Results 11 to 20 of about 1,110,261 (265)

Development of an oncogenic dedifferentiation SOX signature with prognostic significance in hepatocellular carcinoma

BMC Cancer, 2019
Background Gradual loss of terminal differentiation markers and gain of stem cell-like properties is a major hall mark of cancer malignant progression.
Mei-Mei Li, Yun-Qiang Tang, Yuan-Feng Gong, Wei Cheng, Hao-Long Li, Fan-En Kong, Wen-Jie Zhu, Shan-Shan Liu, Li Huang, Xin-Yuan Guan, Ning-Fang Ma, Ming Liu   +11 more
doaj   +1 more source

Circular RNA circIKBKB promotes breast cancer bone metastasis through sustaining NF-κB/bone remodeling factors signaling

Molecular Cancer, 2021
Background Breast cancer (BC) has a marked tendency to spread to the bone, resulting in significant skeletal complications and mortality. Recently, circular RNAs (circRNAs) have been reported to contribute to cancer initiation and progression.
Yingru Xu, Shuxia Zhang, Xinyi Liao, Man Li, Suwen Chen, Xincheng Li, Xingui Wu, Meisongzhu Yang, Miaoling Tang, Yameng Hu, Ziwen Li, Ruyuan Yu, Mudan Huang, Libing Song, Jun Li   +14 more
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NUPR1 is a critical repressor of ferroptosis

Nature Communications, 2021
Ferroptosis is a type of iron-dependent regulated cell death, representing an emerging disease-modulatory mechanism. Transcription factors play multiple roles in ferroptosis, although the key regulator for ferroptosis in iron metabolism remains elusive ...
Jiao Liu, Xinxin Song, Feimei Kuang, Qiuhong Zhang, Yangchun Xie, Rui Kang, Guido Kroemer, Daolin Tang   +7 more
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Targeting proteins for degradation [PDF]

Nature Chemical Biology, 2009
Protein degradation plays a central role in many cellular functions. Misfolded and damaged proteins are removed from the cell to avoid toxicity. The concentrations of regulatory proteins are adjusted by degradation at the appropriate time. Both foreign and native proteins are digested into small peptides as part of the adaptive immune response.
Erin K, Schrader, Kristine G, Harstad, Andreas, Matouschek   +2 more
openaire   +2 more sources

A new gold(I) complex-Au(PPh3)PT is a deubiquitinase inhibitor and inhibits tumor growthResearch in context

EBioMedicine, 2019
Background: Ubiquitin-proteasome system (UPS) is integral to cell survival by maintaining protein homeostasis, and its dysfunction has been linked to cancer and several other human diseases.
Xiaofen Li, Qingtian Huang, Huidan Long, Peiquan Zhang, Huabo Su, Jinbao Liu   +5 more
doaj   +1 more source

An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis

Nature Communications, 2020
The involvement of long non-coding RNA (lncRNA) in the regulation of N6-methyladenosine (m6A) modification of RNA is unclear. Here, the authors show that LINC00266-1 encodes a peptide that binds to m6A reader, IGF2BP1 to enhance the recognition of m6A ...
Song Zhu, Ji-Zhong Wang, De Chen, Yu-Tian He, Nan Meng, Min Chen, Rui-Xun Lu, Xin-Hui Chen, Xiao-Lan Zhang, Guang-Rong Yan   +9 more
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XBP1‐elicited environment by chemotherapy potentiates repopulation of tongue cancer cells by enhancing miR‐22/lncRNA/KAT6B‐dependent NF‐κB signalling

Clinical and Translational Medicine, 2023
Background Tumour repopulation initiated by residual tumour cells in response to cytotoxic therapy has been described clinically and biologically, but the mechanisms are unclear.
Xiaoting Jia, Ge Wang, Lihong Wu, Hao Pan, Li Ling, Jianlei Zhang, Qingquan Wen, Jie Cui, Zhimin He, Bin Qi, Shuxu Zhang, Liyun Luo, Guopei Zheng   +12 more
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Peptides/Proteins Encoded by Non-coding RNA: A Novel Resource Bank for Drug Targets and Biomarkers

Frontiers in Pharmacology, 2018
Non-coding RNAs (ncRNAs) are defined as RNA molecules that do not encode proteins, but recent evidence has proven that peptides/proteins encoded by ncRNAs do indeed exist and usually contain less than 100 amino acids.
Song Zhu, Song Zhu, Jizhong Wang, Jizhong Wang, Yutian He, Yutian He, Nan Meng, Nan Meng, Guang-Rong Yan, Guang-Rong Yan   +9 more
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Selective degradation of AR-V7 to overcome castration resistance of prostate cancer

Cell Death and Disease, 2021
Androgen receptor splice variant 7 (AR-V7), a form of ligand-independent and constitutively activating variant of androgen receptor (AR), is considered as the key driver to initiate castration-resistant prostate cancer (CRPC).
Yuan Liu, Cuifu Yu, Zhenlong Shao, Xiaohong Xia, Tumei Hu, Weiyao Kong, Xiaoyue He, Wenshuang Sun, Yuanfei Deng, Yuning Liao, Hongbiao Huang   +10 more
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Deficient DNASE1L3 facilitates neutrophil extracellular traps‐induced invasion via cyclic GMP‐AMP synthase and the non‐canonical NF‐κB pathway in diabetic hepatocellular carcinoma

Clinical & Translational Immunology, 2022
Objective Diabetic hepatocellular carcinoma (HCC) patients have high mortality and metastasis rates. Diabetic conditions promote neutrophil extracellular traps (NETs) generation, which mediates HCC metastasis and invasion.
Na Li, Xue Zheng, Mianrong Chen, Li Huang, Li Chen, Rui Huo, Xiaotong Li, Yucan Huang, Mingwen Sun, Suiqing Mai, Zhuoyi Wu, Hui Zhang, Jinbao Liu, Chun‐tao Yang   +13 more
doaj   +1 more source