Results 231 to 240 of about 1,856,978 (353)

Molecular functions of the ubiquitin domain protein Herp in Synoviolin mediated endoplasmic reticulum associated protein degradation (ERAD)

, 2010
Melanie Kny
openalex   +2 more sources

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Targeted Protein Degradation for Agricultural Applications: Rationale, Challenges, and Outlook. [PDF]

ACS Bio Med Chem Au
Fourches D, Pilotte J, Watts BE, Saltzberg DJ, Cicchillo RM.   +4 more
europepmc   +1 more source

Htm1p function in ER-associated protein degradation

, 2009
Simone Clerc
openalex   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Recent advances in glutarimide chemistry for cereblon-mediated targeted protein degradation: developments in synthesis and diversification. [PDF]

RSC Med Chem
Ba X, Dehghany M, Mortensen DS, Holmberg-Douglas N.   +3 more
europepmc   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Targeted protein degradation in Escherichia coli using CLIPPERs. [PDF]

EMBO Rep
Izert-Nowakowska MA, Klimecka MM, Antosiewicz A, Wróblewski K, Kowalski JJ, Bandyra KJ, Góral T, Kmiecik S, Serwa RA, Górna MW.   +9 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Pioneering protein degradation for agricultural applications. [PDF]

Commun Biol
Morgan GL, Dickson H, Ford B, Noras A, Bremmer SC, Watts BE, Pilotte J, Anderson E, Sullivan ED, Stoner M, Ouedraogo D, Saltzberg DJ, Pothula KR, Ingram P, Catalano J, Lillich M, Kolbe CC, Pfeiffer A, Ladner CC, Gattis S, Speake J, Voss S, Broccio K, Fourches D.   +23 more
europepmc   +1 more source