Results 151 to 160 of about 5,918,106 (339)

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Effect of high-pressure treatment at various temperatures on indigenous proteolytic enzymes and whey protein denaturation in bovine milk

, 2008
Golfo Moatsou, C. Bakopanos, Dimitis Katharios, George Katsaros, I. Kandarakis, Petros Taoukis, I. Politis   +6 more
openalex   +1 more source

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

Thermal denaturation of soybean protein at low water contents.

, 1990
Naofumi Kitabatake, Mineo Tahara, Etsushiro Doi   +2 more
openalex   +2 more sources

Protein Denaturation in Complex Solvents: Using FTIR Spectroscopy to Understand Cryopreservation

, 2020
Kavya Rajesh
openalex   +1 more source

Efficient Light Harvesting and Water Retention Realized by Soybean Protein‐Based Microgels Embedded in Hybrid Sodium Alginate Hydrogels Containing Photocatalyst for Hydrogen Evolution

Advanced Science, EarlyView.
By incorporating SPN/SA microgels into SA hydrogels containing g‐C3N4/Pt nanosheets, highly efficient light absorption and superior water retention are achieved, thereby significantly enhancing hydrogen evolution efficiency. This is because microgels act as light scattering centers, enabling effective scattering of incident light and improving light ...
Jie Yu, Neng Hu, Weijia Wang, Lin Lei, Huiqing Fan, Peter Müller‐Buschbaum, Qi Zhong   +6 more
wiley   +1 more source

Urea denaturation by stronger dispersion interactions with proteins than water implies a 2-stage unfolding

, 2008
Lan Hua, Ruhong Zhou, D. Thirumalai, B. J. Berne   +3 more
openalex   +1 more source

Rupestonic Acid of Artemisia Rupestris L. Extract Treats Pulmonary Fibrosis in COPD by Targeting TGF‐β1

Advanced Science, EarlyView.
RA of EEAR inhibits TGF‐β1 ubiquitination and changes conformation by target binding TGF‐β1, regulating TGF‐β1/Smad2/3 signaling pathway. Thus it down‐regulated downstream protein expression, inhibited EMT and collagen deposition of ECM, in order to EEAR preventing PF in COPD.
Lingfeng Peng, Lulu Zhang, Yimeng Fan, Sijuan Huang, Qingyu Zhao, Chao Han, Zhihui Hao   +6 more
wiley   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Denaturation of Globular Proteins

Journal of Biological Chemistry, 1968
John R. Warren, Julius A. Gordon
openaire   +1 more source