Results 11 to 20 of about 8,887,267 (401)

Aptamer-Based Targeted Protein Degradation.

ACS Nano, 2023
The selective removal of misfolded, aggregated, or aberrantly overexpressed protein plays an essential role in maintaining protein-dominated biological processes.
Yuan Liu, Xu Qian, Chunyan Ran, Longjie Li, Ting Fu, Danhua Su, Sitao Xie, Weihong Tan   +7 more
semanticscholar   +1 more source

Targeted protein degradation: mechanisms, strategies and application

Signal Transduction and Targeted Therapy, 2022
Traditional drug discovery mainly focuses on direct regulation of protein activity. The development and application of protein activity modulators, particularly inhibitors, has been the mainstream in drug development.
Lin Zhao, Jia Zhao, Kunhong Zhong, A. Tong, Da Jia   +4 more
semanticscholar   +1 more source

The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system

Nature Communications, 2022
Targeted protein degradation allows targeting undruggable proteins for therapeutic applications as well as eliminating proteins of interest for research purposes.
C. H. Ji, Hee Yeon Kim, Min Ju Lee, Ah Jung Heo, D. Park, Sungsu Lim, Seulgi Shin, Woo Seung Yang, Chang An Jung, Kunhong Kim, Eun Hye Jeong, Sun Ho Park, Su Bin Kim, Su Jin Lee, Jeong Eun Na, J. Kang, H. Chi, Hyun Tae Kim, Y. Kim, Bo Yeon Kim, Y. Kwon   +20 more
semanticscholar   +1 more source

LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation

Nature Chemical Biology, 2021
Selective protein degradation platforms have afforded new development opportunities for therapeutics and tools for biological inquiry. The first lysosome-targeting chimeras (LYTACs) targeted extracellular and membrane proteins for degradation by bridging
G. Ahn, S. Banik, Caitlyn L. Miller, N. Riley, J. Cochran, C. Bertozzi   +5 more
semanticscholar   +1 more source

Molecular Glues: The Adhesive Connecting Targeted Protein Degradation to the Clinic

Biochemistry, 2022
Targeted protein degradation is a rapidly exploding drug discovery strategy that uses small molecules to recruit disease-causing proteins for rapid destruction mainly via the ubiquitin–proteasome pathway.
Janet M Sasso, Rumiana Tenchov, DaSheng Wang, Linda S Johnson, Xinmei Wang, Q. Zhou   +5 more
semanticscholar   +1 more source

Engineered bioorthogonal POLY-PROTAC nanoparticles for tumour-specific protein degradation and precise cancer therapy

Nature Communications, 2022
PROteolysis TArgeting Chimeras (PROTACs) has been exploited to degrade putative protein targets. However, the antitumor performance of PROTACs is impaired by their insufficient tumour distribution.
Jing Gao, Bo Hou, Qiwen Zhu, Lei Yang, Xingyu Jiang, Zhifeng Zou, Xutong Li, Tianfeng Xu, Mingyue Zheng, Yi-Hung Chen, Zhiai Xu, Huixiong Xu, Haijun Yu   +12 more
semanticscholar   +1 more source

Targeted Protein Degradation by Electrophilic PROTACs that Stereoselectively and Site-Specifically Engage DCAF1.

Journal of the American Chemical Society, 2022
Targeted protein degradation induced by heterobifunctional compounds and molecular glues presents an exciting avenue for chemical probe and drug discovery.
Yongfeng Tao, David Remillard, E. Vinogradova, M. Yokoyama, S. Banchenko, D. Schwefel, Bruno Melillo, S. Schreiber, Xiaoyu Zhang, B. Cravatt   +9 more
semanticscholar   +1 more source

Endoplasmic Reticulum-Associated Protein Degradation.

Cold Spring Harbor Perspectives in Biology, 2022
Misfolded, potentially toxic proteins in the lumen and membrane of the endoplasmic reticulum (ER) are eliminated by proteasomes in the cytosol through ER-associated degradation (ERAD).
L. Krshnan, M. L. van de Weijer, Pedro Carvalho   +2 more
semanticscholar   +1 more source

Discovery of E3 Ligase Ligands for Target Protein Degradation

Molecules, 2022
Target protein degradation has emerged as a promising strategy for the discovery of novel therapeutics during the last decade. Proteolysis-targeting chimera (PROTAC) harnesses a cellular ubiquitin-dependent proteolysis system for the efficient ...
Jaeseok Lee, Youngjun Lee, Young Mee Jung, Ju Hyun Park, H. Yoo, Jongmin Park   +5 more
semanticscholar   +1 more source

Targeted Protein Degradation via Lysosomes.

Biochemistry, 2022
In the scope of targeted protein degradation (TPD), proteolysis-targeting chimeras (PROTACs), leveraging the ubiquitin-proteasome system, have been extensively studied.
R. Paudel, Dong Lu, S. Roy Chowdhury, Erika Y. Monroy, Jin Wang   +4 more
semanticscholar   +1 more source