Results 21 to 30 of about 8,887,267 (401)

PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy

Frontiers in Pharmacology, 2021
Proteolysis targeting chimeric (PROTAC) technology is an effective endogenous protein degradation tool developed in recent years that can ubiquitinate the target proteins through the ubiquitin-proteasome system (UPS) to achieve an effect on tumor growth.
Si-min Qi, Jinyun Dong, Zhiyuan Xu, Xiang-dong Cheng, Wei-Dong Zhang, Jiangjiang Qin   +5 more
semanticscholar   +1 more source

Gambogic Acid Is a Tissue-Specific Proteasome Inhibitor In Vitro and In Vivo

Cell Reports, 2013
Gambogic acid (GA) is a natural compound derived from Chinese herbs that has been approved by the Chinese Food and Drug Administration for clinical trials in cancer patients; however, its molecular targets have not been thoroughly studied.
Xiaofen Li, Shouting Liu, Hongbiao Huang, Ningning Liu, Chong Zhao, Siyan Liao, Changshan Yang, Yurong Liu, Canguo Zhao, Shujue Li, Xiaoyu Lu, Chunjiao Liu, Lixia Guan, Kai Zhao, Xiaoqing Shi, Wenbin Song, Ping Zhou, Xiaoxian Dong, Haiping Guo, Guanmei Wen, Change Zhang, Lili Jiang, Ningfang Ma, Bing Li, Shunqing Wang, Huo Tan, Xuejun Wang, Q. Ping Dou, Jinbao Liu   +28 more
doaj   +1 more source

An eIF4E-binding protein regulates katanin protein levels in C. elegans embryos. [PDF]

, 2009
In Caenorhabditis elegans, the MEI-1-katanin microtubule-severing complex is required for meiosis, but must be down-regulated during the transition to embryogenesis to prevent defects in mitosis.
DeBella, Leah, Guven-Ozkan, Tugba, Li, Wei, Lin, Rueyling, Rose, Lesilee   +4 more
core   +2 more sources

Covalently Engineered Nanobody Chimeras for Targeted Membrane Protein Degradation.

Journal of the American Chemical Society, 2021
The targeted degradation of membrane proteins would afford an attractive and general strategy for treating various diseases that remain difficult with the current proteolysis-targeting chimera (PROTAC) methodology.
Heng Zhang, Yu Han, Yuanfan Yang, Fen-chun Lin, Kexin Li, Linghao Kong, Hongxiang Liu, Yongjun Dang, Jian Lin, Peng R. Chen   +9 more
semanticscholar   +1 more source

Nickel pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via both Bcr/Abl-dependent and Bcr/Abl-independent mechanisms

Journal of Hematology & Oncology, 2016
Background Acquired imatinib (IM) resistance is frequently characterized by Bcr-Abl mutations that affect IM binding and kinase inhibition in patients with chronic myelogenous leukemia (CML).
Xiaoying Lan, Chong Zhao, Xin Chen, Peiquan Zhang, Dan Zang, Jinjie Wu, Jinghong Chen, Huidan Long, Li Yang, Hongbiao Huang, Bing Z. Carter, Xuejun Wang, Xianping Shi, Jinbao Liu   +13 more
doaj   +1 more source

Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β. [PDF]

, 2016
Mutations in human CLC-1 chloride channel are associated with the skeletal muscle disorder myotonia congenita. The disease-causing mutant A531V manifests enhanced proteasomal degradation of CLC-1.
Chen, Shu-Ching, Chen, Tsung-Yu, Hsieh, Hsin-Ying, Huang, Jing-Jia, Peng, Yi-Jheng, Tang, Chih-Yung, Wu, Chia-Ying, Wu, Hao-Han   +7 more
core   +1 more source

Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy

Journal of Hematology & Oncology, 2020
Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. A bifunctional PROTAC molecule consists of a ligand (mostly small-molecule inhibitor) of the protein of interest (POI) and a covalently ...
Xin Li, Yongcheng Song
semanticscholar   +1 more source

Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

Nature Chemical Biology, 2021
Bivalent proteolysis-targeting chimeras (PROTACs) drive protein degradation by simultaneously binding a target protein and an E3 ligase and forming a productive ternary complex.
Satomi Imaide, K. Riching, N. Makukhin, Vesna Vetma, C. Whitworth, S. Hughes, N. Trainor, Sarah D. Mahan, Nancy Murphy, A. Cowan, Kwok-Ho Chan, Conner Craigon, Andrea Testa, Chiara Maniaci, M. Urh, D. Daniels, A. Ciulli   +16 more
semanticscholar   +1 more source

Oscillations in the expression of a self-repressed gene induced by a slow transcriptional dynamics [PDF]

, 2009
We revisit the dynamics of a gene repressed by its own protein in the case where the transcription rate does not adapt instantaneously to protein concentration but is a dynamical variable.
A. Goldbeter, Benjamin Parent, C. P. Fall, Constant Vandermoëre, François Lemaire, I. S. Gradshteyn, Marc Lefranc, Pierre-Emmanuel Morant, Quentin Thommen   +8 more
core   +7 more sources

Recent Developments in PROTAC‐Mediated Protein Degradation: From Bench to Clinic

ChemBioChem, 2021
Proteolysis‐targeting chimeras (PROTACs), an emerging paradigm‐shifting technology, hijacks the ubiquitin‐proteasome system for targeted protein degradation.
Zhenyi Hu, C. Crews
semanticscholar   +1 more source