Results 51 to 60 of about 83,408 (297)

Influence of the Season and Region Factor on Phosphoproteome of Stallion Epididymal Sperm

Animals, 2021
Epididymal maturation can be defined as a scope of changes occurring during epididymal transit that prepare spermatozoa to undergo capacitation. One of the most common post-translational modifications involved in the sperm maturation process and their ...
Katarzyna Dyrda, Aleksandra Orzołek, Joanna Ner-Kluza, Paweł Wysocki   +3 more
doaj   +1 more source

Platelet Protein Disulfide Isomerase Promotes Glycoprotein Ib&agr;–Mediated Platelet-Neutrophil Interactions Under Thromboinflammatory Conditions

Circulation, 2019
Background: Platelet-neutrophil interactions contribute to vascular occlusion and tissue damage in thromboinflammatory disease. Platelet glycoprotein Ib&agr; (GPIb&agr;), a key receptor for the cell-cell interaction, is believed to be constitutively ...
Jing Li, Kyungho Kim, Si-Yeon Jeong, J. Chiu, Bei Xiong, P. Petukhov, Xiangrong Dai, Xiaoyi Li, R. Andrews, Xiaoping Du, P. Hogg, Jaehyung Cho   +11 more
semanticscholar   +1 more source

N-glycosylation of the protein disulfide isomerase Pdi1 ensures full Ustilago maydis virulence

PLoS Pathogens, 2019
Fungal pathogenesis depends on accurate secretion and location of virulence factors which drive host colonization. Protein glycosylation is a common posttranslational modification of cell wall components and other secreted factors, typically required for
Miriam Marín-Menguiano, Ismael Moreno-Sánchez, R. R. Barrales, Alfonso Fernández-Álvarez, J. Ibeas   +4 more
semanticscholar   +1 more source

Folding of small disulfide-rich proteins : clarifying the puzzle [PDF]

, 2006
Premi a l'excel·lència investigadora. Àmbit de les Ciències Experimentals. 2008The process by which small proteins fold to their native conformations has been intensively studied over the last few decades.
Apuy, Arolas, Arolas, Arolas, Arolas, Baneyx, Bardwell, Cemazar, Cemazar, Chang, Chang, Chang, Chang, Chang, Chang, Chang, Chang, Chang, Chang, Chang, Chatrenet, Creighton, Creighton, Creighton, Creighton, Creighton, Daggett, Daly, Darby, Dobson, Ellgaard, Francesc X. Aviles, Fuller, Gehrmann, Goldberg, Goldenberg, Heitz, Hogg, Houry, Joan L. Arolas, Jui-Yoa Chang, Klein-Seetharaman, Kortemme, Kuhlman, Laity, Li, Lu, Matagne, Narayan, Narayan, Narayan, Narayan, Onuchic, Permyakov, Ross, Ruoppolo, Ruoppolo, Salamanca, Salvador Ventura, Scheraga, Shimotakahara, Shin, van den Berg, van den Berg, van Mierlo, van Mierlo, Venhudova, Wedemeyer, Weissman, Welker, Welker, Wu, Yang, Zavodszky   +73 more
core   +2 more sources

Metal‐Responsive Up‐Regulation of Bifunctional Disulfides for Suppressing Protein Misfolding and Promoting Oxidative Folding

Angewandte Chemie, EarlyView.
A stress‐responsive folding promotor was developed by conjugating metal‐binding ligands and a redox‐active disulfide. The oxidative strength of the bifunctional disulfide was enhanced by metal coordination, inhibiting protein misfolding and up‐regulating the oxidative folding capacity under metal stress.
Keita Mori, Tsubura Kuramochi, Motonori Matsusaki, Yuki Hashiguchi, Masaki Okumura, Tomohide Saio, Yoshiaki Furukawa, Kenta Arai, Takahiro Muraoka   +8 more
wiley   +2 more sources

Conjugate of Thiol and Guanidyl Units with Oligoethylene Glycol Linkage for Manipulation of Oxidative Protein Folding

Molecules, 2021
Oxidative protein folding is a biological process to obtain a native conformation of a protein through disulfide-bond formation between cysteine residues.
Shunsuke Okada, Motonori Matsusaki, Masaki Okumura, Takahiro Muraoka   +3 more
doaj   +1 more source

Activation of the Unfolded Protein Response via Inhibition of Protein Disulfide Isomerase Decreases the Capacity for DNA Repair to Sensitize Glioblastoma to Radiotherapy.

Cancer Research, 2019
Patients with glioblastoma multiforme (GBM) survive on average 12 to 14 months after diagnosis despite surgical resection followed by radiotheraphy and temozolomide therapy.
Yajing Liu, W. Ji, Andrea G Shergalis, Jiaqi Xu, Amy M. Delaney, A. Calcaterra, Anupama Pal, M. Ljungman, N. Neamati, A. Rehemtulla   +9 more
semanticscholar   +1 more source

The role and mechanism of TXNDC5 in diseases

European Journal of Medical Research, 2022
Thioredoxin domain-containing protein 5 (TXNDC5) is a member of the protein disulfide isomerase (PDI) family. It can promote the formation and rearrangement of disulfide bonds, ensuring proper protein folding. TXNDC5 has three Trx-like domains, which can
Xueling Wang, Haoran Li, Xiaotian Chang
doaj   +1 more source

The transmembrane protein disulfide isomerase TMX1 negatively regulates platelet responses.

Blood, 2019
Secreted platelet protein disulfide isomerases, PDI, ERp57, ERp5, and ERp72, have important roles as positive regulators of platelet function and thrombosis.
Zhenzhen Zhao, Yi Wu, Junsong Zhou, Fengwu Chen, Aizhen Yang, D. Essex   +5 more
semanticscholar   +1 more source

Influence of ellagitannins extracted by pomegranate fruit on disulfide isomerase PDIA3 activity [PDF]

, 2019
Pomegranate fruit is a functional food of high interest for human health due to its wide range of phytochemicals with antioxidant properties are implicated in the prevention of inflammation and cancer. Ellagitannins, such as punicalagin and ellagic acid,
Altieri, Fabio, Cairone, Francesco, Carradori, Simone, Cesa, Stefania, Chichiarelli, Silvia, Giamogante, Flavia, Locatelli, Marcello   +6 more
core   +1 more source