Results 51 to 60 of about 8,887,267 (401)

Peptides/Proteins Encoded by Non-coding RNA: A Novel Resource Bank for Drug Targets and Biomarkers

Frontiers in Pharmacology, 2018
Non-coding RNAs (ncRNAs) are defined as RNA molecules that do not encode proteins, but recent evidence has proven that peptides/proteins encoded by ncRNAs do indeed exist and usually contain less than 100 amino acids.
Song Zhu, Song Zhu, Jizhong Wang, Jizhong Wang, Yutian He, Yutian He, Nan Meng, Nan Meng, Guang-Rong Yan, Guang-Rong Yan   +9 more
doaj   +1 more source

Selective degradation of AR-V7 to overcome castration resistance of prostate cancer

Cell Death and Disease, 2021
Androgen receptor splice variant 7 (AR-V7), a form of ligand-independent and constitutively activating variant of androgen receptor (AR), is considered as the key driver to initiate castration-resistant prostate cancer (CRPC).
Yuan Liu, Cuifu Yu, Zhenlong Shao, Xiaohong Xia, Tumei Hu, Weiyao Kong, Xiaoyue He, Wenshuang Sun, Yuanfei Deng, Yuning Liao, Hongbiao Huang   +10 more
doaj   +1 more source

Deficient DNASE1L3 facilitates neutrophil extracellular traps‐induced invasion via cyclic GMP‐AMP synthase and the non‐canonical NF‐κB pathway in diabetic hepatocellular carcinoma

Clinical & Translational Immunology, 2022
Objective Diabetic hepatocellular carcinoma (HCC) patients have high mortality and metastasis rates. Diabetic conditions promote neutrophil extracellular traps (NETs) generation, which mediates HCC metastasis and invasion.
Na Li, Xue Zheng, Mianrong Chen, Li Huang, Li Chen, Rui Huo, Xiaotong Li, Yucan Huang, Mingwen Sun, Suiqing Mai, Zhuoyi Wu, Hui Zhang, Jinbao Liu, Chun‐tao Yang   +13 more
doaj   +1 more source

Ubiquinol Reduces Muscle Wasting but Not Fatigue in Tumor-Bearing Mice [PDF]

, 2014
Purpose: Fatigue is the most common and distressing symptom reported by cancer patients during and after treatment. Tumor growth increases oxidative stress and cytokine production, which causes skeletal muscle wasting and cardiac dysfunction. The purpose
Clark, Yvonne, McCarthy, Donna O., Szalacha, Laura A., Wold, Loren E.   +3 more
core   +2 more sources

Targeted protein degradation: advances in drug discovery and clinical practice

Signal Transduction and Targeted Therapy
Targeted protein degradation (TPD) represents a revolutionary therapeutic strategy in disease management, providing a stark contrast to traditional therapeutic approaches like small molecule inhibitors that primarily focus on inhibiting protein function.
Guangcai Zhong, Xiaoyu Chang, Weilin Xie, Xiangxiang Zhou   +3 more
semanticscholar   +1 more source

Chemical-Mediated Targeted Protein Degradation in Neurodegenerative Diseases

Life, 2021
Neurodegenerative diseases, including Alzheimer’s disease, Huntington’s disease, and Parkinson’s disease, are a class of diseases that lead to dysfunction of cognition and mobility.
Soonsil Hyun, Dongyun Shin
semanticscholar   +1 more source

Inhibition of IRE1α-mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response [PDF]

, 2017
Background: The mammalian endoplasmic reticulum (ER) continuously adapts to the cellular secretory load by the activation of an unfolded protein response (UPR).
Bulleid, Neil J., Cain, Katharine, Chalmers, Fiona, Sweeney, Bernadette, van Lith, Marcel   +4 more
core   +2 more sources

Large Oncosome‐Loaded VAPA Promotes Bone‐Tropic Metastasis of Hepatocellular Carcinoma Via Formation of Osteoclastic Pre‐Metastatic Niche

Advanced Science, 2022
Tumor‐derived extracellular vesicles (EVs) function as critical mediators in selective modulation of the microenvironment of distant organs to generate a pre‐metastatic niche that facilitates organotropic metastasis.
Shuxia Zhang, Xinyi Liao, Suwen Chen, Wanying Qian, Man Li, Yingru Xu, Meisongzhu Yang, Xincheng Li, Shuang Mo, Miaoling Tang, Xingui Wu, Yameng Hu, Ziwen Li, Ruyuan Yu, Ainiwaerjiang Abudourousuli, Libing Song, Jun Li   +16 more
doaj   +1 more source

PI3K/AKT/mTOR Signaling Mediates Valproic Acid-Induced Neuronal Differentiation of Neural Stem Cells through Epigenetic Modifications

Stem Cell Reports, 2017
Although valproic acid (VPA), has been shown to induce neuronal differentiation of neural stem cells (NSCs), the underlying mechanisms remain poorly understood. Here we investigated if and how mammalian target of rapamycin (mTOR) signaling is involved in
Xi Zhang, Xiaosong He, Qingqing Li, Xuejian Kong, Zhenri Ou, Le Zhang, Zhuo Gong, Dahong Long, Jianhua Li, Meng Zhang, Weidong Ji, Wenjuan Zhang, Liping Xu, Aiguo Xuan   +13 more
doaj   +1 more source

Broad Spectrum Deubiquitinase Inhibition Induces Both Apoptosis and Ferroptosis in Cancer Cells

Frontiers in Oncology, 2020
Proteasomal deubiquitinase (DUB) inhibition has been found to be effective in experimental cancer therapy by inducing proteasome inhibition and apoptosis. Ferroptosis is a form of regulated cell death characterized by an iron-dependent lipid peroxidation.
Li Yang, Li Yang, Xin Chen, Qianqian Yang, Jinghong Chen, Jinghong Chen, Qingtian Huang, Leyi Yao, Ding Yan, Jiawen Wu, Peiquan Zhang, Daolin Tang, Nanshan Zhong, Jinbao Liu   +13 more
doaj   +1 more source