Results 291 to 300 of about 1,734,521 (378)

Small molecule targeted protein degradation <i>via</i> the UPS: venturing beyond E3 substrate receptors. [PDF]

RSC Med Chem
Guo R, Yang F, Cherney EC.
europepmc   +1 more source

Mesenchymal Stem Cells‐Derived Extracellular Vesicles Mimetics as Osteoinductive Mediators for Bone Healing

Advanced Functional Materials, EarlyView.
Mesenchymal stem cell‐derived nanoghosts (MSC‐NGs) mimic naturally secreted extracellular vesicles (MSC‐EVs) in structure and physicochemical properties but can be synthesized at more translatable yields. As osteogenic agents, MSC‐NGs demonstrate superior outcomes compared to MSC‐EVs.
Antoine Karoichan, Ling Li, Celine J. Agnes, Bettina M. Willie, Maryam Tabrizian   +4 more
wiley   +1 more source

Unveiling p65 as the target of diphyllin in ameliorating metabolic dysfunction-associated steatotic liver disease via targeted protein degradation technology. [PDF]

Front Pharmacol
Zhu X, Zhang L, Cui W, Wang L, Xu F, Liu M, Chen S, Jiang H, He Z, Peng C, Li J.   +10 more
europepmc   +1 more source

Biosynthesis and Degradation of a Wheat Embryo Cytokinin-Binding Protein during Embryogenesis and Germination

, 1985
A. Chris Brinegar, Anne Stevens, Joan E.B. Fox   +2 more
openalex   +2 more sources

A Gym for Cells—Direct Laser Writing of Magnetic Multilayered Micro Actuators for Mechanical Stimulation of Cells

Advanced Functional Materials, EarlyView.
Surface‐attached multilayer micromagnet systems are fabricated by two‐photon crosslinking. The pillar‐shaped micro actuators consist of a soft and flexible surface‐attached cell‐repellent hydrogel layer at the bottom, acting as a hinge and a cell‐adhesive hydrophobic polymer filled with magnetic nanoparticles.
Nicolas Geid, Ayman Husari, Eleonora Galli, Lukas Leffler, Pascal Tomakidi, Jürgen Rühe   +5 more
wiley   +1 more source

Stable Radical Polymers as New Electroactive Materials: Synthesis, Properties, and Emerging Applications

Advanced Functional Materials, EarlyView.
This review covers the recent advances in the synthesis and properties of stable radical polymers (SRPs) and presents their applications in electronics, magnetics, optoelectronics, and biomedicines. The review concludes with a discussion of the challenges in radical chemistry and functionalization, while shedding light on the groundbreaking potential ...
Yufeng Xiong, Yingjiang Li, Xinfang Cui, Shiwei Li, Xiangdong Peng, Yanyun Ju, Tong Zhou, Rui Feng, Yang Zhang, Zehong Wang, Qing Wang, Lijie Dong   +11 more
wiley   +1 more source

Muscle peripheral circadian clock drives nocturnal protein degradation via raised Ror/Rev-erb balance and prevents premature sarcopenia. [PDF]

Proc Natl Acad Sci U S A
Kelu JJ, Hughes SM.
europepmc   +1 more source

Sonochemical Functionalization of Glass

Advanced Functional Materials, EarlyView.
A new method for functionalizing glass using ultrasonication of aryl diazonium salts. Aryl radicals generated by ultrasounds react with glass, forming a stable, covalently bonded organic film. The functionalized glass adheres microorganisms such as microalgae, fungi, and bacteria, suggesting potential applications in enzyme production, filtration ...
Tiexin Li, Zane Datson, Sufia Hena, Steven Chang, Shane Werry, Leqi Zhao, Nasim Amiralian, Tejas Bhatelia, Francisco J. Lopez‐Ruiz, Melanie MacGregor, K. Swaminathan Iyer, Simone Ciampi, Muhammad J. A. Shiddiky, Nadim Darwish   +13 more
wiley   +1 more source

Stabilization of MYC G-quadruplex DNA by ruthenium (II) complex overcomes imatinib resistance in chronic myeloid leukemia cells harboring T315I mutation

Genes and Diseases, 2023
Yuening Sun, Xin Chen, Siyan Liao, Aochu Liu, Huan Zhou, Liling Jiang, Wa Ding, Wenjie Mei, Jinbao Liu, Xianping Shi   +9 more
doaj  

Oversized cells activate global proteasome-mediated protein degradation to maintain cell size homeostasis. [PDF]

Elife
Liu S, Tan C, Melo-Gavin C, Ginzberg MB, Blutrich R, Patel N, Rape M, Mark KG, Kafri R.   +8 more
europepmc   +1 more source