Results 121 to 130 of about 43,163 (273)

Manipulation of the Unfolded Protein Response by Intracellular Bacterial Pathogens: Mechanisms of ER Hijacking and Therapeutic Implications

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
This review illustrates how intracellular bacterial pathogens—such as Brucella, Mycobacterium tuberculosis, and Legionella—secrete effector proteins that specifically target the IRE1α, PERK, and ATF6 branches of the unfolded protein response (UPR) to hijack ER stress signaling.
Enhui Dai, Dongjie Sun, Yanxiao Zhao, Mengtao Zhang, Yifan Wu, Jiabo Ding   +5 more
wiley   +1 more source

Extracellular PDI in thrombosis and vascular injury

Thrombosis Journal
Protein disulfide isomerase (PDI) catalyzes the reduction, oxidation, and isomerization of disulfide bonds. Although initially discovered as an endoplasmic reticulum (ER)-residing protein, PDI has been demonstrated to play critical roles on cell surfaces
Jinyu Wang, Philip J. Hogg, Xulin Xu, Chao Fang   +3 more
doaj   +1 more source

Methods of measuring Protein Disulfide Isomerase activity: a critical overview

Frontiers in Chemistry, 2014
Protein disulfide isomerase is an essential redox chaperone from the endoplasmic reticulum (ER) and is responsible for correct disulfide bond formation in nascent proteins.
Monica Massako Watanabe, Francisco Rafael Martins Laurindo, Denise C Fernandes   +2 more
doaj   +1 more source

Interactions between cell surface protein disulphide isomerase and S-nitrosoglutathione during nitric oxide delivery [PDF]

, 2007
In this study, we investigated the role of protein disulphide isomerase (PDI) in rapid metabolism of S-nitrosoglutathione (GSNO) and S-nitrosoalbumin (albSNO) and in NO delivery from these compounds into cells.
Askew, Burgess, C.M. Shah, Chen, Cooper, Crane, Crane, de Belder, Essex, Essex, Freedman, Gordge, Gordge, H.S. Chowdrey, Hogg, Hogg, Hogg, I.C. Locke, Jordan, Lahav, Lipton, Liu, Liu, M.P. Gordge, Ogura, O’Neill, Park, Park, Pfeiffer, Ramachandran, Richardson, Root, S.E. Bell, Shah, Simon, Sogo, Stamler, Walsh, Yan, Zai, Zeng, Zhang, Zhang   +42 more
core   +1 more source

Isoquercetin and Zafirlukast Cooperatively Suppress Tumor Growth and Thromboinflammatory Signaling in a Xenograft Model of Ovarian Cancer

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Treatment using either the thiol isomerase inhibitor isoquercetin or zafirlukast lowers tissue factor levels, decreases VEGF, inhibits PD‐L1, and TMEM176B in a xenograft model of ovarian cancer. A combination of the two agents, at threefold lower concentrations than either drug, significantly enhanced the inhibition further, suggesting a dual action of
Justine A. Keovilay, Jason W. Hoskins, Jean‐Pierre Kinet, Thomas C. Lines, Daniel R. Kennedy   +4 more
wiley   +1 more source

Ethanol Induced Disordering of Pancreatic Acinar Cell Endoplasmic Reticulum: An ER Stress/Defective Unfolded Protein Response Model. [PDF]

, 2018
Background & aimsHeavy alcohol drinking is associated with pancreatitis, whereas moderate intake lowers the risk. Mice fed ethanol long term show no pancreas damage unless adaptive/protective responses mediating proteostasis are disrupted. Pancreatic
Abrol, Ravinder, Capri, Joseph, Cohn, Whitaker, Faull, Kym F, Freeman, Michael R, Lugea, Aurelia, Pandol, Stephen J, Piplani, Honit, Sakkiah, Sugunadevi, Su, Hsin-Yuan, Waldron, Richard T, Whitelegge, Julian P, Yang, Wei, Zhou, Bo   +13 more
core   +3 more sources

Molecular Bases of Cyclic and Specific Disulfide Interchange between Human ERO1α Protein and Protein-disulfide Isomerase (PDI) [PDF]

, 2011
Shoji Masui, Stefano Vavassori, Claudio Fagioli, Roberto Sitia, Kenji Inaba   +4 more
openalex   +1 more source

Phylogenetic Relationship of Bombyx mori Protein Disulfide Isomerase

Zeitschrift für Naturforschung C, 2002
A cDNA that encodes protein disulfide isomerase was isolated from Bombyx mori (bPDI), in which an open reading frame of 494 amino acids contained two PDI-typical thioredoxin active sites of WCGHCK and an ER retention signal of the KDEL motif at its C-terminal. The bPDI protein shared less than 55% of the amino acid sequence homology with other reported
Tae Won, Goo, Eun Young, Yun, Jae-Sam, Hwang, Seok-Woo, Kang, Kwan-Hee, You, O Yu, Kwon   +5 more
openaire   +2 more sources

Identification and Functional Analysis of a Protein Disulfide Isomerase (AtPDI1) in Arabidopsis thaliana

Frontiers in Plant Science, 2018
Protein disulfide isomerase (PDI) catalyzes the conversion of thiol-disulfide and plays an important role in various physiological events in animals. A PDI (OaPDI) from a tropical plant was detailed studied and it was found to be involved in response of ...
Zhengrong Zhang, Xin Liu, Rong Li, Li Yuan, Yaqing Dai, Xiaoyun Wang   +5 more
doaj   +1 more source

Analysis of splice variants of the human protein disulfide isomerase (P4HB) gene [PDF]

, 2020
Daniela Kajihara, Chung-Chau Hon, Aimi Naim Abdullah, João Wosniak, Ana Iochabel Soares Moretti, Joice de Faria Poloni, Diego Bonatto, Kosuke Hashimoto, Piero Carninci, Francisco Rafael Martins Laurindo   +9 more
openalex   +1 more source