Insomnia impairs muscle function via regulating protein degradation and muscle clock [PDF]
arXiv, 2023 Background: Insomnia makes people more physically unable of doing daily duties, which results in a lack of strength, leads to lacking in strength. However, the effects of insomnia on muscle function have not yet been thoroughly investigated. So, the objectives of this study were to clarify how insomnia contributes to the decrease of muscular function ...
arxiv
How are tonoplast proteins degraded? [PDF]
Plant Signaling & Behavior, 2011 Protein turnover is fundamental both for development and cellular homeostasis. The mechanisms responsible for the turnover of integral membrane proteins in plant cells are however still largely unknown. Recently, considerable attention has been devoted to the degradation of plasma membrane proteins.
Maîtrejean M, Vitale A
openaire +4 more sources
Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders
Nature CommunicationsThe ubiquitin E3 ligase cereblon (CRBN) is the target of therapeutic drugs thalidomide and lenalidomide and is recruited by most targeted protein degraders (PROTACs and molecular glues) in clinical development. Biophysical and structural investigation of
Alena Kroupova +17 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2019 Background The first line therapy for patients with diffuse large B cell (DLBCL) is R-CHOP. About half of DLBCL patients are either refractory to, or will relapse, after the treatment.
Liling Jiang +9 more
doaj +1 more source
The ARF-AID system: Methods that preserve endogenous protein levels and facilitate rapidly inducible protein degradation [PDF]
arXiv, 2020 The ARF-AID (Auxin Response Factor-Auxin Inducible Degron) system is a re-engineered auxin-inducible protein degradation system. Inducible degron systems are widely used to specifically and rapidly deplete proteins of interest in cell lines and organisms. An advantage of inducible degradation is that the biological system under study remains intact and
arxiv
MD simulations and experiments of plasma proteins adsorption to the biodegradable magnesium alloys to facilitate cell response [PDF]
arXiv, 2022 Once the magnesium alloy was implanted in the body, it was immediately covered with plasma proteins. The coated alloy surface promoted the adsorption and growth of osteoblasts. Herein, in vitro biological reactions of the ZK60 and AZ31 magnesium alloys were analyzed with and without plasma proteins incubation.
arxiv
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Oscillations in the expression of a self-repressed gene induced by a slow transcriptional dynamics [PDF]
, 2009 We revisit the dynamics of a gene repressed by its own protein in the case where the transcription rate does not adapt instantaneously to protein concentration but is a dynamical variable.
Pierre-Emmanuel Morant +8 more
core +7 more sources
Optimal regulation of protein degradation to schedule cellular events with precision [PDF]
, 2015 An important occurrence in many cellular contexts is the crossing of a prescribed threshold by a regulatory protein. The timing of such events is stochastic as a consequence of the innate randomness in gene expression. A question of interest is to understand how gene expression is regulated to achieve precision in event timing.
arxiv +1 more source
FlexVDW: A machine learning approach to account for protein flexibility in ligand docking [PDF]
arXiv, 2023 Most widely used ligand docking methods assume a rigid protein structure. This leads to problems when the structure of the target protein deforms upon ligand binding. In particular, the ligand's true binding pose is often scored very unfavorably due to apparent clashes between ligand and protein atoms, which lead to extremely high values of the ...
arxiv