Results 41 to 50 of about 8,887,267 (401)

Nbr1 Is a Novel Inhibitor of Ligand-Mediated Receptor Tyrosine Kinase Degradation [PDF]

, 2010
endocytic trafficking and selective autophagy. However, the exact function of Nbr1 in these contexts has not been studied in detail. Here we investigated the role of Nbr1 in the trafficking of receptor tyrosine kinases (RTKs).
Auciello, Giulio, Dafforn, Tim R., Heath, John K, Mardakheh, Faraz K., Rappoport, Joshua Z.   +4 more
core   +2 more sources

Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation.

Journal of the American Chemical Society, 2021
Proteolysis targeting chimeras (PROTACs) represent a new class of promising therapeutic modalities. PROTACs hijack E3 ligases and the ubiquitin-proteasome system (UPS), leading to selective degradation of the target proteins. However, only a very limited
Jieli Wei, Fanye Meng, Kwang-Su Park, Hyerin Yim, J. Velez, Prashasti Kumar, Li Wang, Ling Xie, He Chen, Yudao Shen, Emily M Teichman, Dongxu Li, G. Wang, Xian Chen, H. Kaniskan, Jian Jin   +15 more
semanticscholar   +1 more source

NUPR1 is a critical repressor of ferroptosis

Nature Communications, 2021
Ferroptosis is a type of iron-dependent regulated cell death, representing an emerging disease-modulatory mechanism. Transcription factors play multiple roles in ferroptosis, although the key regulator for ferroptosis in iron metabolism remains elusive ...
Jiao Liu, Xinxin Song, Feimei Kuang, Qiuhong Zhang, Yangchun Xie, Rui Kang, Guido Kroemer, Daolin Tang   +7 more
doaj   +1 more source

Identification of a WNT5A-Responsive Degradation Domain in the Kinesin Superfamily Protein KIF26B. [PDF]

, 2018
Noncanonical WNT pathways function independently of the β-catenin transcriptional co-activator to regulate diverse morphogenetic and pathogenic processes.
Choi, Shannon S, Cohen, Michael, Fierro, Fernando A, Ho, Hsin-Yi Henry, Hum, Jennie, Karuna, Edith P, Scales, Michael K   +6 more
core   +2 more sources

Dissecting apoptosis the omics way [PDF]

, 2013
A combined analysis of transcription, translation and protein degradation reveals the global effects of an anticancer drug on tumour ...
Agard, Gerashchenko, Ingolia, Ingolia, Jager, Mahrus, Obeng, Rutkowski, Wiita   +8 more
core   +2 more sources

Emerging protein degradation strategies: expanding the scope to extracellular and membrane proteins

Theranostics, 2021
Classic small molecule inhibitors that directly target pathogenic proteins typically rely on the accessible binding sites to achieve prolonged occupancy and influence protein functions.
Jia-Yi Lin, Jinmei Jin, Yiwen Shen, Li-Jun Zhang, Gang Gong, Hui-Ting Bian, Hongzhuan Chen, D. Nagle, Ye Wu, Weidong Zhang, Xin Luan   +10 more
semanticscholar   +1 more source

XBP1‐elicited environment by chemotherapy potentiates repopulation of tongue cancer cells by enhancing miR‐22/lncRNA/KAT6B‐dependent NF‐κB signalling

Clinical and Translational Medicine, 2023
Background Tumour repopulation initiated by residual tumour cells in response to cytotoxic therapy has been described clinically and biologically, but the mechanisms are unclear.
Xiaoting Jia, Ge Wang, Lihong Wu, Hao Pan, Li Ling, Jianlei Zhang, Qingquan Wen, Jie Cui, Zhimin He, Bin Qi, Shuxu Zhang, Liyun Luo, Guopei Zheng   +12 more
doaj   +1 more source

β-Catenin is a pH sensor with decreased stability at higher intracellular pH. [PDF]

, 2018
β-Catenin functions as an adherens junction protein for cell-cell adhesion and as a signaling protein. β-catenin function is dependent on its stability, which is regulated by protein-protein interactions that stabilize β-catenin or target it for ...
Aberle, Baumgartner, Bree K. Grillo-Hill, Chairoungdua, Choi, Choi, Cold Spring Harbor Protocols, Dai, Daugherty, Denker, Denker, Diane L. Barber, Endo, Forbes, Forbes, Frantz, Frescas, Grillo-Hill, Ha, Hart, Ismahan Chire, Jobelle Peralta, Katharine A. White, Klaus, Krausova, Lee, Li, Liu, Liu, Mario Esquivel, Megy, Morin, Pai, Parks, Peifer, Peifer, Petherick, Pronobis, Reim, Reshkin, Sadot, Sahai-Hernandez, Schönichen, Sedgwick, Shafique, Simons, Stamos, Stehbens, Ulmschneider, Valenta, Vivian N. Bui, Waghmare, Webb, White, White, Wolff, Wu   +56 more
core   +1 more source

A new gold(I) complex-Au(PPh3)PT is a deubiquitinase inhibitor and inhibits tumor growthResearch in context

EBioMedicine, 2019
Background: Ubiquitin-proteasome system (UPS) is integral to cell survival by maintaining protein homeostasis, and its dysfunction has been linked to cancer and several other human diseases.
Xiaofen Li, Qingtian Huang, Huidan Long, Peiquan Zhang, Huabo Su, Jinbao Liu   +5 more
doaj   +1 more source

An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis

Nature Communications, 2020
The involvement of long non-coding RNA (lncRNA) in the regulation of N6-methyladenosine (m6A) modification of RNA is unclear. Here, the authors show that LINC00266-1 encodes a peptide that binds to m6A reader, IGF2BP1 to enhance the recognition of m6A ...
Song Zhu, Ji-Zhong Wang, De Chen, Yu-Tian He, Nan Meng, Min Chen, Rui-Xun Lu, Xin-Hui Chen, Xiao-Lan Zhang, Guang-Rong Yan   +9 more
doaj   +1 more source