Results 41 to 50 of about 1,734,521 (378)
Clinical & Translational Immunology, 2022 Objective Diabetic hepatocellular carcinoma (HCC) patients have high mortality and metastasis rates. Diabetic conditions promote neutrophil extracellular traps (NETs) generation, which mediates HCC metastasis and invasion.
Na Li +13 more
doaj +1 more source
Unfolding knots by proteasome-like systems: simulations of the behaviour of folded and neurotoxic proteins [PDF]
Molecular BioSystems 2016: 12 (9), 2700-2712, 2016 Knots in proteins have been proposed to resist proteasomal degradation. Ample evidence associates proteasomal degradation with neurodegeneration. One interesting possibility is that indeed knotted conformers stall this machinery leading to toxicity. However, although the proteasome is known to unfold mechanically its substrates, at present there are no
arxiv +1 more source
Membrane-bound β-catenin degradation is enhanced by ETS2-mediated Siah1 induction in Helicobacter pylori-infected gastric cancer cells. [PDF]
, 2017 β-catenin has two different cellular functions: intercellular adhesion and transcriptional activity. The E3 ubiquitin ligase Siah1 causes ubiquitin-mediated degradation of the cytosolic β-catenin and therefore, impairs nuclear translocation and oncogenic
Bhattacharyya, A +7 more
core +1 more source
Broad Spectrum Deubiquitinase Inhibition Induces Both Apoptosis and Ferroptosis in Cancer Cells
Frontiers in Oncology, 2020 Proteasomal deubiquitinase (DUB) inhibition has been found to be effective in experimental cancer therapy by inducing proteasome inhibition and apoptosis. Ferroptosis is a form of regulated cell death characterized by an iron-dependent lipid peroxidation.
Li Yang +13 more
doaj +1 more source
Advanced Science, 2022 Tumor‐derived extracellular vesicles (EVs) function as critical mediators in selective modulation of the microenvironment of distant organs to generate a pre‐metastatic niche that facilitates organotropic metastasis.
Shuxia Zhang +16 more
doaj +1 more source
Dissecting apoptosis the omics way [PDF]
, 2013 A combined analysis of transcription, translation and protein degradation reveals the global effects of an anticancer drug on tumour ...
Agard +8 more
core +2 more sources
Stem Cell Reports, 2017 Although valproic acid (VPA), has been shown to induce neuronal differentiation of neural stem cells (NSCs), the underlying mechanisms remain poorly understood. Here we investigated if and how mammalian target of rapamycin (mTOR) signaling is involved in
Xi Zhang +13 more
doaj +1 more source
Exactly solvable model of gene expression in proliferating bacterial cell population with stochastic protein bursts and protein partitioning [PDF]
, 2019 Many of the existing stochastic models of gene expression contain the first-order decay reaction term that may describe active protein degradation or dilution. If the model variable is interpreted as the molecule number, and not concentration, the decay term may also approximate the loss of protein molecules due to cell division as a continuous ...
arxiv +1 more source
Tunable protein degradation in bacteria [PDF]
Nature Biotechnology, 2014 Tunable control of protein degradation in bacteria would provide a powerful research tool. Here we use components of the Mesoplasma florum transfer-messenger RNA system to create a synthetic degradation system that provides both independent control of steady-state protein level and inducible degradation of targeted proteins in Escherichia coli.
Cameron, D. Ewen, Collins, James
openaire +3 more sources
Self-degradation of heat shock proteins [PDF]
, 1985 The 70-kDa heat shock protein of Drosophila decays in vivo at a much faster rate than other abundantly labeled proteins. Degradation also occurs in vitro, even during electrophoresis. It appears that this degradation is not mediated by a general protease
Buzin, Carolyn H. +2 more
core +1 more source