Results 1 to 10 of about 63,740 (215)

Functions and mechanisms of protein disulfide isomerase family in cancer emergence [PDF]

open access: yesCell & Bioscience, 2022
The endoplasmic reticulum (ER) is a multi-layered organelle that is essential for the synthesis, folding, and structural maturation of almost one-third of the cellular proteome.
Nisa Syakila A. Rahman   +5 more
doaj   +3 more sources

Protein Disulfide-Isomerase A3 Is a Robust Prognostic Biomarker for Cancers and Predicts the Immunotherapy Response Effectively

open access: yesFrontiers in Immunology, 2022
BackgroundProtein disulfide isomerase A3 (PDIA3) is a member of the protein disulfide isomerase (PDI) family that participates in protein folding through its protein disulfide isomerase function.
Zewei Tu   +18 more
doaj   +2 more sources

Protein disulfide isomerase in cardiovascular disease

open access: yesExperimental and Molecular Medicine, 2020
Exploring enzymes’ influence on cardiovascular disease Efforts to untangle the functions of a large family of enzymes could lead researchers to new therapies for diverse cardiovascular diseases.
Bei Xiong   +3 more
doaj   +2 more sources

Roles of Protein Disulfide Isomerase in Breast Cancer. [PDF]

open access: yesCancers (Basel), 2022
Simple Summary Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and has a poor prognosis and higher recurrence rate due to ineffective therapy.
Yang S   +8 more
europepmc   +2 more sources

Dual roles for a tick protein disulfide isomerase during the life cycle of the Lyme disease agent [PDF]

open access: yesmBio
The protein disulfide isomerase (PDI) family is a group of enzymes that have thiol-disulfide oxidoreductase, disulfide isomerase, and redox-dependent chaperone activities.
Xiaotian Tang   +5 more
doaj   +2 more sources

Protein disulfide isomerase A3 as novel biomarker for endometrial cancer [PDF]

open access: yesFrontiers in Oncology, 2023
ObjectiveThis study aims to investigate the potential of PDIA3 as a novel prognostic biomarker and therapeutic target for Endometrial Cancer (EC) with the ultimate goal of improving survival rates in EC patients.MethodsThis study employed a combination ...
Fanrong Yu   +6 more
doaj   +2 more sources

Protein disulfide isomerase is essential for osteoblast differentiation in mice [PDF]

open access: yesCommunications Biology
Protein disulfide isomerase (PDI) is an oxidoreductase responsible for the formation, reduction and isomerization of disulfide bonds of nascent proteins in endoplasmic reticulum (ER).
Yue Lu   +5 more
doaj   +2 more sources

Identification and Functional Analysis of a Protein Disulfide Isomerase (AtPDI1) in Arabidopsis thaliana

open access: yesFrontiers in Plant Science, 2018
Protein disulfide isomerase (PDI) catalyzes the conversion of thiol-disulfide and plays an important role in various physiological events in animals. A PDI (OaPDI) from a tropical plant was detailed studied and it was found to be involved in response of ...
Zhengrong Zhang   +5 more
doaj   +2 more sources

Disturbed flow regulates protein disulfide isomerase A1 expression via microRNA-204 [PDF]

open access: yesFrontiers in Physiology
Redox processes can modulate vascular pathophysiology. The endoplasmic reticulum redox chaperone protein disulfide isomerase A1 (PDIA1) is overexpressed during vascular proliferative diseases, regulating thrombus formation, endoplasmic reticulum stress ...
Leonardo Y. Tanaka   +7 more
doaj   +2 more sources

A conserved protein disulfide isomerase enhances plant resistance against herbivores.

open access: yesPlant Physiology, 2022
Herbivore-associated molecular patterns (HAMPs) enable plants to recognize herbivores and may help plants adjust their defense responses. Here, we report on herbivore-induced changes in a protein disulfide isomerase (PDI) widely distributed across ...
Jia-Rong Cui   +9 more
semanticscholar   +1 more source

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