Results 21 to 30 of about 1,734,521 (378)

Platinum-containing compound platinum pyrithione suppresses ovarian tumor proliferation through proteasome inhibition

Journal of Experimental & Clinical Cancer Research, 2017
Background Ovarian carcinoma is one of the most aggressive gynecological malignant neoplasms and makes up 25–30% of all cancer cases of the female genital tract.
Hongbiao Huang, Ni Liu, Yuning Liao, Ningning Liu, Jianyu Cai, Xiaohong Xia, Zhiqiang Guo, Yanling Li, Qirong Wen, Qi Yin, Yan Liu, Qingxia Wu, Dhivya Rajakumar, Xiujie Sheng, Jinbao Liu   +14 more
doaj   +1 more source

Regulation of Protein Degradation [PDF]

The Plant Cell, 1995
of understanding of how to preserve in vivo proteolytic activities in vitro also has interfered with the identification, purification, and analyses of proteinases. Although studies using heterologous proteins or synthetic peptide substrates will continue to provide valuable information, such studies must at some point utilize in vivo substrates if the ...
openaire   +2 more sources

Development of an oncogenic dedifferentiation SOX signature with prognostic significance in hepatocellular carcinoma

BMC Cancer, 2019
Background Gradual loss of terminal differentiation markers and gain of stem cell-like properties is a major hall mark of cancer malignant progression.
Mei-Mei Li, Yun-Qiang Tang, Yuan-Feng Gong, Wei Cheng, Hao-Long Li, Fan-En Kong, Wen-Jie Zhu, Shan-Shan Liu, Li Huang, Xin-Yuan Guan, Ning-Fang Ma, Ming Liu   +11 more
doaj   +1 more source

NUPR1 is a critical repressor of ferroptosis

Nature Communications, 2021
Ferroptosis is an iron-dependent form of oxidative cell death. In this study, the authors show that NUPR1, a stress-inducible transcription factor, may be a driver of ferroptosis resistance.
Jiao Liu, Xinxin Song, Feimei Kuang, Qiuhong Zhang, Yangchun Xie, Rui Kang, Guido Kroemer, Daolin Tang   +7 more
doaj   +1 more source

Discovery of cellular regulation by protein degradation [PDF]

, 2008
What follows is a story of some of the lab’s adventures mentioned above, including the inventions of new biochemical and genetic methods. This account stems, in part, from previous descriptions of the early history of the Ub field (31,32).
Alagramam, Alexander Varshavsky, Alfageme, An, Aulner, Bachmair, Bachmair, Bakayev, Baker, Baker, Balzi, Barsoum, Bartel, Bartel, Blattes, Byrd, Chau, Ciechanover, Ciechanover, Ciechanover, Clarke, Coelho, D'Ambrosio, Damelin, Davydov, Demartino, Deming, Dinardo, Ditzel, Dohmen, Dohmen, Dohmen, Du, Dunnwald, Evans, Ferber, Finley, Finley, Finley, Fried, Garner, Geiss-Friedlander, Gisler, Glotzer, Goebl, Goldknopf, Gonda, Goto, Graciet, Grigoryev, Haering, Haggarty, Hanna, Harper, Hauf, Hershko, Hershko, Hershko, Hershko, Hershko, Hicke, Hochstrasser, Hochstrasser, Holm, Hou, Hu, Hu, Hu, Huang, Hunter, Inobe, Jentsch, Johnson, Johnson, Johnson, Johnsson, Johnsson, Kaiji, Kerppola, Kerscher, Kornberg, Kwon, Kwon, Kwon, Kwon, Kwon, Lee, Levinger, Levinger, Levinger, Levinger, Li, Lou, Lévy, Marunouchi, Matsumoto, McGrath, Meyer-Almes, Milutinovich, Minsky, Mogk, Mukhopadhyay, Nasmyth, Peters, Pickart, Rao, Roninson, Rubinsztein, Rumpf, Sasaki, Shamu, Sheng, Shintomi, Shrader, Skoufias, Soffer, Solomon, Steck, Strauss, Sundin, Sundin, Suzuki, Tarassov, Tasaki, Tasaki, Tobias, Tobias, Turner, Turner, Uemura, Uhlmann, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Varshavsky, Wang, Wilkinson, Winter, Wittke, Woelk, Xia, Xie, Xie, Yi, Zenker, Özkaynak, Özkaynak   +158 more
core   +3 more sources

Circular RNA circIKBKB promotes breast cancer bone metastasis through sustaining NF-κB/bone remodeling factors signaling

Molecular Cancer, 2021
Background Breast cancer (BC) has a marked tendency to spread to the bone, resulting in significant skeletal complications and mortality. Recently, circular RNAs (circRNAs) have been reported to contribute to cancer initiation and progression.
Yingru Xu, Shuxia Zhang, Xinyi Liao, Man Li, Suwen Chen, Xincheng Li, Xingui Wu, Meisongzhu Yang, Miaoling Tang, Yameng Hu, Ziwen Li, Ruyuan Yu, Mudan Huang, Libing Song, Jun Li   +14 more
doaj   +1 more source

Targeting proteins for degradation [PDF]

Nature Chemical Biology, 2009
Protein degradation plays a central role in many cellular functions. Misfolded and damaged proteins are removed from the cell to avoid toxicity. The concentrations of regulatory proteins are adjusted by degradation at the appropriate time. Both foreign and native proteins are digested into small peptides as part of the adaptive immune response.
Erin K, Schrader, Kristine G, Harstad, Andreas, Matouschek   +2 more
openaire   +2 more sources

Myocardial Dysfunction in an Animal Model of Cancer Cachexia [PDF]

, 2011
Aims Fatigue is a common occurrence in cancer patients regardless of tumor type or anti-tumor therapies and is an especially problematic symptom in persons with incurable tumor disease.
Crawford, Danielle, Hutchinson, Kirk R., Lucchesi, Pamela A., McCarthy, Donna O., Velten, Markus, Wold, Loren E., Xu, Hui, Youtz, Dane J.   +7 more
core   +2 more sources

Optimization of ClpXP activity and protein synthesis in an E. coli extract-based cell-free expression system. [PDF]

, 2018
Protein degradation is a fundamental process in all living cells and is essential to remove both damaged proteins and intact proteins that are no longer needed by the cell.
Joseph, Simpson, K Devaraj, Neal, M Cole, Christian, Shi, Xinying, Wu, Ti   +4 more
core   +2 more sources

XBP1‐elicited environment by chemotherapy potentiates repopulation of tongue cancer cells by enhancing miR‐22/lncRNA/KAT6B‐dependent NF‐κB signalling

Clinical and Translational Medicine, 2023
Background Tumour repopulation initiated by residual tumour cells in response to cytotoxic therapy has been described clinically and biologically, but the mechanisms are unclear.
Xiaoting Jia, Ge Wang, Lihong Wu, Hao Pan, Li Ling, Jianlei Zhang, Qingquan Wen, Jie Cui, Zhimin He, Bin Qi, Shuxu Zhang, Liyun Luo, Guopei Zheng   +12 more
doaj   +1 more source