.
Jia-Qi Lu, Kam-Bo Wong, Pang-Chui Shaw
doaj   +1 more source

Identification of a broad lipid repertoire associated to the endothelial cell protein C receptor (EPCR)

Scientific Reports, 2022
Evidence is mounting that the nature of the lipid bound to the endothelial cell protein C receptor (EPCR) has an impact on its biological roles, as observed in anticoagulation and more recently, in autoimmune disease.
Elena Erausquin, María Morán-Garrido, Jorge Sáiz, Coral Barbas, Gilda Dichiara-Rodríguez, Alejandro Urdiciain, Jacinto López-Sagaseta   +6 more
doaj   +1 more source