Results 131 to 140 of about 83,411 (273)

The C-terminal CGHC motif of protein disulfide isomerase supports thrombosis.

Journal of Clinical Investigation, 2015
Protein disulfide isomerase (PDI) has two distinct CGHC redox-active sites; however, the contribution of these sites during different physiologic reactions, including thrombosis, is unknown.
Junsong Zhou, Yi Wu, Lu Wang, L. Rauova, V. Hayes, M. Poncz, D. Essex   +6 more
semanticscholar   +1 more source

The Associations between Immunological Reactivity to the Haptenation of Unconjugated Bisphenol A to Albumin and Protein Disulfide Isomerase with Alpha-Synuclein Antibodies

Toxics, 2019
Patients with Parkinson’s disease (PD) have increased susceptibility to bisphenol A (BPA) exposure since they have an impaired biotransformation capacity to metabolize BPA.
Datis Kharrazian, Martha Herbert, Aristo Vojdani   +2 more
doaj   +1 more source

Quercetin-3-rutinoside Inhibits Protein Disulfide Isomerase by Binding to Its b′x Domain*

Journal of Biological Chemistry, 2015
Background: Quercetin-3-rutinoside is an inhibitor of protein disulfide isomerase, a potential target for antithrombotic therapy. Results: Quercetin-3-rutinoside induces a compact conformation in PDI and binds to PDI with an IC50 of about 10 μm ...
Lin Lin, Srila Gopal, Anish Sharda, F. Passam, S. Bowley, Jack D. Stopa, Guangpu Xue, C. Yuan, B. Furie, R. Flaumenhaft, Mingdong Huang, B. Furie   +11 more
semanticscholar   +1 more source

Review

, 2020
The chalcogen elements oxygen, sulfur, and selenium are essential constituents of side chain functions of natural amino acids. Conversely, no structural and biological function has been discovered so far for the heavier and more metallic tellurium ...
Moroder, L., Musiol, H.
core   +1 more source

Quercetin-3-Rutinoside Blocks the Disassembly of Cholera Toxin by Protein Disulfide Isomerase

Toxins, 2019
Protein disulfide isomerase (PDI) is mainly located in the endoplasmic reticulum (ER) but is also secreted into the bloodstream where its oxidoreductase activity is involved with thrombus formation.
Jessica Guyette, Patrick Cherubin, Albert Serrano, Michael Taylor, Faisal Abedin, Morgan O’Donnell, Helen Burress, Suren A. Tatulian, Ken Teter   +8 more
doaj   +1 more source

The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein*

Journal of Biological Chemistry, 2015
Background: ERp57 is a disulfide isomerase up-regulated in prion related-disorders, but its impact on PrP biology is unknown. Results: ERp57 gain- and loss-of-function can increase or reduce, respectively, PrP levels in neurons, both in cell culture and ...
Mauricio Torres, Danilo B. Medinas, J. M. Matamala, Ute Woehlbier, V. Cornejo, T. Soldà, Catherine Andreu, Pablo Rozas, S. Matus, Natalia Muñoz, C. Vergara, L. Cartier, C. Soto, M. Molinari, C. Hetz   +14 more
semanticscholar   +1 more source

Enolase 1 (ENO1) and protein disulfide-isomerase associated 3 (PDIA3) regulate Wnt/β-catenin-driven trans-differentiation of murine alveolar epithelial cells

Disease Models & Mechanisms, 2015
The alveolar epithelium represents a major site of tissue destruction during lung injury. It consists of alveolar epithelial type I (ATI) and type II (ATII) cells.
K. Mutze, S. Vierkotten, J. Milošević, O. Eickelberg, M. Königshoff   +4 more
semanticscholar   +1 more source

Cloning, expression, purification and characterization of Leishmania tropica PDI-2 protein

Open Life Sciences, 2016
In Leishmania species, protein disulfide isomerase (PDI) is an essential enzyme that catalyzes thiol-disulfide interchange. The present work describes the isolation, cloning, sequencing and expression of the pdI-2 gene.
Ali Dina, Abbady Abdul-Qader, Kweider Mahmoud, Soukkarieh Chadi   +3 more
doaj   +1 more source

Protein disulfide isomerase may facilitate the efflux of nitrite derived S-nitrosothiols from red blood cells

Redox Biology, 2013
Protein disulfide isomerase (PDI) is an abundant protein primarily found in the endoplasmic reticulum and also secreted into the blood by a variety of vascular cells.
Vasantha Madhuri Kallakunta, Anny Slama-Schwok, Bulent Mutus   +2 more
doaj   +1 more source

Inhibition of a reductive function of the plasma membrane by bacitracin and antibodies against protein disulfide-isomerase. [PDF]

, 1993
Richard Mandel, Hugues J.‐P. Ryser, F Ghani, Meng Wu, Derek Peak   +4 more
openalex   +1 more source