Results 271 to 280 of about 1,243,460 (313)

Ubiquitination and Degradation of Proteins

2011
Modification by ubiquitin (Ub) and ubiquitin-like proteins (UbLs) is involved in the regulation of numerous cellular processes and has therefore become an important subject of research in various areas of biomedicine. The large number of components of the system (∼1,500), most of them being ligases (∼800) that recognize their target substrates ...
Yelena, Kravtsova-Ivantsiv, Aaron, Ciechanover   +1 more
openaire   +2 more sources

Linkers for protein degradation

Nature Chemical Biology, 2018
The ability to subvert E3 ubiquitin ligases with small-molecule drugs offers tremendous promise for drug discovery. A new study demonstrates how structural and computational techniques can engineer and exploit unnatural protein–protein interfaces to design selective protein degraders.
openaire   +2 more sources

Protein degradation in bacteria

Archives of Biochemistry and Biophysics, 1953
Summary 1. Under aerobic conditions which permit growth of Escherichia coli , the rate of protein degradation, as measured by loss of labeled arginine from the acid-insoluble fraction of the culture, is at least 8 ± 2% per 30 hr. 2. When such cells grown in a synthetic medium are transferred to a secondary medium containing a complete amino ...
openaire   +2 more sources

Optochemical Control of Protein Degradation

ChemBioChem, 2020
AbstractOptochemical approach has been successfully utilized to regulate cellular protein degradation with a high resolution of spatiotemporal control. In this highlight, we discuss two recent developments of combining reversible optochemical functionalities with the bifunctional proteolysis targeting chimeras, or PROTACs to achieve light‐controlled ...
Peng Wu, Debasish Manna
openaire   +3 more sources

Eukaryotic protein degradation

Current Opinion in Cell Biology, 1990
Early studies of intracellular protein degradation revealed several properties common to all types of eukaryotic cells. Cellular proteins are continuously turning over and measurements of the fate of individual proteins have shown them to have widely differing half-lives (ranging from a few minutes to many days).
openaire   +2 more sources

Monitoring protein degradation

2002
Publisher Summary Protein degradation processes can be divided in two categories: bulk degradation and selective degradation of specific proteins. Individual protein species can differ in stability by several orders of magnitude. Constitutive fast turnover of a protein allows the rapid modulation of its concentration in response to changes in its ...
openaire   +2 more sources

Protein Degradation in Focus

Nature Chemical Biology
In May 2024, ‘Protein Degradation in Focus’, a special symposium aimed at bringing together scientists in the targeted protein degradation (TPD) field, was held in Dundee, UK. David Zollman and Kirsten McAulay report on the topics discussed and the exciting outlook for science in the TPD space.
David Zollman, Kirsten McAulay
openaire   +3 more sources

RAT MYOCARDIAL PROTEIN DEGRADATION

Clinical and Experimental Pharmacology and Physiology, 1981
SUMMARY1. Myocardial protein degradation rates were determined by following tyrosine release from rat isolated left hemi‐atria in vitro.2. After two 20 min preincubations the rate of tyrosine release from hemi‐atria was constant for 4 h.3. Skeletal muscle protein degradation was determined by following tyrosine release from rat isolated hemi‐diaphragm (
J H, Steer, B E, Hopkins
openaire   +2 more sources

Protein degradation in yeast

Biochemical Society Transactions, 1987
U, Teichert, B, Mechler, H, Müller, D H, Wolf   +3 more
openaire   +2 more sources

Protein degradation in the lysosome

Biochemical Society Transactions, 1985
H, Glaumann, J, Ahlberg, A, Berkenstam, M, Falk, F, Henell   +4 more
openaire   +2 more sources