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Protein disulfide isomerase in cardiovascular disease [PDF]
Experimental and Molecular Medicine, 2020 Exploring enzymes’ influence on cardiovascular disease Efforts to untangle the functions of a large family of enzymes could lead researchers to new therapies for diverse cardiovascular diseases.
Bei Xiong +3 more
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Frontiers in Immunology, 2022 BackgroundProtein disulfide isomerase A3 (PDIA3) is a member of the protein disulfide isomerase (PDI) family that participates in protein folding through its protein disulfide isomerase function.
Zewei Tu +18 more
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Functions and mechanisms of protein disulfide isomerase family in cancer emergence [PDF]
Cell & Bioscience, 2022 The endoplasmic reticulum (ER) is a multi-layered organelle that is essential for the synthesis, folding, and structural maturation of almost one-third of the cellular proteome.
Nisa Syakila A. Rahman +5 more
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Roles of Protein Disulfide Isomerase in Breast Cancer [PDF]
Cancers, 2022 Simple Summary Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and has a poor prognosis and higher recurrence rate due to ineffective therapy.
Suhui Yang +8 more
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Protein Disulfide Isomerase and Host-Pathogen Interaction [PDF]
The Scientific World Journal, 2011 Reactive oxygen species (ROS) production by immunological cells is known to cause damage to pathogens. Increasing evidence accumulated in the last decade has shown, however, that ROS (and redox signals) functionally regulate different cellular pathways ...
Beatriz S. Stolf +7 more
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Compact conformations of human protein disulfide isomerase. [PDF]
PLoS ONE, 2014 Protein disulfide isomerase (PDI) composed of four thioredoxin-like domains a, b, b', and a', is a key enzyme catalyzing oxidative protein folding in the endoplasmic reticulum.
Shang Yang +8 more
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The human protein disulfide isomerase gene family [PDF]
Human Genomics, 2012 Enzyme-mediated disulfide bond formation is a highly conserved process affecting over one-third of all eukaryotic proteins. The enzymes primarily responsible for facilitating thiol-disulfide exchange are members of an expanding family of proteins known ...
Galligan James J, Petersen Dennis R
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Emerging roles of protein disulfide isomerase in cancer
BMB Reports, 2017 The protein disulfide isomerase (PDI) family is a group of multifunctional endoplasmic reticulum (ER) enzymes that mediate the formation of disulfide bonds, catalyze the cysteine-based redox reactions and assist the quality control of client proteins ...
Eunyoug Lee, Do Hee Lee
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Protein disulfide isomerase mediates integrin‐dependent adhesion [PDF]
FEBS Letters, 2000 Cell adhesion is mediated by the integrin adhesion receptors. Receptor–ligand interaction involves conformational changes in the receptor, but the underlying mechanism remains unclear. Our earlier work implied a role for sulfhydryls in integrin response to ligand binding in the intact blood platelet.
Judith Lahav +4 more
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Dual roles for a tick protein disulfide isomerase during the life cycle of the Lyme disease agent [PDF]
mBioThe protein disulfide isomerase (PDI) family is a group of enzymes that have thiol-disulfide oxidoreductase, disulfide isomerase, and redox-dependent chaperone activities.
Xiaotian Tang +5 more
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